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Chapter 19 Blood

front 1

Plasma is closest in composition to

A) urine.

B) isotonic saline solution.

C) sterile water.

D) CSF.

E) interstitial fluid.

back 1

E) interstitial fluid.

front 2

The percent fraction of formed elements relative to whole blood is the

A) viscosity.

B) specific gravity.

C) packed volume.

D) hematocrit.

E) differential cell count.

back 2

D) hematocrit.

front 3

Which of the following is a function of the blood?

A) transport of nutrients and wastes

B) transport of body heat

C) transport of gases

D) defense against toxins and pathogens

E) All of the answers are correct.

back 3

E) All of the answers are correct.

front 4

Which of the following statements about blood is false?

A) Blood contains buffers that control pH.

B) The normal pH of blood is 6.8 to 7.0.

C) Blood is more viscous than water.

D) Blood is about 55 percent plasma.

E) Cells in blood comprise the formed elements.

back 4

B) The normal pH of blood is 6.8 to 7.0.

front 5

Formed elements make up about what percentage of blood?

A) 55 percent

B) 30 percent

C) 60 percent

D) 45 percent

E) 20 percent

back 5

D) 45 percent

front 6

The combination of plasma and formed elements is called

A) serum.

B) lymph.

C) whole blood.

D) extracellular fluid.

E) packed blood.

back 6

C) whole blood.

front 7

Whole blood for testing in a clinical laboratory is usually collected from

A) the heart.

B) a superficial artery.

C) a superficial vein.

D) a capillary.

E) an arteriole

back 7

C) a superficial vein.

front 8

When checking the efficiency of gas exchange, it may be necessary to draw a blood sample from

A) the heart.

B) the lungs.

C) an artery.

D) a vein.

E) capillaries.

back 8

C) an artery.

front 9

Consider the following results from a blood lab test. Which value is most likely abnormal?

A) RBCs—5.2 million/µl

B) platelets—280,000/µl

C) leukocytes—8600/µl

D) hemoglobin—10.7 g/100 ml

E) hematocrit—44 percent

back 9

D) hemoglobin—10.7 g/100 ml

front 10

Each of the following is a characteristic of whole blood, except a

A) temperature of approximately 38 degrees Celsius.

B) viscosity about the same as water.

C) pH of 7.4.

D) built-in system for clotting.

E) red color from hemoglobin.

back 10

B) viscosity about the same as water.

front 11

The total volume of blood in the body of a 76-kg man is approximately ________ liters.

A) 10

B) 6 to 8

C) 5.3

D) 4.4

E) 3.8

back 11

C) 5.3

front 12

The most abundant component of plasma is

A) ions.

B) proteins.

C) water.

D) gases.

E) nutrients.

back 12

C) water.

front 13

A person who has a low blood volume is said to be

A) hypovolemic.

B) hypervolemic.

C) normovolemic.

D) isovolemic.

E) antivolemic.

back 13

A) hypovolemic.

front 14

The chief difference between plasma and interstitial fluid involves the concentration of

A) water.

B) electrolytes.

C) nitrogen wastes.

D) proteins.

E) glucose.

back 14

D) proteins.

front 15

A typical adult hematocrit is

A) 85.

B) 75.

C) 65.

D) 45.

E) 25.

back 15

D) 45.

front 16

Which of the following is not one of the formed elements of blood?

A) RBCs

B) platelets

C) antibodies

D) lymphocytes

E) basophils

back 16

C) antibodies

front 17

Plasma composes about ________ percent of whole blood and water composes ________ percent of the plasma volume.

A) 55; 92

B) 92; 7

C) 92; 55

D) 45; 55

E) 50; 50

back 17

A) 55; 92

front 18

A hematocrit provides information on

A) blood type.

B) clotting factors.

C) formed elements abundance.

D) plasma composition.

E) sedimentation rate.

back 18

C) formed elements abundance.

front 19

You are caring for an adult patient who weighs 48 kg. What would her approximate blood volume be?

