Dextrose (D50, D25, D10)

Duration of Action

• Onset:<1min
• Peak Effect: Variable
• Duration: Variable

Diazepam (Valium)

Duration of Action

• Onset: 1 - 5mins
• Peak Effect: within mins
• Duration: 20 - 50mins

Diphenhydramine hydrochloride (Benadryl)

Duration of Action

• Onset: 15 - 30mins
• Peak Effect: 1hr
• Duration: 3 - 12hrs

Epinephrine (1:1000, 1:10,000)

Duration of Action

• Onset: Immediate
• Peak Effect: Minutes
• Duration: Several minutes

Fentanyl citrate (Sublimaze)

Duration of Action

• Onset: The onset of action is almost immediate when the drug is given intravenously; however, the maximal analgesic and respiratory depressant effect may not be noted for several minutes.
• Peak Effect: The peak respiratory depressant effect of a single intravenous dose of is noted as 5 to 15 minutes following injection.
• Duration: The usual duration of action of the analgesic effect is 30 to 60 minutes after a single intravenous dose of up to 100 mcg.

Glucagon

Duration of Action

• Onset: 1min
• Peak Effect: 30mins
• Duration: Variable (generally 9 - 17mins)

Hydrocortisone sodium succinate (Cortef, Solu-Cortef)

Duration of Action

• Onset: Mins - hrs (depending on indication).
• Peak Effect: 8 - 12hrs

Hydroxocobalamin (Vitamin B 12)
*cyano-kit

Unknown

Ketamine (Ketalar)

Duration of Action

• Onset: 10mins
• Peak Effect: 1 - 2hrs
• Duration: 2 - 6hrs

Lorazepam (Ativan)

Duration of Action

• Onset: 1 - 5mins
• Peak Effect: Variable
• Duration: 6 - 8hrs

Methylprednisolone sodium succinate (Solu-Medrol)

Duration of Action

• Onset: Mins - hrs (depending on indication).
• Peak Effect: 8 - 12hrs

Midazolam (Versed)

Duration of Action

• Onset: 1 - 3mins (IV) & dose dependent
• Peak Effect: Variable
• Duration: 2 - 6hrs & dose dependent

Naloxone (Narcan)

Duration of Action

• Onset: within 2mins
• Peak Effect: Variable
• Duration: 30 - 60 minutes

Ondansetron (Zofran)

Duration of Action

• Onset: Approximately 30 minutes
• Half-life:
  Children <5 years: 2-3 hours
  Adults : 3-6 hours

Pralidoxime chloride (2-PAM, Protopam)

Duration of Action

• Onset: Minutes
• Peak Effect: Variable
• Duration: Variable

Tranexamic acid (TXA)

Duration of Action

• Onset: Unknown
• Peak Effect: Unknown
• Duration: 7-8 hours