Anatomy
Study of internal and external structures
ex: bones-femur
Protein fiber-collagen
Physiology
Study of function of cells, tissues organs. Example in a stressful situation cortisol is released.
Gross anatomy
Large structures, example femur
Histology
Study of tissues, example, adipose
Describe the levels of complexity, involved in living organisms, starting with atoms and ending with organisms.
Atoms, molecules, organelles, cells, tissues, organ, organ systems, organism
Intracellular
The fluid interior of the cell
Extracellular
The fluid environment outside the enclosure of the cell membrane
Two parts of extracellular
Plasma, interstitial
Plasma
Extracellular matrix
interstitial
Term given to extracellular fluid, not contained within blood vessels
Tissue
A group of many similar cells that work together to perform a specific function
Organ
Anatomically, distinct structure of the body, composed of two or more tissue types
Organ system
A group of organs that work together to perform major functions
Cardiovascular
Delivers oxygen and nutrients to tissues
Equalizes temp body
Respiratory
Removes carbon dioxide from the body
Delivers oxygen to blood
Digestive
Processes food for use by body
Removes waste from digested food
Endocrine
Secrete hormones
Regulates bodily processes
urinary
Controls water balance
Removes waste from body and excrete them
Immune/lymphatic
Return fluid to blood
Defense against pathogens
Integumentary
Encloses internal structures
Site of many sensory receptors
Muscular
Enables movement
Helps maintain body temp
Skeletal
Support body
Enables movement
Nervous
Detect and process of sensory info
Activates bodily responses
Homeostasis
State of steady internal conditions maintained by living things
Define negative feedback loop
A mechanism that reverses, a deviation from a setpoint, maintains body parameters within normal range
Describe an example of a negative feedback in the body, using terms sensor, control center, effector, and response
Setpoint is glucose too high
Sensor: pancreas cells, measure blood glucose
Control center: pancreas cells, release, insulin to bloodstream
Effector: liver cells, respond to insulin by taking in glucose
Blood glucose is reduced
Define positive feedback loop and give specific examples
Intensifies a change in the bodies physiological condition, rather than reversing it
Childbirth: as fetus increases pressure it leads to increased uterus contractions
Explain how gradient and resistance influence the flow of substances
Resistance: membrane prevents salutes from crossing
Gradient: high to low, that determines direction of flow
Gap junction
Intercellular channels that permit, direct cell transfer of ions and small molecules
Tight junctions
Closely associated areas of Z cells whose membranes joined together to form a virtually impermeable barrier to fluid
Anchoring junction
Mechanically attaches a cell to neighboring cells or to the extracellular matrix
Name the four basic tissue types in the human body
Epithelial, connective, muscle, nervous
Describe the general features of epithelial tissues, and give the criteria by which they are classified
Squamous: flattened and thin
Cuboidal: boxy, wide, as it is tall
Columnar: rectangular
Describe the location and structure of the basement membrane.
Deep to the epithelial cells, layer between epithelial and deeper tissue, which is often connective tissue
Simple, squamous, epithelium
Location and function
Location: air sacks of lungs, lining of heart
Function: allows materials to pass through by diffusion and filtration and secretes lubricating substances
Simple, cuboidal, epithelium
Location and function
Location: Kidneys
Function: secrete and absorbs
Simple, columnar, epithelium
Location and function
Location: Digestive tract, Bladder, Uterine tubes
Function: absorbs
Pseudostratified columnar epithelium
Location and function
Location :Trachea
Function: Moves mucus
Stratified squamous epithelium
Location and function
Location: Esophagus, mouth
Function: protects against abrasion
Stratified cuboidal epithelium
Location and function
Location: memory glands, sweat glands
Function: protective tissue
Stratified columnar epithelium
Location and function
Location: male and female urethra
Function: secrets and protects
Transitional epithelium
Location and function
Location: bladder
Function: Allows expansion and stretching
Compare the structure and function of microvilli and cilia
cilia are longer and thicker than microvilli, Cilia can move while microvilli cannot. Cilia our hair like. Microvilli folded membranes.