A) 6.6 L

B) 6.0 L

C) 5.6 L

D) 4.8 L

E) 3.8 L

back 19

E) 3.8 L

front 20

Thyroid-binding globulin is an example of which kind of plasma protein?

A) metalloprotein

B) steroid-binding

C) hormone-binding

D) apolipoprotein

E) transport albumin

back 20

C) hormone-binding

front 21

Transferrin is an example of which kind of plasma protein?

A) metalloprotein

B) steroid-binding protein

C) hormone-binding protein

D) apolipoprotein

E) transport albumin

back 21

A) metalloprotein

front 22

Which plasma protein transports fatty acids and some hormones?

A) translipin

B) steroid-binding protein

C) hormone-binding protein

D) albumin

E) gamma globulin

back 22

D) albumin

front 23

Which organ secretes most of the plasma proteins?

A) pancreas

B) heart

C) kidney

D) brain

E) liver

back 23

E) liver

front 24

The most abundant proteins in blood plasma are

A) globulins.

B) transport proteins.

C) albumins.

D) lipoproteins.

E) fibrinogens.

back 24

C) albumins.

front 25

Plasma proteins essential in body defense are the

A) albumins.

B) fibrinogens.

C) immunoglobulins.

D) metalloproteins.

E) lipoproteins.

back 25

C) immunoglobulins.

front 26

A plasma protein essential for blood coagulation is

A) albumin alpha.

B) fibrinogen.

C) immunoglobulin

D) metalloprotein

E) lipoprotein

back 26

B) fibrinogen.

front 27

All the circulating red blood cells in an adult originate in the

A) heart.

B) thymus.

C) spleen.

D) red bone marrow.

E) lymph tissue.

back 27

D) red bone marrow.

front 28

Red blood cell production is regulated by the hormone

A) thymosin.

B) angiotensin.

C) erythropoietin.

D) M-CSF.

E) renin.

back 28

C) erythropoietin.

front 29

Which of the following statements concerning red blood cells is false?

A) Red cells are biconcave discs.

B) Red cells lack mitochondria.

C) Red cells are about 18 µm in diameter.

D) Red cells are specialized for carrying oxygen.

E) Red cells can form stacks called rouleaux.

back 29

C) Red cells are about 18 µm in diameter.

front 30

Which of these proteins functions to store or transport iron?

A) hemoglobin

B) ferritin

C) hemosiderin

D) transferrin

E) ferritin, hemosiderin, and transferrin

back 30

E) ferritin, hemosiderin, and transferrin

front 31

The disease sickle cell anemia is an example of what can happen if

A) the diet is deficient in iron.

B) there is insufficient heme in the hemoglobin.

C) a gene for adult hemoglobin is abnormal.

D) red blood cells bind too much oxygen.

E) hemolysis is prevented by a mutated gene.

back 31

C) a gene for adult hemoglobin is abnormal.

front 32

When a person who lives at sea level vacations in the Rocky Mountains, you would expect

A) a drop in atmospheric oxygen levels.

B) the release of erythropoietin.

C) a rise in hematocrit.

D) an increase in red blood cell production.

E) All of the answers are correct.

back 32

E) All of the answers are correct.

front 33

Surgical removal of the stomach could cause

A) hemophilia.

B) pernicious anemia.

C) thrombocytopenia.

D) leukocytosis.

E) jaundice.

back 33

B) pernicious anemia.

front 34

Mary is tested for the amount of hemoglobin in her blood. The test results indicate that her hemoglobin level is 16 g/dL of blood. This value indicates that

A) she is suffering from anemia.

B) she has fewer red blood cells than normal.

C) her hematocrit is probably lower than normal.

D) she may be suffering from a form of leukemia.

E) her hemoglobin level is normal.

back 34

E) her hemoglobin level is normal.

front 35

An obstruction in blood flow to the kidneys would ultimately result in

A) pernicious anemia.

B) renal anemia.

C) increased erythropoiesis.

D) decreased erythropoiesis.

E) increased sensitivity to vitamin K.

back 35

C) increased erythropoiesis.

front 36

The level of erythropoietin in the blood would rise due to all of the following, except

A) during anemia.

