front 1 What is an antibody? | back 1 (immunoglobulin) Proteinaceous antigen-binding molecule secreted by plasma cells. |
front 2 What is an antigen? Distinguish between epitope and antigen | back 2 antigen: foreign material epitope: the specific regions on an antigen recognized by specific antigen receptors, that is, the part of the antigen that fits into the antigen binding site of the antigen receptor. |
front 3 What is the process that stimulates B cell proliferation and differentiation to plasma cells? (clonal selection mechanism) | back 3
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front 4 What are the different mechanisms that antibodies contribute to immunity? | back 4 Effectors:
Receptors:
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front 5 What are cytokines? | back 5 Proteins secreted by many types of cells that regulate adaptive immune responses |
front 6 explain the role of B cells, T helper cells (TH 1 and TH 2) and cytotoxic T cells. | back 6
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front 7 Explain the difference between activity immunity and passive immunity. | back 7 Active immunity occurs when the body mounts an immune response to an antigen - effector cells and memory cells are generated. Passive immunity occurs when a person is given preformed antibodies - no lymphocyte activation, no effector cells, no memory cells. |
front 8 What is the role of natural killer cells? | back 8
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front 9 How are anti-venoms made? | back 9 is created by milking venom from a relevant snake, spider, insect, or fish. The venom is then diluted and injected into a horse, sheep, rabbit, or goat. |
front 10 Protein deficiency still occurs in many populations throughout the world. Individuals with protein deficiency can be more susceptible to diseases. Explain | back 10
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front 11 What is the role of activated cytotoxic T cell? | back 11 recognize and destroy non-self cells by puncturing them, causing them to lyse These cells secrete cytotoxin which triggers destruction of the pathogen's DNA or perforin which is a protein that creates holes in the pathogens plasma membrane. The holes cause the pathogen to lyse (rupture). |
front 12 What is the role of helper T cells in acquired immunity? | back 12 These cells secrete interleukin 2 (I-2) which stimulates cell division of T cells and B cells. In other words, these cells recruit even more cells to help fight the pathogen. |
front 13 Immunologists: | back 13 scientists who study the cells and chemicals involved in specific immunity |
front 14 Cell-mediated immune response | back 14 Immune response used by T cells to fight intracellular pathogens and abnormal body cells. |
front 15 Humoral immune response | back 15 The immune response centered around B lymphocytes and antibodies. |
front 16 Acquired immunity: | back 16 The body’s ability to recognize and defend itself against distinct invaders and their products Is a “smart” system whose “memory’ allows it to respond rapidly to a second encounter with a pathogen Is acquired over time Antigens trigger specific immune responses• Various cells, tissues, and organs are part of specific immunity Includes B and T lymphocytes |
front 17 Adaptive immunity: | back 17 Resistance against pathogens that acts more effectively upon subsequent infections with the same pathogen. |
front 18 Opsonization | back 18 The coating of pathogens by proteins called opsonins, making them more vulnerable to phagocytes |
front 19 T lymphocytes | back 19 (T cell) Lymphocyte that matures in the thymus and acts primarily against endogenous antigens in cell-mediated immune responses. |
front 20 B Lymphocytes | back 20 (B cell) Lymphocyte that arises and matures in the red bone marrow in adults and is found primarily in the spleen, lymph nodes, red bone marrow, and Peyer's patches of the intestines and that secretes antibodies. |
front 21 Lymphocyte | back 21 Type of small agranulocyte, which originates in the red bone marrow and has nuclei that nearly fill the cell. |
front 22 Antigen | back 22 Molecule that triggers a specific immune response. foreign material |
front 23 Lymphatic System | back 23 is a network of lymph capillaries and larger vessels that empty into the circulatory system |
front 24 Lymphatic Vessels | back 24 tubes that conduct lymph |
front 25 Lymphoid cells | back 25 Develop from stem cells in the red bone marrow Includes lymphocytes, the smallest of the leukocytes B lymphocytes(B cells) T lymphocytes(Tcells) |
front 26 Lymph | back 26 Fluid found in lymphatic vessels that is similar in composition to blood serum and intercellular fluid. |
front 27 Lymph Nodes | back 27 Organs that monitor the composition of lymph
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front 28 Spleen | back 28 Similar function as lymph nodes, except that it filters the blood |
front 29 Tonsils | back 29 Patches of tissue with large numbers of lymphocytes |
front 30 Mucosa-associated lymphoid disease [MALT]: | back 30 made up of peyers patches, the appendix, and the tonsils. It protects passages that are open to the exterior from the never-ending onslaughts of foreign matter entering them |
front 31 Antibodies: | back 31 (immunoglobulin) Proteinaceous antigen-binding molecule secreted by plasma cells. |
front 32 B Cell receptor [BCR]: | back 32 Antibody integral to the cytoplasmic membrane and expressed by B lymphocytes. |
