Functions of respiration
Supply blood with 02 and dispose of C02
Four processes of respiration
Pulmonary ventilation, external respiration, transport, and internal respiration
Pulmonary Ventilation
(breathing) movement of air into and out of lungs
External Respiration
02 and C02 exchange between lungs and blood
Transport
02 and C02 in blood
Internal Repiration
02 and C02 exchange between systemic blood vessels and tissues
Conducting zone includes:
Conduits for air to reach sites of gas exchange
Nose, nasal cavity, pharynx, trachea, and bronchi
Respiratory zone includes:
Site of gas exchange
Bronchioles, alveolar ducts, and alveoli
Respiratory Muscles include:
diaphragm, external intercostal, and other muscles
Functions of the nose
Airway for respiration, moistening and warming air, filtering air, resonating chambers for speech, and housing olfactory receptors
The nose consists of
The external nose and the nasal cavity (entirely within the skull)
The nasal cavity consists of:
Olfactory and respiratory mucosa
Nares are:
Nostrils
Nasal Vestibule: location
Nasal cavity superior to nares
Vibrissae are:
Hairs that filter course particle from inspired air
Olfactory mucosa: location and function
Lines superior nasal cavity and contains olfactory recptors
Respiratory Mucosa: location and function
Lines the nasal cavity and contains lysozyme and definsins to destroy bacteria
Superior, middle, and inferior nasal chonchae function
Increase mucosal area, enhance air turbulence, and help filter and moisten air
Paranasal Sinuses: location and function
In frontal, sphenoid, ethmoid, and maxillary bones.
Lighten skull, warm and moisten air , and play a role in resonance of sound.
What is the pharynx?
Location
Includes
Funnel shaped tube of skeletal muscle that connects to the nasal cavity and mouth superiorly and larynx and esophagus inferiorly
Nasopharynx, oropharynx, and laryngopharynx
Nasopharynx
Serves only as an air passageway and contains pharyngeal tonsils
Oropharynx
Air and food passageway that extends inferiorly from soft palate to epiglottis
Laryngopharynx
Air and food passageway that lies posterior to the epiglottis, extends to the larynx, and continues inferiorly with the esophagus
Larynx: location and functions (3)
Attaches to hyphoid bone and opens into laryngopharynx superiorly and is continuous with the trachea inferiorly.
Airway, routes air and food into proper channels, and voice production
Epiglottis
Elastic cartilage that covers the larynx during swallowing
Larynx consists of
Hyaline cartilage, thyroid, cricoid, paired arytendoid, corniculate, cuneiform, and epiglottis.
Voice ligaments: location and composed of
Found in the larynx attached to arytendoid cartilage and thyroid cartilage
Elastic fibers that form mucosal called true vocal cords
What is the glottis? Its function?
The medial opening between voice ligaments.
They vibrate to produce sound as air rushed up from lungs
Vestibular folds form the:
Location
Function
False vocal cords
Superior to vocal folds
No part in sound production and help to close the glottis during swallowing
Speech
intermittent release of expired air while opening and closing the glottis
Pitch
determined by the length and tension of vocal cords
Loudness
depends upon force at which the air rushes across the vocal cords
Chambers of the pharynx, oral, nasal, and sinus cavities....
amplify and enhance sound quality
Sound is shaped into language by
muscles of the pharynx, tongue, soft palate, and lips
What is the trachea and where is it located?
Windpipe. From the larynx to the mediastinum
Composed of what 3 layers
Mucosa, Submucosa, and Adventitia
Mucosa
made up of goblet cells and pseudostratified ciliated epithelium
Submucosa
connective tissue deep in the mucosa
Adventitia
outermost layer made of c shaped rings of hyaline cartilage
Bronchial Tree: Location and includes?
Begins at trachea, ends at terminal bronchioles, and branches from trachea.