B) at high altitudes.

C) as a consequence of hemorrhage.

D) during periods of fasting.

E) when blood flow to the kidneys is disrupted.

back 36

D) during periods of fasting.

front 37

The average life span of a red blood cell is

A) 24 hours.

B) 1 month.

C) 4 months.

D) about 1 year.

E) many years.

back 37

C) 4 months.

front 38

The function of red blood cells is to

A) carry oxygen from the cells to the lungs.

B) carry carbon dioxide from the lungs to the body's cells.

C) carry nutrients from the digestive system to the body's cells.

D) defend the body against infectious organisms.

E) carry oxygen to the cells and then carry away carbon dioxide.

back 38

E) carry oxygen to the cells and then carry away carbon dioxide.

front 39

Eileen is a strict vegan and therefore eats no animal products. She develops an anemia that her doctor thinks is caused by a nutritional deficiency. Which of the following is the likeliest candidate?

A) aplastic anemia

B) vitamin B12 deficiency

C) lack of intrinsic factor

D) vitamin K deficiency

E) vitamin B6 deficiency

back 39

B) vitamin B12 deficiency

front 40

In adults, the only site of red blood cell production, and the primary site of white blood cell formation, is the

A) liver.

B) spleen.

C) thymus.

D) red bone marrow.

E) yellow bone marrow.

back 40

D) red bone marrow.

front 41

Each heme ring in hemoglobin encloses an atom of

A) magnesium.

B) calcium.

C) iron.

D) sodium.

E) copper.

back 41

C) iron.

front 42

Excess iron is stored in the liver and spleen as

A) transferrin.

B) hemosiderin.

C) ferritin.

D) hemoglobin.

E) hemosiderin and ferritin.

back 42

E) hemosiderin and ferritin.

front 43

In which of the following situations would you expect the blood level of bilirubin to be elevated?

A) during coagulation

B) an alcoholic with a damaged liver

C) iron-deficient diet

D) low hematocrit

E) low blood volume

back 43

B) an alcoholic with a damaged liver

front 44

If bile ducts are blocked,

A) more bilirubin appears in the plasma.

B) bilirubin appears in the saliva.

C) more hemolysis takes place.

D) more red blood cells are produced.

E) more white blood cells are produced.

back 44

A) more bilirubin appears in the plasma.

front 45

More than 95 percent of the protein in a red blood cell is

A) albumin.

B) porphyrin.

C) hemoglobin.

D) immunoglobulin.

E) fibrinogen.

back 45

C) hemoglobin.

front 46

The function of hemoglobin is to

A) carry dissolved blood gases.

B) carry bicarbonate ion.

C) aid in the process of blood clotting.

D) produce antibodies.

E) stimulate erythropoiesis.

back 46

A) carry dissolved blood gases.

front 47

________ is a condition in which the oxygen-carrying capacity of the blood is reduced.

A) Polycythemia

B) Leukemia

C) Anemia

D) Leukopenia

E) Thrombocytopenia

back 47

C) Anemia

front 48

Pernicious anemia caused by a lack of intrinsic factor is specifically treated by

A) oral doses of iron.

B) injections of iron.

C) oral doses of vitamin B12.

D) injections of vitamin B12.

E) blood transfusion.

back 48

D) injections of vitamin B12.

front 49

Which of the following would you expect to see in increased numbers in a peripheral blood sample after donating a unit of blood?

A) fibrocytes

B) platelets

C) reticulocytes

D) lymphocytes

E) neutrophils

back 49

C) reticulocytes

front 50

A red blood cell that contains excessive amounts of hemoglobin would be called

A) hyperchromic.

B) normochromic.

C) hypochromic.

D) normocytic.

E) macrocytic.

back 50

B) normochromic.

front 51

A bruise appears as a greenish spot in the skin because

A) hemoglobin has leaked from the blood into the injury and hemoglobin has a green color.

B) the heme group in the hemoglobin has broken down into biliverdin.