front 33 Memory B Cells | back 33 B lymphocyte that migrates to lymphoid tissues to await a subsequent encounter with antigen previously encountered. |
front 34 Agglutination | back 34 Aggregation (clumping) caused when antibodies bind to two antigens, perhaps hindering the activity of pathogenic microorganisms and increasing the chance that they will be phagocytized. |
front 35 Neutralization | back 35 Antibody function in which the action of a toxin or attachment of a pathogen is blocked. |
front 36 Cytotoxic T cells: | back 36 (Tc cell, CD8 cell) In cell-mediated immune response, type of cell characterized by CD8 cell-surface glycoprotein; secretes perforins and granzymes that destroy infected or abnormal body cells. |
front 37 Helper T cells | back 37 (Th cell, CD4 cell) In cell-mediated immune response, a type of cell characterized by CD4 cell-surface glycoprotein; regulates the activity of B cells and cytotoxic T cells. |
front 38 CD8: | back 38 (cytotoxic T cell, Tc cell) In cell-mediated immune response, type of cell characterized by CD8 cell-surface glycoprotein; secretes perforins and granzymes that destroy infected or abnormal body cells. |
front 39 Cytokines: | back 39 Proteins secreted by many types of cells that regulate adaptive immune responses |
front 40 Interleukins [ILs]: | back 40 Immune system cytokines that signal among leukocytes |
front 41 Chemokines: | back 41 An immune system cytokine that signals leukocytes to rush to the site of inflammation or infection and activate other leukocytes. |
front 42 Autoantigens: | back 42 Antigens on the surface of normal body cells. |
front 43 Clonal Selection: | back 43 In antibody immunity, recognition and activation only of B lymphocytes with BCRs complementary to a specific antigenic determinant. |
front 44 Major Histocompatibility Complex [MHC]: | back 44 A cluster of genes, located on each copy of chromosome 6 in humans, that codes for membrane-bound glycoproteins called major histocompatibility antigens. Important in determining the compatibility of tissues in successful grafting |
front 45 MHC class 1: | back 45 Found on all cells except red blood cells |
front 46 MHC class 2 | back 46 Found on B-cells and antigen-presenting cells |
front 47 Plasma cells | back 47 B cells that are actively fighting against exogenous antigens and secreting antibodies. |
front 48 Phagolysosome: | back 48 APC internalizes the invading pathogen and enzymatically digests it into smaller antigenic fragments which are contained within a phagolysosome Phagolysosome fuses with a vesicle containing MHCII molecules |
front 49 CD4: | back 49 Distinguishing cytoplasmic membrane protein of helper T cells, which is the initial binding site of HIV. |
front 50 CD4 cell: | back 50 (helper T cell, Th cell) In cell-mediated immune response, a type of cell characterized by CD4 cell-surface glycoprotein; regulates the activity of B cells and cytotoxic T cells. |
front 51 Dendritic cells | back 51 Cells of the epidermis and mucous membranes that devour pathogens. |
front 52 Anti-venoms: | back 52 biological product used in the treatment of venomous bites or stings. Antivenom is created by milking venom from a relevant snake, spider, insect, or fish. The venom is then diluted and injected into a horse, sheep, rabbit, or goat. |
front 53 Class-switching: | back 53 The process in which a plasma cell changes the type of antibody Fc region (stem) that it synthesizes and secretes. |
front 54 Adaptive immunity: | back 54 attacks particular foreign substances and provides body's 3rd line of defense |
front 55 Fc Region: | back 55 The stem region of an antibody. |
front 56 IgA: | back 56 The antibody class most commonly associated with various body secretions, including tears and milk. IgA pairs with a secretory component to form secretory IgA. |
front 57 IgG: | back 57 The predominant antibody class found in the bloodstream and the primary defender against invading bacteria. |
front 58 IgM: | back 58 The second most common antibody class and the predominant antibody produced first during a primary humoral immune response. |
front 59 IgD: | back 59 A membrane-bound antibody molecule found in some animals as a B cell receptor. |
front 60 IgE: | back 60 Signal antibody molecule that triggers the inflammatory response, particularly in allergic reactions and infections by parasitic worms. |
front 61 Antigenic determinant: | back 61 (epitope) the three- dimensional shape of a region of an antigen that is recognized by the immune system. The part of the antigen that is recognized |
front 62 Endogenous antigen: | back 62 Antigen produced by microbes that multiply inside the cells of the body. |
front 63 Tr cell: | back 63 (regulatory T cell, suppressor T cell) Thymus-matured lymphocyte that serves to repress adaptive immune responses and prevent autoimmune diseases. |
front 64 Clonal deletion: | back 64 Process by which cells with receptors that responds to autoantigens are selectively killed via apoptosis. |
front 65 Secretory IgA: | back 65 The combination of IgA and a secretory component, found in tears, mucous membrane secretions, and breast milk, where it agglutinates and neutralizes antigens. |
front 66 Exogenous antigen: | back 66 Antigen produced by microorganisms that multiply outside the cells of the body. |
front 67 T-independent antigens: | back 67 Large molecules with repeating subunits that trigger an antibody immune response without the activation of T cells. |
