1) A commensal bacterium
A) does not receive any benefit from its host.
B) is beneficial to its host.
C) may also be an opportunistic pathogen.
D) isnt capable of causing disease in its host.
E) always causes disease in its host.
C) may also be an opportunistic pathogen.
2) Which of the following statements is TRUE?
A) Both members are harmed in a symbiotic relationship.
B) Members of a symbiotic relationship cannot live without each other.
C) A parasite is not in symbiosis with its host.
D) Symbiosis always refers to different organisms living together and benefiting from each other.
E) At least one member must benefit in a symbiotic relationship.
E) At least one member must benefit in a symbiotic relationship.
3) A nosocomial infection is
A) always present, but is inapparent at the time of hospitalization.
B) acquired during the course of hospitalization.
C) always caused by medical personnel.
D) only a result of surgery.
E) always caused by pathogenic bacteria.
B) acquired during the course of hospitalization.
4) The major significance of Robert Kochs work is that
A) microorganisms are present in a diseased animal.
B) diseases can be transmitted from one animal to another.
C) microorganisms can be cultured.
D) microorganisms cause disease.
E) microorganisms are the result of disease.
D) microorganisms cause disease.
5) Which of the following is NOT a verified exception in the use of Kochs postulates?
A) Some diseases have poorly defined etiologies.
B) Some pathogens can cause several disease conditions.
C) Some human diseases have no other known animal host.
D) Some diseases are not caused by microbes.
E) Some diseases are noncommunicable.
E) Some diseases are noncommunicable.
6) Which of the following diseases is NOT spread by droplet infection?
A) botulism
B) tuberculosis
C) measles
D) the common cold
E) diphtheria
A) botulism
7) Biological transmission differs from mechanical transmission in that biological transmission
A) occurs when a pathogen is carried on the feet of an insect.
B) involves fomites.
C) involves reproduction of a pathogen in an arthropod vector prior to transmission.
D) requires direct contact.
E) works only with noncommunicable diseases.
C) involves reproduction of a pathogen in an arthropod vector prior to transmission.
8) Which of the following definitions is INCORRECT?
A) endemic: a disease that is constantly present in a population
B) epidemic: a disease that is endemic across the world
C) pandemic: a disease that affects a large number of people in the world in a short time
D) sporadic: a disease that affects a population occasionally
E) incidence: number of new cases of a disease
B) epidemic: a disease that is endemic across the world
9) Focal infections initially start out as
A) sepsis.
B) bacteremia.
C) local infections.
D) septicemia.
E) systemic infections.
C) local infections.
10) The rise in herd immunity amongst a population can be directly attributed to
A) increased use of antibiotics.
B) improved handwashing.
C) vaccinations.
D) antibiotic-resistant microorganisms.
E) None of the answers is correct.
C) vaccinations.
11) Koch observed Bacillus anthracis multiplying in the blood of cattle. What is this condition called?
A) bacteremia
B) focal infection
C) local infection
D) septicemia
E) systemic infection
D) septicemia
12) Which one of the following does NOT contribute to the incidence of nosocomial infections?
A) antibiotic resistance
B) lapse in aseptic techniques
C) gram-negative cell walls
D) lack of handwashing
E) lack of insect control
C) gram-negative cell walls
13) Transient microbiota differ from normal microbiota in that transient microbiota
A) cause diseases.
B) are found in a certain location on the host.
C) are always acquired by direct contact.
D) are present for a relatively short time.
E) never cause disease.
D) are present for a relatively short time.
14) Which of the following statements about nosocomial infections is FALSE?
A) They occur in compromised patients.
B) They may be caused by opportunists.
C) They may be caused by drug-resistant bacteria.
D) They may be caused by normal microbiota.
E) The patient was infected before hospitalization.
E) The patient was infected before hospitalization.
Answer: E
15) One effect of washing regularly with antibacterial agents is the removal of normal microbiota. This can result in
A) body odor.
B) fewer diseases.