C) bilirubin from iron recycling has built-up in the bruise.

D) red blood cells are green when they leave circulation.

E) dead white blood cells accumulate at the site of injury.

back 51

B) the heme group in the hemoglobin has broken down into biliverdin.

front 52

Aged and damaged erythrocytes are broken down by macrophages in the

A) spleen.

B) liver.

C) bone marrow.

D) digestive tract.

E) spleen, liver, and bone marrow.

back 52

E) spleen, liver, and bone marrow.

front 53

The waste product bilirubin is produced from

A) globin chains of hemoglobin.

B) heme molecules plus iron.

C) heme molecules lacking iron.

D) iron found in hemoglobin molecules.

E) abnormal proteins found in red blood cells.

back 53

C) heme molecules lacking iron.

front 54

Most of the iron that is removed from degraded hemoglobin is

A) excreted by the kidneys.

B) excreted by the liver.

C) excreted by the intestines.

D) recycled to the red bone marrow.

E) stored in yellow bone marrow.

back 54

D) recycled to the red bone marrow.

front 55

In adults, erythropoiesis exclusively takes place in

A) the liver.

B) yellow bone marrow.

C) red bone marrow.

D) the spleen.

E) lymphoid tissue.

back 55

C) red bone marrow.

front 56

In adults, red bone marrow is located in the

A) sternum and ribs.

B) proximal epiphyses of long bones.

C) iliac crest.

D) body of vertebrae.

E) All of the answers are correct.

back 56

E) All of the answers are correct.

front 57

The process of red blood cell production is called

A) erythrocytosis.

B) erythropenia.

C) hemocytosis.

D) erythropoiesis.

E) hematopenia.

back 57

D) erythropoiesis.

front 58

The developmental stage at which erythrocytes enter the circulation is as

A) hemocytoblasts.

B) reticulocytes.

C) band forms.

D) myeloid cells.

E) proerythrocytes.

back 58

B) reticulocytes.

front 59

________ are immature erythrocytes that are present in the circulation.

A) Erythroblasts

B) Normoblasts

C) Myeloblasts

D) Band cells

E) Reticulocytes

back 59

E) Reticulocytes

front 60

Erythropoiesis is stimulated when

A) oxygen levels in the blood increase.

B) carbon dioxide levels in the blood decrease.

C) blood flow to the kidney declines.

D) coagulation begins.

E) blood pressure increases.

back 60

C) blood flow to the kidney declines.

front 61

Each hemoglobin molecule contains

A) four alpha chains.

B) one alpha and one beta chain.

C) four iron atoms.

D) one heme group.

E) a molecule of oxygen and a molecule of carbon dioxide.

back 61

C) four iron atoms.

front 62

The yellow color that is visible in the eyes and skin in jaundice results from

A) excessive amounts of bilirubin in the plasma.

B) extensive breakdown of RBCs.

C) destruction of hemoglobin.

D) the recycling of hemoglobin.

E) All of the answers are correct.

back 62

E) All of the answers are correct.

front 63

Which of the following blood count values would be a sign of anemia?

A) 10,000 WBC

B) 3.5 million RBC

C) 400,000 platelets

D) 5.5 million RBC

E) A and D taken together

back 63

B) 3.5 million RBC

front 64

After donating 0.5 liters of blood, one would expect

A) an increased reticulocyte count.

B) an increased platelet count.

C) an increased erythrocyte count.

D) an increased neutrophil count.

E) increased levels of clotting factors.

back 64

A) an increased reticulocyte count.

front 65

Bill wants to determine his blood type, so he takes a few drops of blood from a puncture wound in his finger and mixes it with various antisera. His blood cells agglutinate when mixed with the anti-A sera but not with the anti-B or anti-D sera. What does this mean?

A) Bill could receive type B-negative blood in a transfusion.

B) Bill could donate blood to an individual with type O blood.

C) Bill is Rh positive.

D) Bill's plasma contains B antibodies.

E) Bill's red blood cells contain the O surface antigen.

back 65

D) Bill's plasma contains B antibodies.

front 66

A person's blood type is determined by the

A) size of the RBCs.

