front 1 Khorana (1961) | back 1 Continued to elucidate the mRNA codons |
front 2 Nirenberg & Matthaei (1961) | back 2 Synthesized mRNA with known nucleotides to determine which amino acids are translated |
front 3 Franklin & Wilkins (1953) | back 3 x-ray diffraction, determined the structure of DNA |
front 4 Meselson & Stahl (1958) | back 4 Labeled parental DNA 15N and transferred to 14N, extract DNA after gen 1 and gen 2 to determine that replication is semi-conservative |
front 5 Cech (1981) | back 5 Self splicing introns ( sign of ribozymatic activity) |
front 6 Gilbert (1986) | back 6 RNA can both hold information and act catalytically, the ancestral biomolecule |
front 7 Ingram(1957) | back 7 Mutation the result of one amino acid change results in protein structure changing |
front 8 Yanofsky(1963) | back 8 Relative order of a mutation in a gene sequence is relative to the order of the protein sequence. |
front 9 Lederberg & Tatum (1946) | back 9 Discovered gene exchange in E. coli, that physical contact is needed and transfer is directional. |
front 10 Griffith (1928) | back 10 Rough and smooth strain of virus in mice. Non-living substance responsible for transformation. |
front 11 Avery, MacLeod, & McCarty (1944) | back 11 Eliminated different components of a HK strain where when DNA was destroyed no transformation. |
front 12 Hershey & Chase (1952) | back 12 Radioactively labeled T2 phage. Proved DNA was responsible for hereditary not proteins |
front 13 Chargaff (1949) | back 13 Nucleotides are not equally represented |
front 14 Beadle & Tatum (1940s) | back 14 Created mutant strain unable to synthesize arginine therefore connecting genes to metabolic pathways. |
front 15 Sturtevant (1911) | back 15 Use recombinant frequencies to map spatial relationship of genes on the same chromosome. |
front 16 Carothers (1913) | back 16 Demonstrated independent segregation in anaphase I using heteromorphic chromosomes in grasshoppers. |
front 17 Morgan (1910) | back 17 Isolated red and white yes is drosophila and demonstrated sex linked genes. |