Area under curve
Dose range that is effective
Primary pharmacokinetic paramaters
Clearance
Volume of distribution
Clearance
volume of lood completely cleared of drug per unit time
Volume of distribution
volume and extent of distribution
volume of distribution is measured as
bigger the number the greater the distribution
Change in clearance does not impact
volume
half life
time it takes the drug concentration to be reduced by half
secondary parameters are
impacted by primary parameters
bioavailability
measured as a fraction or percentage of drug that reaches systemic circulation
the only route of drug administration that has a bioavailability of 100%
Intravenous
What is CL
clearance
What is Vd
Volume of distribution
What is t1/2
half life
What is F
Bioavailability
What is Cp
concentration- total drug
What is Cu
Unbound drug Concentration
Absorption does not equal
Accumulation
What is Absorption
Your body doing something that moves the drug from where you gave it, to the blood stream. Consider oral tablets that need to go to the brain.
What is Accumulation
Adding drug to the blood stream (IV)