Lymph nodes contain:
- Macrophages
- B cells
- T cells
Sepsis
systemic inflammatory response
Septicema
pathogens/toxins in blood
Severe sepsis
sepsis + decreased blood pressure
Septic shock
sepsis + uncontrollable decreased blood pressure
Lymphangitis
- Inflammed lymph vessels
- accompany septicemia & septic shock
gram-NEGATIVE sepsis (ENDOtoxins)
- septic shock
- ENDOTOXINS - decrease blood pressure
- antibiotics can worsen
Treatment for gram-NEGATIVE sepsis
protein C (anti-coagulant)
gram-POSITIVE sepsis (EXOtoxins)
Nosocomial infections
- antibiotic-resistant
nosocomial infections
- S. aureus
- S. pyogenes
- S. agalactiae (group B strep)
- E. faecalis
Puerperal Sepsis (Childbirth Fever)
S. pyogenes
Bacterial infections of the heart
- Endocarditis
- Subacute bacterial endocarditis
- Acute bacterial endocarditis
- Pericarditis
Endocarditis
(inner layer of heart)
Inflammation of the endocardium
Acute Bacterial Endocarditis
S. aureus
- from mouth
Sub-acute Bacterial Endocarditis
Strep
- from mouth
Pericarditis
Strep
Rheumatic fever is an autoimmune complication of
S. pyogenes infections (strep throat)
- inflammed heart valves
Tularemia
"rabbit fever"
Francisella tularensis
- zoonosis (rabbits/deer)
Tularemia is transmitted by:
deer fly (vector)
Brucellosis
"undulant fever"
Brucella
- grow in phagocytes
- fever spikes each evening
Brucellosis is transmitted via
milk or direct contact with infected animal
Brucellosis:
- B. abortus
elk, bison, cows
Brucellosis:
- B. suis
swine
Brucellosis:
- B. melitensis
goats, sheep, camels
Anthrax
Bacillus anthracis
- found in soil (aerobe)
- cattle routinely vaccinated
Gastrointestinal (GI) anthrax
- ingest bad food
- 50% mortality
Inhalation (pulmonary) anthrax
- inhale endospores
- 100% mortality
Gas gangrene
Clostridium perfingens
- grows in necrotic tissue
ischemia
loss of blood supply to tissue
Necrosis
death of tissue
Gangrene
death of soft tissue
Systemic Diseases caused by bites & scratches
- Bacteroides
- Bartonella henselae
- Clostridium
- Fusobacterium
- Pasturella multocida
Bartonella henselae
Cat Scratch Disease
Vector- transmitted Diseases:
- Reservoir: Rodents
- Vector: Arthropods (tick, flea)
- Plague
- Relapsing fever
- Lyme disease
- Typhus
Plague
Yersinia pestis
Bubonic plague
bacterial growth in blood & lymph
Septicemia plague
septic shock
Pneumonic plague
bacteria in the lungs
Relapsing Fever
Borrelia
- ticks
T/F: successive relapses are less severe in Relapsing Fever?
True
Lyme Disease
Borrelia burgdorferi
- tick (vector)
Lyme Disease:
3 phases of symptoms
- Bull's-eye rash
- encephalitis, irregular heartbeat
- arthritis
Typhus
Rickettsia
- obligate parasites
Epidemic Typhus
R. prowazekii
- louse feces rub in wound
Endemic Murine Typhus
R. typhi
Rocky Mountain Spotted Fever
R. rickettsii
- rash on PALMS & SOLES of hands & feet
Viral Diseases of the Cardio & Lymph System:
- Burkitt's Lymphoma
- Infectious Mono
- CMV
- Chikungunya Fever
- Yellow Fever
- Dengue
- Marbug Fever
- Ebola
- Lassa Fever
- Hanta Pulmonary Syndrome
What 2 viruses are caused by the EB virus (HHV-4)
- Burkitt's Lymphoma
- Mono
Burkitt's Lymphoma
Epstein-Barr (EB) virus (HHV-4)
- nasopharyngeal cancer
- cancer in patients with Malaria or AIDS
Burkitt's Lymphoma cancer in immuno-suppressed patients with:
- AIDS
- Malaria
Mononucleosis (Mono)
Epstein-Barr (EB) virus (HHV-4)
- transmitted via saliva
Cytomegalovirus - CMV
HHV-5
- cells swell (WBC)
What are ways Cytomegalovirus is transmitted
- across the placenta (causes mental retardation)
- sex
- blood
- transplanted tissue
VIRAL Hemorrhagic Fevers:
- Yellow
- Dengue
- Marburg
- Ebola
- Lassa
- Argentine & Bolivian
- Hantavirus
Viral Hemorrhagic Fevers:
Yellow Fever & Dengue
Abroviruses
- transmitted via arthropods
Viral Hemorrhagic Fevers:
Marburg, Ebola, Lassa, Argentine, Bolivian, Whitewater Arroyo:
Filovirus & Arenavirus
- contact w/ blood
Viral Hemorrhagic Fevers:
Hantavirus
Bunyavirus
- inhalation of rodent excretions
Protozoan Diseases of the Cardio & Lymph System:
- Chaga's Disease
- Toxoplasmosis
- Malaria
Chaga's Disease (American Trypanosomiasis)
T. cruzi
- kissing bug
Toxoplasmosis
T. gondii
Toxoplasmosis is transmitted by
- bad food
- contact w/ cat feces
Congenital infection of Toxoplasmosis
- stillbirth
- neurological damage
Malaria
Plasmodium (protozoa parasite)
- P. vivax
- P.ovale
- P. malariae
- P. falciparum
Plasmodium - 4 forms
(malaria)
- P. vivax
- P.ovale
- P. malariae
- P. falciparum
The host & vector of Malaria
Anopheles MOSQUITO
*control with bed nets
Prevention (prophylaxis) of Malaria
- Chloroquine
- Malarone
- Mefloquine
Treatment for Malaria
Artemisin
Bacterial Biological Weapons
- Bacillus
- Brucella
- Chlaymdia
- Clostridium
- Francisella
- Rickettsia
- Shigella
- Vibrio
- Yersinia
Viral Biological Weapons
- Polio
- Measles
- Encephalitis
- Hemorrhagic fevers
- Influenza A
- Monkeypox
- Niphrah
- Smallpox
- Yellow Fever