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22 notecards = 6 pages (4 cards per page)

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Pharmacology Macrolides and drugs not in a class

front 1

What is the prototype for Macrolides?

back 1

erythromycin

front 2

What do macrolides do?

back 2

they bind to bacterial ribosomes, stopping protein synthesis

front 3

What do we use macrolides for?

back 3

as a penicillin alternative and to prevent conjunctivitis in newborns (as an eye ointment)

front 4

What are macrolides spectrum of activity?

back 4

broad

front 5

What are some nursing considerations when it comes to macrolides?

back 5

don't give to patients with hepatic failure, can cause mood changes, and GI effects

front 6

What do all macrolides have?

back 6

no need for renal adjustments

front 7

What macrolides can potentially cause C.diff?

back 7

erythromicin and clindamycin

front 8

Why would we use clindamycin?

back 8

to treat for anaerobic bactera (specifically for Bacteroides fragilus)

front 9

Clindamycin has a BBW for what?

back 9

C. diff

front 10

What does metronidazole do?

back 10

disrupts DNA

front 11

What do we use metronidazole for?

back 11

to treat C. diff.

front 12

What is metronidazole's spectrum of activity?

back 12

mostly for anaerobic bacteria

front 13

What is a nursing consideration for metronidazole?

back 13

DO NOT drink alcohol during treatment and for 3 days after

front 14

What does vancomycin do?

back 14

inhibits BW synthesis

front 15

What do we use vancomycin for?

back 15

Treating MRSA/MSSA, and C.diff (oral only)

front 16

What is vancomycin's spectrum of activity?

back 16

ONLY gram positive (the big gram positive drug)

front 17

What are some nursing considerations for vancomycin?

back 17

A slow IV over 1-2 hours could cause "red man syndrome" and needs renal dose adjustments (monitor PEAKS and TROUGHS (lowest serum drug level))

front 18

What does linezolid do?

back 18

inhibits bacterial protein synthesis

front 19

What do we use linezolid for?

back 19

treating VRE (vancomycin resistant enterococcus) and MRSA

front 20

What is linezolid's spectrum of activity?

back 20

only Gram positive (L)

front 21

What are some nursing considerations for linezolid?

back 21

possible serotonin syndrome if used with serotonergic drugs, and myleosuppression (anemia).

front 22

Linezolid has a BBW. What is it?

back 22

interaction with serotonergic drugs (can lead to Serotonin syndrome)