front 1 Area under curve | back 1 Dose range that is effective |
front 2 Primary pharmacokinetic paramaters | back 2 Clearance |
front 3 Clearance | back 3 volume of lood completely cleared of drug per unit time |
front 4 Volume of distribution | back 4 volume and extent of distribution |
front 5 volume of distribution is measured as | back 5 bigger the number the greater the distribution |
front 6 Change in clearance does not impact | back 6 volume |
front 7 half life | back 7 time it takes the drug concentration to be reduced by half |
front 8 secondary parameters are | back 8 impacted by primary parameters |
front 9 bioavailability | back 9 measured as a fraction or percentage of drug that reaches systemic circulation |
front 10 the only route of drug administration that has a bioavailability of 100% | back 10 Intravenous |
front 11 What is CL | back 11 clearance |
front 12 What is Vd | back 12 Volume of distribution |
front 13 What is t1/2 | back 13 half life |
front 14 What is F | back 14 Bioavailability |
front 15 What is Cp | back 15 concentration- total drug |
front 16 What is Cu | back 16 Unbound drug Concentration |
front 17 Absorption does not equal | back 17 Accumulation |
front 18 What is Absorption | back 18 Your body doing something that moves the drug from where you gave it, to the blood stream. Consider oral tablets that need to go to the brain. |
front 19 What is Accumulation | back 19 Adding drug to the blood stream (IV) |