What your body does to a drug

Pharmacokinetics

What the drug does to your body

Pharmacodynamics

What does ADME stand for?

Administration

Distribution

Metabolism

Excretion

What does administration of a drug deal with?

Small Intestine

What does distribution deal with?

Blood flow

What part of the body does metabolism deal with?

Liver

What part of the body does excretion deal with?

Kidneys

Tylenol is known as the drug's

trade name

the highest level of a drug

peak

the lowest level of a drug

trough

what is known as the "wiggle room or sweet spot" of a drug

therapeutic index

recirculation of a drug within the body is known as

enterohepatic circulation

what does enterohepatic circulation do to a drug?

prolongs the effect of the medication

What medication are considered first pass effect?

Oral medication

What is medication left in the body called?

Bioavailability

What meds bypass first effect ? Give 3 examples

IV, IM, and Sublingual

What binds to the receptor?

Agonist

What blocks the receptor?

Antangonist

binding to the receptor is called?

affinity

activates the receptor (snaps fingers)

efficacy

strength of med is called

potency

What medication classes do you NOT give to pregnant woman?

Category X and Category D

How many categories of medication are there?

5

Category I?

Street drugs (weed, LSD)

Category II?

Hospital drugs (morphine, Dilaudid)

Category III?

Codeine, Ketamine

Category IV?

Benzos

Category V?

Purple Drank (cough syrup)

When is a second witness needed? For which category of drug?

Category V

What three herbal supplements do you need to look out for bleeding ?

Ginger

Ginkgo

Garlic

Which herbal supplement contraindicates taking with sedatives?

Valerian Root

The "special" problem listed on a medication label

Black Box Warning

Broad spectrum antibiotics

Empiric

Acute therapy

nitro for HA

Maintenance

BP meds

palliative therapy

end of life comfort

supplemental therapy

fluid and electrolyte balance

supportive therapy

preventative ex: dehydration

example of prophylactic

antibiotics before surgery

special anatomic barriers that prevent many chemicals and medications from entering

Blood-brain & Fetal-placental barrier

what drug counteracts benzodiazepines?

Flumazenil

what drug counteracts Tylenol?

Acetylcysteine

what drug counteracts beta blockers?

Glucagon

what drug counteracts carbon monoxide?

Oxygen

higher dose of drugs often given once or twice to prime the blood stream of sufficient level of drug?

loading dose