C) increased susceptibility to disease.
D) normal microbiota returning immediately.
E) no bacterial growth because washing removes their food source.
C) increased susceptibility to disease.
16) Which of the following is NOT a reservoir of infection?
A) a sick person
B) a healthy person
C) a sick animal
D) a hospital
E) None of the answers is correct; all of these can be reservoirs of infection.
E) None of the answers is correct; all of these can be reservoirs of infection.
17) Which of the following is NOT a communicable disease?
A) malaria
B) AIDS
C) tuberculosis
D) tetanus
E) typhoid fever
D) tetanus
18) Which of the following is a fomite?
A) water
B) droplets from a sneeze
C) pus
D) insects
E) a hypodermic needle
E) a hypodermic needle
19) Which of the following statements about biological transmission is FALSE?
A) The pathogen reproduces in the vector.
B) The pathogen may enter the host in the vectors feces.
C) Houseflies are an important vector.
D) The pathogen may be injected by the bite of the vector.
E) The pathogen may require the vector as a host.
C) Houseflies are an important vector.
20) Which of the following definitions is INCORRECT?
A) acute: a short-lasting primary infection
B) inapparent: infection characteristic of a carrier state
C) chronic: a disease that develops slowly and lasts for months
D) primary infection: an initial illness
E) secondary infection: a long-lasting illness
E) secondary infection: a long-lasting illness
21) Symptoms of disease differ from signs of disease in that symptoms
A) are changes felt by the patient.
B) are changes observed by the physician.
C) are specific for a particular disease.
D) always occur as part of a syndrome.
E) None of the answers is correct.
A) are changes felt by the patient.
22) The science that deals with when diseases occur and how they are transmitted is called
A) ecology.
B) epidemiology.
C) communicable disease.
D) morbidity and mortality.
E) public health.
B) epidemiology.
Figure 14.1 shows the incidence of influenza during a typical year. Which letter on the graph indicates the endemic level?
A) a
B) b
C) c
D) d
E) The answer cannot be determined based on the information provided.
D) d
24) Emergence of infectious diseases can be attributed to all of the following EXCEPT
A) antibiotic resistance.
B) climatic changes.
C) new strains of previously known agents.
D) ease of travel.
E) The emergence of infectious diseases can be attributed to all of these.
E) The emergence of infectious diseases can be attributed to all of these.
25) Which of the following pairs is mismatched?
A) malaria vector
B) salmonellosis vehicle transmission
C) syphilis direct contact
D) influenza droplet infection
E) None of the pairs is mismatched.
E) None of the pairs is mismatched.
26) Which of the following can contribute to postoperative infections?
A) using syringes more than once
B) normal microbiota on the operating room staff
C) errors in aseptic technique
D) antibiotic resistance
E) All of the answers are correct.
E) All of the answers are correct.
In Figure 14.2, when is the prevalence the highest?
A) July
B) January
C) February
D) March
E) The answer cannot be determined based on the information provided.
C) February
28) A cold transmitted by a facial tissue is an example of
A) direct contact.
B) droplet transmission.
C) fomite.
D) vector.
E) vehicle transmission.
E) vehicle transmission.
29) A researcher has performed a prospective study on a disease. To which specific kind of epidemiological study is this referring?
A) analytical
B) case control
C) descriptive
D) experimental
E) prodromal
C) descriptive
30) The CDC is located in
A) Atlanta, GA.
B) Washington, DC.
C) New York City, NY.
D) Los Angeles, CA.
E) Chicago, IL.
A) Atlanta, GA.
31) A disease in which the causative agent remains inactive for a time before producing symptoms is referred to as
A) subacute.
B) subclinical.
C) latent.
D) zoonotic.
E) acute.
C) latent.
32) A needlestick is an example of
A) direct contact.
B) droplet transmission.
C) indirect contact transmission by fomite.
D) direct biological transmission by vector.
E) vehicle transmission.
C) indirect contact transmission by fomite.
