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Pharmacology Aminoglycosides and Fluroquinolones

front 1

What is aminoglycoside's prototype drug?

back 1

gentamycin

front 2

How do aminoglycosides work?

back 2

they break down bacteria's ribosomes

front 3

You would normally take aminoglycosides by themselves. T/F

back 3

False. Take aminoglycosides with penicillins or vancomysin for a synergistic effect.

front 4

What is aminoglycosides spectrum of activity?

back 4

It is effective against gram negative bacteria.

front 5

Aminoglycosides have a BBW. What is it for?

back 5

ototoxicity and nephrotoxicity (make sure to check labs after peak for creatine levels (renal function). If creatine levels are elevated (renal function is getting worse), hold and notify the provider.)

front 6

What is fluroquionoles prototype drug?

back 6

ciprofloxacin

front 7

What do all fluroquinoles end in?

back 7

"-flaxin"

front 8

How do fluroquinoles work?

back 8

They interfere with the production of bacterial DNA

front 9

What would we use ciprofloxacin for?

back 9

It is considered the first line drug for Bacillus anthrasis (anthrax).

front 10

What are fluroquinoles spectrum of activity?

back 10

they are broad spectrum (F)

front 11

What route would we give ciprofloxacin in?

back 11

orally ONLY

front 12

Ciprofloxacin has a BBW. What are they?

back 12

tendonitis/tendon rupture, exacerbates weakness in myasthenia gravis.

front 13

What would we tell a patient who was just prescribed Ciprofloxacin?

back 13

DO NOT take with iron, multivitamins, calcium, dairy products, and AVOID exposure to sunlight. Take 2 hours before or 6 hours after any of these.

front 14

A patient currently taking ciprofloxacin is about to have an EKG done. What would be a possible expectation seen on their results?

back 14

QT prolongation (longer heartbeat)