Secondary (lobar) bronchi, tertiary (segmental) bronchi, bronchioles, and terminal bronchioles
Respiratory Zone: Location
Respiratory bronchioles lead to
Begins as terminal bronchioles feed into respiratory bronchioles
Alveolar ducts, then to terminal clusters of alveolar sacs composed of alveoli
Alveoli: Amount and Function
Approximately 300 million and account for most of the lungs volume
Provide tremendous surface area for gas exchange
The air blood barrier is composed of
Pulmonary capillaries and alveolar walls and their fused basement membranes
Alveolar Walls
Single layer of epithelial cells that permit gas exchange by simple diffusion
Aveoli are...
Surrounded by fine elastic fibers, contain open pores, and have macrophages that keep their surface sterile
Lungs are found in the
Thoracic cavity, each lung is suspended in its own pleura cavity and connected to mediastinum via lung roots
Each lobe of the lungs contain
bronchopulmonary segments each served by its own artery, vein, and tertiary bronchus
Left lung
Oblique fissure
Divided into two lobe
Right lung
Oblique and horizontal fissures
Divided into three lobes
Lung tissue consists of
air spaces and elastic connective tissue
What are the 2 lung circulations
Pulmonary Network and Bronchial ateries
Pulmonary Network supplies
systemic blood to the lungs for oxygenation
Bronchial ateries
provide systemic blood to lung tissue
The lungs are innervated by
parasympathetic and sympathetic motor fibers and visceral sensory fibers that constrict and dilate airways
What is the pleura?
Parietal pleura?
Viceral pleura?
Thin double layered serosa
Covers thoracic wall, superior diaphragm, and continues around heart between the lungs
Covers external lungs surface and follows its contours and fissures
Inspiration
Expiration
Air flow into the lungs
Gases exit the lungs
Intrapulmonary pressure
pressure in the alveoli that rises and falls with respiration but always eventually equals out with atmospheric pressure
Intrapleural pressure
pressure within the pleura cavity that rises and falls during respiration but is always about 4 mm Hg less that intrapulmonary pressure
Pulmonary ventilation
mechanical process that causes gas to flow in and out of the lungs according to volume changes in the thoracic cavity
Boyles Law
states that at a constant temp. the pressure of gas varies inversely with its volume
During quiet inspiration
diaphragm and intercostals contract, resulting in an increase in thoracic volume, which causes intrapulmonary pressure to drop below atmospheric pressure, and air flows into the lungs
During forced inspiration
accessory muscles of the neck and thorax contract, increasing thoracic volume beyond the increase in volume during quiet respiration
Quiet expiration
passive process that relies mostly on elastic recoil of the lungs as the thoracic muscles relax
Forced expiration
active process relying on contraction of abdominal muscles to increase intrabdominal pressure and depress the rib cage
Air resistance
the friction encountered by air in the air passageways
As airway resistance increases
Gas flow is reduced
Alevolar surface tension due to water in the alveoli acts to
draw the walls of the alveoli together, presenting a force that must be overcome to expand the lungs
Lung compliance is determine by
Distensibility of lung tissue and thoracic cage as well as alveolar surface tension
Respiratory capacities evaluated by
Respiratory volumes and specific combinations of volumes
Tidal volume
amount of air that moves in and out of the lungs with each breath
Inspiratory reserve volume
amount of air that can be forcefully inspired beyond tidal volume
Expiratory reserve
amount of air that can be evacuated from the lungs after tidal expiration
Residual volume
amount of air that remains in the lungs after maximal forced expiration
Inspiratory capacity
sum of tidal and expiratory reserve and is the amount of volume that can be inspired after tidal expiration
Functional residual capcicty
combined residual volume and expiratory volume and is the amount of air that remains in the lungs after tidal expiration
Vital capacity
sum of tidal, inspiratory, expiratory reserve volumes and is the total amount of exchangeable air
Total lung capacity
total of all volumes