33) Which of the following is NOT a predisposing factor of disease?
A) lifestyle
B) genetic background
C) climate
D) occupation
E) All of these are predisposing factors of disease.
E) All of these are predisposing factors of disease.
34) In which of the following diseases can gender be considered a viable predisposing factor?
A) urinary tract infections
B) pneumonia
C) salmonellosis
D) tetanus
E) anthrax
A) urinary tract infections
35) In which of the following patterns of disease does the patient experience no signs or symptoms?
A) prodromal
B) decline
C) convalescence
D) incubation
E) both incubation and convalescence
E) both incubation and convalescence
During a six-month period, 239 cases of pneumonia occurred in a town of 300 people. A clinical case was defined as fever 39C lasting >2 days with three or more symptoms (i.e., chills, sweats, severe headache, cough, aching muscles/joints, fatigue, or feeling ill). A laboratory-confirmed case was defined as a positive result for antibodies against Coxiella burnetii. Before the outbreak, 2000 sheep were kept northwest of the town. Of the 20 sheep tested from the flock, 15 were positive for C. burnetii antibodies. Wind blew from the northwest, and rainfall was 0.5 cm compared with 7 to 10 cm during each of the previous three years.
36) Situation 14.1 is an example of
A) human reservoirs.
B) a zoonosis.
C) a nonliving reservoir.
D) a vector.
E) a focal infection.
B) a zoonosis.
37) The etiologic agent of the disease in Situation 14.1 is
A) sheep.
B) soil.
C) Coxiella burnetii.
D) pneumonia.
E) wind.
C) Coxiella burnetii.
38) The method of transmission of the disease in Situation 14.1 was
A) direct contact.
B) droplet.
C) indirect contact.
D) vector-borne.
E) vehicle.
E) vehicle.
39) Which of the following is NOT an example of microbial antagonism?
A) acid production by bacteria
B) bacteriocin production
C) bacteria occupying host receptors
D) bacteria causing disease
E) bacteria producing vitamin K
D) bacteria causing disease
40) The yeast Candida albicans does not normally cause disease because of
A) symbiotic bacteria.
B) antagonistic bacteria.
C) parasitic bacteria.
D) commensal bacteria.
E) other fungi.
B) antagonistic bacteria.
41) If a prodromal period exists for a certain disease, it should occur prior to
A) incubation.
B) illness.
C) decline.
D) convalescence.
B) illness.
42) Which one of the following is NOT a zoonosis?
A) cat-scratch disease
B) Hantavirus pulmonary syndrome
C) rabies
D) tapeworm
E) All of these are zoonoses.
E) All of these are zoonoses.
43) Pseudomonas bacteria colonized the bile duct of a patient following his liver transplant surgery. This is an example of a
A) communicable disease.
B) latent infection.
C) nosocomial infection.
D) sporadic disease.
C) nosocomial infection.
44) Figure 14.3
The graph in Figure 14.3 shows the incidence of polio in the United States. The period between 1945 and 1955 indicates a(n)
A) endemic level.
B) epidemic level.
C) sporadic infection.
D) communicable disease.
E) pandemic.
B) epidemic level.
45) Which of the following statements is FALSE?
A) Antimicrobial therapy for hemodialysis-associated infections increases antibiotic resistance.
B) S. aureus is differentiated from other mannitol+ cocci by the coagulase test.
C) The M in MRSA stands for mannitol.
D) The USA100 strain accounts for most hospital-acquired MRSA.
E) The USA300 strain accounts for most community-acquired MRSA.
C) The M in MRSA stands for mannitol.
1) For a particular disease at a specific time period, morbidity rates should always be equal or greater than mortality rates.
Answer: TRUE
2) Testing the effectiveness of a new drug for anthrax would be best performed as an experimental study.
Answer: TRUE
3) MMWR is a publication by the CDC that reports on only emerging diseases.
Answer: FALSE
4) A researcher only needs to select a cohort group when implementing an analytical epidemiological study.