B) volume of the RBCs.

C) chemical character of the hemoglobin.

D) presence of specific glycoproteins on the cell membrane.

E) shape of the RBCs.

back 66

D) presence of specific glycoproteins on the cell membrane.

front 67

People with type AB blood are considered the "universal recipient" for transfusions because

A) their blood cells lack A and B antigens.

B) their blood lacks A or B agglutinins.

C) their blood is plentiful in A and B agglutinins.

D) they usually have very strong immune systems.

E) they are usually Rh negative.

back 67

B) their blood lacks A or B agglutinins.

front 68

Blood type is identified primarily by

A) the Kahn blood group.

B) the HB blood system.

C) the Rh blood group.

D) both the ABO and Rh blood groups.

E) the ABO blood group.

back 68

D) both the ABO and Rh blood groups.

front 69

Type AB blood has which of the following characteristics?

A) RBCs have the Rh positive antigens and the anti-D plasma antibodies.

B) RBCs have no surface antigens and both anti-A and anti-B antibodies in the plasma.

C) RBCs have both the A & B surface antigens and no ABO plasma antibodies.

D) RBCs have the A and the B surface antigens and the plasma has anti-A and anti-B antibodies.

E) RBCs have the A antigen and the plasma has the anti-B antibody.

back 69

C) RBCs have both the A & B surface antigens and no ABO plasma antibodies.

front 70

Anti-D antibodies are present in the blood of

A) all individuals with type AB blood.

B) Rh negative individuals who have been exposed to the D surface antigen.

C) all Rh positive individuals.

D) Rh positive individuals who have been exposed to the D surface antigen.

E) all Rh negative individuals.

back 70

B) Rh negative individuals who have been exposed to the D surface antigen.

front 71

Antigens of the surface of red blood cells are also called ________ and antibodies in the blood plasma are also called ________.

A) agglutinins; agglutinogens

B) agglutinogens; agglutinins

C) T-cells; B-cells

D) erythrogens; antibiotics

E) serum; plasma

back 71

B) agglutinogens; agglutinins

front 72

Which of the following combinations may result in the hemolytic disease of the newborn?

A) mother Rh positive, baby Rh negative

B) mother Rh negative, baby Rh negative

C) mother Rh negative, baby Rh positive

D) mother type A+, baby type O+

E) None of the answers is correct.

back 72

C) mother Rh negative, baby Rh positive

front 73

The process of lymphopoiesis goes on in all of the following organs, except

A) the spleen.

B) the kidney.

C) the lymph nodes.

D) the red bone marrow.

E) the thymus.

back 73

B) the kidney.

front 74

Granulocytes form in

A) the intestines.

B) the spleen.

C) the thymus.

D) red bone marrow.

E) yellow bone marrow.

back 74

D) red bone marrow.

front 75

All of the following are true of neutrophils except that they are

A) granular leukocytes.

B) phagocytic.

C) also known as polymorphonuclear leukocytes.

D) important in coagulation.

E) active in fighting bacterial infections.

back 75

D) important in coagulation.

front 76

The most numerous white blood cells in peripheral circulation are the

A) neutrophils.

B) eosinophils.

C) basophils.

D) lymphocytes.

E) monocytes.

back 76

A) neutrophils.

front 77

White blood cells that release histamine at the site of an injury are

A) neutrophils.

B) eosinophils.

C) basophils.

D) lymphocytes.

E) monocytes.

back 77

C) basophils.

front 78

________ are large phagocytic white cells that spend most of their time outside the blood as fixed and free phagocytic cells.

A) Neutrophils

B) Eosinophils

C) Basophils

D) Lymphocytes

E) Monocytes

back 78

E) Monocytes

front 79

Which of the following descriptions best matches the term colony stimulating factor?

A) adheres to collagen beneath endothelium

B) helper cells are one type

C) hormone that regulates white blood cell formation

D) kills bacteria using hydrogen peroxide

E) often elevated in allergic individuals

back 79

C) hormone that regulates white blood cell formation

front 80

White blood cells that are increased in allergic individuals are the

A) neutrophils.