front 68 Antigen-Binding site: | back 68 Site formed by the variable regions of a heavy and light chain of an antibody. |
front 69 Regulatory T-cell: | back 69 (Tr cell, suppressor T cell) Thymus- matured lymphocyte that serves to repress adaptive immune responses and prevent autoimmune diseases. |
front 70 Artificially acquired passive immunotherapy: | back 70 Treatment in which patient receives via injection preformed antibodies in antitoxins or antisera, which can destroy fast-acting and potentially fatal antigens, such as rattlesnake venom. |
front 71 Artificially acquired active immunity: | back 71 occurs when person is given a vaccine |
front 72 Naturally acquired active immunity | back 72 occurs when a person suffers through the symptoms of an infection. |
front 73 Naturally acquired passive immunity | back 73 occurs when a mother’s antibodies enter fetal circulation. |
front 74 Memory T cell: | back 74 Type of T cell that persists in lymphoid tissues for months or years awaiting subsequent contact with an antigenic determinant matching its TCR, at which point it produces cytotoxic T cells. |
front 75 Th cell: | back 75 (helper T cell, CD4 cell) In cell-mediated immune response, a type of cell characterized by CD4 cell-surface glycoprotein; regulates the activity of B cells and cytotoxic T cells. |
front 76 Apoptosis: | back 76 Programmed cell suicide. |
front 77 Granzyme: | back 77 Protein molecule in the cytoplasm of cytotoxic T cells that causes an infected cell to undergo apoptosis. |
front 78 CD95 pathway: | back 78 In cell-mediated cytotoxicity, pathway involving CD95 protein that triggers apoptosis of infected cells. |
front 79 Epitope: | back 79 (antigenic determinant) The three- dimensional shape of a region of an antigen that is recognized by the immune system. |
front 80 Interferons [IFs]: | back 80 Protein molecules that inhibit the spread of viral infections. |
front 81 Memory response: | back 81 The rapid and enhanced immune response to a subsequent encounter with a familiar antigen. |
front 82 Tc cell: | back 82 (cytotoxic T cell, CD8 cell) In cell-mediated immune response, type of cell characterized by CD8 cell-surface glycoprotein; secretes perforins and granzymes that destroy infected or abnormal body cells. |
front 83 Perforin: | back 83 Protein molecule in the cytoplasm of cytotoxic T cells, which forms channels [pores] (perforations) in an infected cell's membrane. |
front 84 Naturally acquired active immunity: | back 84 Type of immunity that occurs when the body responds to exposure to antigens by mounting specific immune responses. |
front 85 Naturally acquired passive immunity: | back 85 Type of immunity that occurs when a fetus, newborn, or child receives antibodies across the placenta or within breast milk. |
front 86 T-independent antibody immunity: | back 86 Adaptive immune response resulting in immunoglobulin production following cross-linking of BCRs on numerous B cells and lacking involvement of helper T cells. |
front 87 Opsonin: | back 87 Antimicrobial protein that enhances phagocytosis. |
front 88 Primary response: | back 88 The slow and limited immune response to a first encounter with an unfamiliar antigen. |
front 89 Secondary immune response: | back 89 Enhanced immune response following a second contact with an antigen. |
front 90 T-dependent antibody immunity: | back 90 Adaptive immune response resulting in immunoglobulin production that requires the action of a specific helper T cell (Th2). |
front 91 Antigen-presenting cell [APC]: | back 91 Dendritic cells, macrophages, and B cells, which process antigens and activate cells of the immune system. |
front 92 Antibody immune Response [humoral immune response: | back 92 The immune response centered around B lymphocytes and antibodies |
front 93 Antibody-dependent cellular cytotoxity [ADCC]: | back 93 Process whereby natural killer lymphocytes (NK cells) lyse cells covered with antibodies. |
front 94 Growth factor: | back 94 Organic chemical, such as a vitamin, required in very small amounts for metabolism. In immunology, an immune system cytokine that stimulates stem cells to divide, ensuring that the body is supplied with sufficient leukocytes of all types. |
front 95 Synapse: | back 95 In immunology, the interface between cells of the immune system that involves cell-to-cell signaling |
front 96 T-dependent antigens: | back 96 Molecules that stimulate an immune response only with the involvement of a helper T cell. |
front 97 Artificially acquired active immunity: | back 97 Type of immunity that occurs when the body receives antigens by injection, as with vaccinations, and mounts a specific immune response |
front 98 T cell receptor [TCR]: | back 98 Antigen receptor generated in the cytoplasmic membrane of T lymphocytes. |
front 99 Tumor necrosis factor [TNF]: | back 99 An immune system cytokine secreted by macrophages and T cells to kill tumor cells and to regulate immune responses and inflammation. |
front 100 T cell Pathway | back 100
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front 101 Cytotoxic T cell pathway | back 101
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front 102 antibody function | back 102 Activation of complement Stimulation of inflammation Agglutination: so they can’t spread apart and to make it easier for phagocytosis Neutralization Opsonization |