Answer: FALSE
5) Diseases that are referred to as emerging infectious diseases have only been discovered in the past fifty years.
Answer: FALSE
6) Compromised hosts are always suffering from suppressed immune systems.
Answer: FALSE
7) A host is not considered diseased until an infection changes ones state of health.
Answer: TRUE
8) Reservoirs of infections are always animate objects.
Answer: FALSE
9) Urinary tract infections are the most common forms of nosocomial infections.
Answer: FALSE
10) Both normal and transient flora can become opportunistic pathogens.
Answer: TRUE
an abnormal state in which the body is not performing normal functions
Disease
analyzes relationships between microbial communities on the body and human health
Human Microbiome Project
one organism benefits at the expense of the other
parasitism
also known as blood poisoning; growth of bacteria in the blood
Septicima
spreads to a host by a nonliving object called a fomite
Indirect contact transmission:
the study of disease
pathology
the development of disease
pathogenesis
invasion or colonization of the body by pathogens
Infection
may be present for days, weeks, or months
transient microbiota
a competition between microbes
Microbial antagonism (competitive exclusion)
one organism benefits, and the other is unaffected
commensalism
both organisms benefit
mutualism
number of people who develop a disease during a particular time period
incedence
number of people who develop a disease at a specified time,
regardless of when it first appeared
Takes into account both old
and new cases
prevalence
worldwide epidemic
pandemic disease
symptoms develop slowly
chronic disease
toxins in the blood
Toxemia
interval between initial infection and first signs and symptoms
Incubation period:
disease is most severe
Period of illness:
signs and symptoms subside
Period of decline:
are diseases transmitted from animals to humans
animal reservoirs (zoonoses)
an individual whose resistance to infection is impaired by disease, therapy, or burns
Compromised host:
number of people affected in relation to the total population in a given time period
Morbidity rate:
number of deaths from a disease in relation to the population in a given time
Mortality rate:
diseases in which physicians are required to report occurrence
Notifiable infectious diseases:
Body returns to its predeceased state
period of convalescence
The science that deals with when disease occurs and how they are transmitted is called?
Epidimeology
A researcher has performed a prospective study on a disease to which specific kind of epidemiological study is this referring
Descriptive
Pathogen reproduces in the vector; transmitted via bites or feces
biological transmission
Symptoms develop rapidly, but the disease lasts only a short time
acute disease
Permanently colonize the host and do not cause disease under normal conditions
Normal microbiota
A disease that is spread from one host to another
Communicable disease
Disease constantly present in a poulation
Endemic
Disease acquired by many people in a given area in a short time
Epidemic
Changes in the body that can be measured or observed as a result of disease
Signs
no noticeable signs or symptoms (inapparent infection)
Subclinical disease
Toxic inflammatory condition arising from the spread of microbes especially bacteria or their toxins, from a focus infection.
Sepsis
Viruses in the blood
Viremia
A specific group of signs and symptoms that accompany disease
Syndrome
Pathogens are limited to a small area of the body
Local infection
Number of people who develop disease during a particular time period
Incedence
Requires close association between the infected and susceptible host
Direct contact transmission
Opportunistic infection after a primary (predisposing) infection
Secondary infection
One organism benefits at the expense of the other
Parasatism
May have inapparent infection or latent disease
Carriers (human reservoirs)
The cause of disease
Etiology
Is the relationship between normal microbiota and the host
Symbiosis
Transmission by an inanimate reservoir; waterborne, food borne,airborn
Vehicle transmission
the study of disease
Pathology
Intermediate between acute and chronic
Subacute disease
Soil and water
Non living reservoirs
May be present for days weeks or months
Transient microbiota
Short period after incubation; early mild symptoms
Prodromal perdiod
An infection throughout the body
Systemic generalized
Invasion or colonization of the body by pathogens
infection
Arthropods carry pathogens on its feet
Mechanical transmission
Immunity in most of a population
herd immunity