B) eosinophils.

C) basophils.

D) lymphocytes.

E) monocytes.

back 80

B) eosinophils.

front 81

A hormone that stimulates production of granulocytes and monocytes is

A) M-CSF.

B) G-CSF.

C) GM-CSF.

D) multi-CSF.

E) thymosin.

back 81

C) GM-CSF.

front 82

A genetically engineered hormone that stimulates the production of neutrophils is

A) M-CSF.

B) G-CSF (Neupogen).

C) GM-CSF.

D) multi-CSF.

E) thymosin.

back 82

B) G-CSF (Neupogen).

front 83

The most numerous WBCs in a differential count of a healthy individual are

A) neutrophils.

B) basophils.

C) lymphocytes.

D) monocytes.

E) leukocytes.

back 83

A) neutrophils.

front 84

Which of the following is not true of neutrophils?

A) less abundant than lymphocytes

B) can make hydrogen peroxide

C) can exit capillaries

D) can destroy bacteria

E) attracted to complement-coated bacteria

back 84

A) less abundant than lymphocytes

front 85

Which of these descriptions best matches the term B lymphocytes?

A) adhere to collagen beneath endothelium

B) helper cells are one type

C) develop into plasma cells

D) kill bacteria using hydrogen peroxide

E) often elevated in allergic individuals

back 85

C) develop into plasma cells

front 86

Which of the following is true of basophils?

A) constitute about 1 percent of WBCs

B) granules contain heparin

C) granules contain histamine

D) attract other defense cells

E) All of the answers are correct.

back 86

E) All of the answers are correct.

front 87

Which of these descriptions best matches the term T lymphocytes?

A) adhere to collagen beneath endothelium

B) are involved in cell mediated immunity

C) produce antibodies in response to antigens

D) kill bacteria using hydrogen peroxide

E) often elevated in allergic individuals

back 87

B) are involved in cell mediated immunity

front 88

An infected wound contains typically contains

A) dead neutrophils.

B) cellular debris.

C) tissue fluids.

D) pus.

E) All of the answers are correct.

back 88

E) All of the answers are correct.

front 89

Which of the following is not true of monocytes?

A) about same size as basophils

B) enter tissues and wander

C) become macrophages

D) are long-lived

E) can phagocytize bacteria

back 89

A) about same size as basophils

front 90

Eosinophils function in

A) destroying antibody-labeled antigens.

B) blood coagulation.

C) production of surface antigens for red blood cells.

D) antibody production.

E) production of heparin.

back 90

A) destroying antibody-labeled antigens.

front 91

During a bacterial infection you would expect to see increased numbers of

A) neutrophils.

B) eosinophils.

C) basophils.

D) reticulocytes.

E) thrombocytes.

back 91

A) neutrophils.

front 92

The blood cells involved in specific immunity are the

A) neutrophils.

B) monocytes.

C) basophils.

D) erythrocytes.

E) lymphocytes.

back 92

E) lymphocytes.

front 93

Non-specific immunity, such as phagocytosis, is a function of which blood cells?

A) basophils and eosinophils

B) neutrophils, eosinophils, and monocytes

C) lymphocytes and monocytes

D) platelets

E) lymphocytes

back 93

B) neutrophils, eosinophils, and monocytes

front 94

Which of the following is true of eosinophils?

A) Granules stain with eosin dyes.

B) Allergic patients have many.

C) They have bilobed nucleus.

D) They constitute about 2 to 4 percent of WBCs.

E) All of the answers are correct.

back 94

E) All of the answers are correct.

front 95

A patient has an infected puncture wound to her foot. Which type of white blood cell would you expect to be elevated in a differential white cell count?

A) neutrophils

B) eosinophils

C) basophils

D) lymphocytes

E) monocytes

back 95

A) neutrophils

front 96

The function of platelets is to assist in the

A) destruction of bacteria.

B) process called hemostasis.

C) removal of worn out red blood cells.

