Area under curve

Dose range that is effective

Primary pharmacokinetic paramaters

Clearance
Volume of distribution

Clearance

volume of lood completely cleared of drug per unit time

Volume of distribution

volume and extent of distribution

volume of distribution is measured as

bigger the number the greater the distribution

Change in clearance does not impact

volume

half life

time it takes the drug concentration to be reduced by half

secondary parameters are

impacted by primary parameters

bioavailability

measured as a fraction or percentage of drug that reaches systemic circulation

the only route of drug administration that has a bioavailability of 100%

Intravenous

What is CL

clearance

What is Vd

Volume of distribution

What is t1/2

half life

What is F

Bioavailability

What is Cp

concentration- total drug

What is Cu

Unbound drug Concentration

Absorption does not equal

Accumulation

What is Absorption

Your body doing something that moves the drug from where you gave it, to the blood stream. Consider oral tablets that need to go to the brain.

What is Accumulation

Adding drug to the blood stream (IV)