Anatomical dead space
volume of the conducting zone conduits and never contributes to gas exchange
Pulmonary function test
evaluates losses in respiratory function using a spirometer to distinguish between obtrusive and restrictive pulmonary disorders
Non respiratory air movements
cause movement of air in and out of lungs but are not related to breathing (coughing, sneezing, crying, laughing, hiccups, and yawning)
Dalton's law
total pressure exerted by a mixture of gasses is the sum of the pressure exerted by each gas in the mixture
Henry's Law
when a mixture of gases in in contact with a liquid each gas will dissolve in the liquid in proportion to its partial pressure
The composition of alveolar gas differs from atmospheric due to
Gas exchange occurring in the lungs, humidification of air due to conducting passages, and mixing of alveolar gas that occurs with each breath
External respiration is
02 uptake, and C02 unloading from hemoglobin in red blood cells
There is a partial gradient between blood in the alveoli and pulmonary arteries because however carbon dioxide moves in the on a gradient that is
steep; blood diffuses quickly from alveoli into blood
other direct; much less steep
The difference in the degree of the gradient of oxygen and carbon dioxide reflects that
carbon dioxide is much more soluble that oxygen in blood
Ventilation profusion coupling ensures
a close match between the amount of gas reaching the alveoli and the blood flow in pulmonary capilaries
Respiratory membrane is
very thin and presents a huge surface area for effcient gas exchange
For internal respiration the diffusion rate for oxygen and carbon dioxide are from external respiration and pulmonary gas exchange
reversed
What is the partial pressure of oxygen in tissues?
Carbon dioxide?
low so that oxygen diffuses readily into tissue
Similar to oxygen gradient but in the reverse direction
What % of oxygen is dissolved in plasma?
Where is the rest taken?
1.5%
Carried on hemoglobin
How many oxygen molecules can be carried on one hemoglobin?
4
Efficiency of hemoglobin oxygen transport
hemoglobin becomes more attracted to oxygen each time it loads and unloads making transport very efficent
At high plasma partial pressures of oxygen
At dramatically low plasma partial pressure of oxygen (vigorous exercise)
Very little oxygen is unloaded
Much more oxygen is unloaded to supply the tissues
What are the influences of hemoglobin's saturation at any given partial pressure?
Temp, blood ph, P C02, and the amount of BPG in blood
What are the ways that carbon dioxide is transported in the blood? (3)
7-10% dissolved is plasma, 20% carried on hemoglobin bound the globin, and 70% is bicarbonate
What is the medulla oblongata's role in breathing?
contains the dorsal and ventral respiratory groups
Dorsal respiratory group
Ventral respiratory group
Neurons that act as a pace setting for breathing
Functions mostly during forced breathing
What is the pon's role in breathing?
Contains the pontine respiratory group
Pontaine respiratory group
modifies the breathing rhythm and prevents overinflation of the lungs through inhibiting the medullary respiratory centers
Chronic Obtrusive Pulmonary Diseases: AKA
Common in patients who?
Results in?
COPD
Smoke
Dyspnea, coughing, frequent pulmonary infections, and respiratory failure
Obtrusive Emphysema
Chronic Bronchitis
Type of COPD: permanently enlarged alveoli and deterioration of alveolar walls
Type of COPD: excessive mucus production as well as inflamation and fibrosis of the lower respiratory mucosa
Asthma: What is is?
Caused by?
causes coughing, dyspnea, wheezing, and chest tightness caused by active inflammation of the airways
Tuberculosis: What is it?
Caused by?
Spread by?
infectious disease caused by bacterium mycobacterium tuberculosis and spread by coughing and inhalation
Lung Cancer: Common?
Correlated with?
It is the most common type of malignancy in both sexes
Smoking
Squamous cell carcinoma
Arises from epithelium of bronchi and causes masses that hollow out and bleed
Adenocarcinoma
Originates in peripheral lung areas as nodules that develop from bronchial glands and alveolar cells
Small cell carcinoma
Contains lymphocyte like cells that form clusters within the mediastinum and rapidly metastasize