D) immune response during an infection.

E) transport of blood gases such as oxygen.

back 96

B) process called hemostasis.

front 97

Platelets are pinched off from giant multinucleated cells in the bone marrow called

A) erythroblasts.

B) normoblasts.

C) megakaryocytes.

D) myeloblasts.

E) lymphoblasts.

back 97

C) megakaryocytes

front 98

Platelets are

A) red cells that lack a nucleus.

B) blue cells that have a nucleus.

C) large cells with a prominent, concave nucleus.

D) tiny cells with a polynucleus.

E) cytoplasmic fragments of large cells.

back 98

E) cytoplasmic fragments of large cells.

front 99

In case of hemorrhage, platelets are stored as a reserve in the _______.

A) the heart.

B) the kidneys.

C) the spleen.

D) the thymus gland.

E) bone marrow.

back 99

C) the spleen.

front 100

Which of the following descriptions best matches the function of platelets?

A) adhere to collagen beneath endothelium

B) helper cells are one type

C) produce antibodies in response to antigens

D) kill bacteria using hydrogen peroxide

E) often elevated in allergic individuals

back 100

A) adhere to collagen beneath endothelium

front 101

A person whose platelet count is 40,000/µl is suffering from _______.

A) thrombocytosis.

B) leukocytosis.

C) hemocytosis.

D) thrombocytopenia.

E) leukopenia.

back 101

D) thrombocytopenia.

front 102

________ involves a cascade of reactions leading to the conversion of fibrinogen to fibrin.

A) Vascular spasm

B) The platelet phase

C) Retraction

D) Coagulation

E) Fibrinolysis

back 102

D) Coagulation

front 103

Most of the protein factors that are required for clotting are synthesized by the _______.

A) platelets.

B) megakaryocytes.

C) the liver.

D) the kidneys.

E) the spleen.

back 103

C) the liver.

front 104

The extrinsic pathway of coagulation is initiated by

A) sticking of platelets to damaged tissue.

B) activation of Factor VII exposed to collagen.

C) release of tissue factor (Factor III) by damaged endothelium.

D) release of heparin from the liver.

E) conversion of prothrombin to thrombin.

back 104

C) release of tissue factor (Factor III) by damaged endothelium.

front 105

The intrinsic pathway of coagulation is activated by the

A) sticking of platelets to damaged tissue.

B) activation of Factor XII exposed to collagen.

C) release of tissue factor (Factor III) by damaged endothelium.

D) release of heparin from the liver.

E) conversion of prothrombin to thrombin.

back 105

B) activation of Factor XII exposed to collagen.

front 106

The common pathway of coagulation begins with the

A) sticking of platelets to damaged tissue.

B) activation of a proenzyme exposed to collagen.

C) release of tissue factor by damaged endothelium.

D) conversion of Factor X to prothrombinase.

E) conversion of fibrinogen to fibrin.

back 106

D) conversion of Factor X to prothrombinase.

front 107

The process of fibrinolysis

A) activates fibrinogen.

B) draws torn edges of damaged tissue closer together.

C) dissolves clots.

D) forms emboli.

E) forms thrombi.

back 107

C) dissolves clots.

front 108

The enzyme that can digest fibrin and dissolve a clot is

A) thrombin.

B) plasmin.

C) heparin.

D) fibrinase.

E) phosphokinase.

back 108

B) plasmin.

front 109

Tissue factor (Factor III) is a factor in the ________ pathway.

A) extrinsic

B) intrinsic

C) common

D) retraction

E) fibrinolytic

back 109

A) extrinsic

front 110

Plasma thromboplastin is a factor in the ________ pathway.

A) extrinsic

B) intrinsic

C) common

D) retraction

E) fibrinolytic

back 110

B) intrinsic

front 111

Some rat poisons contain a toxin that blocks the liver's ability to utilize vitamin K. Animals that consume this poison would die of _______.

A) anemia.

B) acidosis.

C) hemorrhage.

D) thrombocytopenia.

