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micro test 2 lecture 6

front 1 10/31 lecture recording	back 1 mycobacteria and TB research the who's "end TB" campaign wrap up TB module
front 2 LTBI and "active TB" a spectrum of pathology and clinical symptoms	back 2 latenty infected with TB, normally have a 10% chance over your lifetime that you will go from being latent to"active" unlucky 10% (lifetime risk) 90% chance of never suffering from your disease if individual HIV+, immune system compromised these individuals have 10% ANNUAL risk of active TB * goes from 10% LIFETIME risk in normal individuals, to 10% YEARLY risk in HIV+ individual individuals KNOW ALL OF THIS!!! much higher risk of active TB if HIV+ SIV - viruses that infected different monkey species diff monkey species react differently in some, is lethal in some species, are fine (latently/chronically infected) (kinda like how AIDS affected diff monkey species) why do some species react fine but some have lethal reactions? - is something that is trying to be figured out** TB originated in africa thought for long time it originated in europe 50-60k years ago, humans only lived in africa. TB originated there bc thats where ppl lived at the time as modern humans migrated out of africa, brought TB with them research shows that these pops had coevolution with the TB they carried if u are infected with TB that from same place ur ancestors are from, u are LESS likely to develop active TB than if infected with a TB that coevolved with a diff group of humans other than ur ancestors (then have higher chance of dev active TB0
front 3 data collected of impact of TB on the world - WHO	back 3 WHO publications 1.6 million TB deaths 2017 - special relationship btw TB and HIV TB is leading killer of ppl with HIV
front 4 mycobacteria and TB research in USA:	back 4 in US, the organization in charge of research on disease + medical treatment of TB headed by NIH special page for TB we need to read sub branch: NIAID (national institute of allergies and infectious disease) for basic + medical research fir epiodemiological research - by CDC preventing + containing TB outbreaks for info about location, incidence, etc. in the US non government organizations (NGOs) Bill/Melinda gates foundation...

front 5 WHO's "end TB" campaign	back 5 World TB day - march 24th has to do with when robert caulk discovered cause of TB made announcement on march 24th
front 6 WHO mission statement	back 6 seeks to publish and disseminate scientifically rigorous public health information of international significance that enables policy makers, researchers and practitioners to be more effective; it aims to improve health, particularly among disadvantaged populations policy makers end TB strategy TB report TB country profiles researchers depends on the type of research practitioners guidelines on the management of latent TB treatment of TB guidelines
front 7 strategy: the big plan	back 7 end TB strategy 3 pillars
front 8 reports	back 8 how well is big plan working? reading 1 - brochure, END TB strategy brochure country by country reports

front 9 reports - individual country profiles	back 9 ex: angola 2018 107k cases of TB
front 10 international efforts	back 10 tactical "field guides" guidelines on the management of latent TB infection, active TB, etc.