What your body does to a drug
Pharmacokinetics
What the drug does to your body
Pharmacodynamics
What does ADME stand for?
Administration
Distribution
Metabolism
Excretion
What does administration of a drug deal with?
Small Intestine
What does distribution deal with?
Blood flow
What part of the body does metabolism deal with?
Liver
What part of the body does excretion deal with?
Kidneys
Tylenol is known as the drug's
trade name
the highest level of a drug
peak
the lowest level of a drug
trough
what is known as the "wiggle room or sweet spot" of a drug
therapeutic index
recirculation of a drug within the body is known as
enterohepatic circulation
what does enterohepatic circulation do to a drug?
prolongs the effect of the medication
What medication are considered first pass effect?
Oral medication
What is medication left in the body called?
Bioavailability
What meds bypass first effect ? Give 3 examples
IV, IM, and Sublingual
What binds to the receptor?
Agonist
What blocks the receptor?
Antangonist
binding to the receptor is called?
affinity
activates the receptor (snaps fingers)
efficacy
strength of med is called
potency
What medication classes do you NOT give to pregnant woman?
Category X and Category D
How many categories of medication are there?
5
Category I?
Street drugs (weed, LSD)
Category II?
Hospital drugs (morphine, Dilaudid)
Category III?
Codeine, Ketamine
Category IV?
Benzos
Category V?
Purple Drank (cough syrup)
When is a second witness needed? For which category of drug?
Category V
What three herbal supplements do you need to look out for bleeding ?
Ginger
Ginkgo
Garlic
Which herbal supplement contraindicates taking with sedatives?
Valerian Root
The "special" problem listed on a medication label
Black Box Warning
Broad spectrum antibiotics
Empiric
Acute therapy
nitro for HA
Maintenance
BP meds
palliative therapy
end of life comfort
supplemental therapy
fluid and electrolyte balance
supportive therapy
preventative ex: dehydration
example of prophylactic
antibiotics before surgery
special anatomic barriers that prevent many chemicals and medications from entering
Blood-brain & Fetal-placental barrier
what drug counteracts benzodiazepines?
Flumazenil
what drug counteracts Tylenol?
Acetylcysteine
what drug counteracts beta blockers?
Glucagon
what drug counteracts carbon monoxide?
Oxygen
higher dose of drugs often given once or twice to prime the blood stream of sufficient level of drug?
loading dose