E) starvation.

back 111

C) hemorrhage.

front 112

A substance that activates plasminogen might be useful to

A) cause clots to form faster.

B) cause clot dissolution to proceed faster.

C) initiate clot formation.

D) mimic heparin.

E) recruit neutrophils to an infection.

back 112

B) cause clot dissolution to proceed faster.

front 113

How would removal of calcium ions from a blood sample affect coagulation?

A) the coagulation pathway would be more sensitive to activation

B) coagulation would be prevented

C) no important effect because magnesium can substitute for calcium

D) coagulation would occur only in Rh positive individuals

E) more blood cells would be produced

back 113

B) coagulation would be prevented

front 114

Which of the following vitamins is needed for the formation of clotting factors?

A) vitamin A

B) vitamin B

C) vitamin K

D) vitamin D

E) vitamin E

back 114

C) vitamin K

front 115

A moving blood clot is called a(n) _______.

A) embolus.

B) thrombus.

C) plaque.

D) procoagulant.

E) platelet plug.

back 115

A) embolus.

front 116

Areas in a vessel wall where large quantities of lipid accumulate are called _______.

A) thrombi.

B) emboli.

C) plaques.

D) clots.

E) occlusions.

back 116

C) plaques.

front 117

People who suffer from hemophilia A fail to produce a functional Factor VIII; as a result

A) they lack a functional intrinsic pathway.

B) they lack a functional extrinsic pathway.

C) they lack a functional common pathway.

D) their coagulation times are much longer than normal.

E) their coagulation times are too quick.

back 117

A) they lack a functional intrinsic pathway.

front 118

Which of the following are common sources of vitamin K?

A) green vegetables

B) organ meats

C) whole grains

D) intestinal bacteria

E) All of answers are correct.

back 118

E) All of answers are correct.

front 119

The conversion of fibrinogen to fibrin is catalyzed by the enzyme _______.

A) fibrinogen-converting enzyme.

B) plasmin.

C) factor VIII.

D) thrombin.

E) prothrombinase.

back 119

D) thrombin.

front 120

A digestive disorder that impairs a person's ability to absorb vitamin K will result in

A) low levels of prothrombin.

B) low levels of Factor X.

C) low levels of thromboplastin.

D) prolonged bleeding.

E) All of the answers are correct.

back 120

E) All of the answers are correct.

front 121

Hormones called ________ are involved in regulation of white blood cell populations.

A) erythropoietin

B) bilirubin

C) thrombopoietin

D) colony-stimulating factors

E) plasmin

back 121

D) colony-stimulating factors

front 122

The ________ is a procedure that is used to determine the number of each of the various types of white blood cells.

A) differential count

B) hematocrit

C) sedimentation rate

D) WBC count

E) complete cell count (CBC)

back 122

A) differential count

front 123

Fifty to seventy percent of circulating white blood cells are _______.

A) monocytes.

B) lymphocytes.

C) eosinophils.

D) basophils.

E) neutrophils.

back 123

E) neutrophils.

front 124

The phase of hemostasis that involved clotting of blood is called

A) coagulation.

B) hemolysis.

C) vascular spasm.

D) a platelet plug.

E) diapedesis.

back 124

A) coagulation.

front 125

Plasminogen is converted to its active form by an enzyme called

A) tissue plasminogen activator.

B) papain.

C) fibrinolysin.

D) prothrombin.

E) polymerase.

back 125

A) tissue plasminogen activator.

front 126

Endothelial cells release ________ that stimulate smooth muscle contraction and accelerate the repair process.

A) platelets

B) endothelins

C) histamines

D) CSFs

E) heparins

back 126

B) endothelins

front 127

The process of fibrinolysis

A) activates fibrinogen.

B) draws torn edges of damaged tissue closer together.

C) dissolves clots.

D) forms emboli.

E) forms thrombi.

back 127

C) dissolves clots.

front 128

The enzyme that can digest fibrin and dissolve a clot is

A) thrombin.

B) plasmin.

C) heparin.

D) fibrinase.

E) phosphokinase.

back 128

B) plasmin.