Describe the general features of connective tissue
Connect tissues and organs, protection, transport fluid, nutrients, waste, chemical messengers
What types of extra cellular material are found in the connective tissue
Matrix and connective tissue
What cells, fiber, and ground substance are in loose, areola, connective tissue?
Cells: fibroblasts, macrophages, mast cells
Fiber: collagen and elastic
Ground substance: gel like
What cells, fibers, ground substance are in adipose connective tissue?
Cells: adipocytes, fat
fiber: none
ground substance: solid
What cells, fibers, ground substance is in reticular connective tissue?
Cells: White blood cells, mast, cells, and macrophages
Fiber: reticular
Ground substance: Typically a loose substance
Cells and fibers, are in dense, irregular connective tissue?
Cells: fibroblasts
Fiber: collagen and a few elastic
What cells and fibers are dense regular connective tissue?
Cells: fibroblasts
fibers: collagen and elastic
What produces the matrix in Hyline cartilage?
Chondroblast
What lies in the lacunae of Hyline cartilage?
chondrocytes
Osteo
Relating to bone
Erythro
Red or reddish
Leuko-
White
Chondro
Cartilage
-blast
Building cell
-cyte
Mature cell
-clast
Break or destructive cell
Why do damage tensions or cartilage heal mite then damage skin, or bone?
Lack of active blood flow
Where are fiber example collagen in connective tissue synthesized?
Through whatever cell type is near the fibroblast
How do fibers get into the extracellular matrix?
Through the ribosomes, modified and packaged in the Golgi apparatus then into transport vesicles into the cell membrane
Describe skeletal muscle tissue
striations, Long, wide, multinucleated
Describe cardiac muscle?
striated, has intercalated discs, different directions
Describe smooth muscle
no striations, long, smooth, spindle shaped
Define intercalated
Lines responsible for connecting the cardiac muscles
What are the three muscle tissues?
Skeletal, cardiac, smooth
Describe the components of nervous tissue?
Cell body of neuron, axons, dendrites,glial cells
Hypertrophy
Increase in cell size
Atrophy
Decrease in size
Hyperplasia
Increase in cell number
Explain why the integumentary system can be classified as a system?
Made of tissues that work together as a single structure to preform functions
What are the functions of the Integumentary system?
Protection, insulation and cushions, prevents water loss, vitamin D synthesis, sensory, excretion and absorption
Identify 5 strata in the epidermis?
Stratum:
corneum
granulosum
spinosum
basale
What type of tissue is the epidermis composed of?
Stratified squamous epithelium
What layer of strata contains melanocytes?
Basale
What layer of strata contains epidermal dendritic cells (Langerhans)?
Spinosum
Function of melanocytes?
A cell that produces melanin
Function of Langerhans cell?
Engulfs bacteria, foreign bacteria and damaged cells
Difference between thin and thick skin?
Thick skin has thinner dermis and doesn’t contain hairs. Thin skin is most the body and thick covers fingertips, palms, soles of feet
What cell junction is found in the epidermis? Their function.
Anchoring- hemidesmosomes, they connect the basale to the basement membrane
Gap- diffusion
Describe the dermis
It is the core of the integumentary system, 2 layers of connective tissues composed of interconnected mesh like elastin and collagen fibers.
What tissues make up papillary of the dermis?
Loose areolar connective tissues
What tissues make up reticular layer of the dermis?
Irregular connective tissues
Describe papillary dermis?
Most superficial dermal region, very uneven, fingerlike projections from its superior surface. Pain and touch receptors are found here.
Describe Reticular dermis ?
Deepest skin layer. Contains many arteries and veins, sweat and sebaceous glands, pressure receptors are found here.
Function of eccrine sweat glands
Maintain homeostasis, stabilized temperature, cool body down
Function of Apocrine sweat glands
Scent glands
Function of Sebaceous gland
Produce an oily matter, called sebum, found in hair follicles
Function of Collagen and elastic fibers
Strength and elasticity
Function of lamellar corpuscles
Sensory receptors for vibration and deep pressure
Function of Tactile corpuscles
Sensitive to fine or light touch
Function of Free nerve endings
Detect, mechanical, stimuli, like touch, pressure, stretch, or danger
Identify the hypodermis and name the tissues that make it up
Layer directly below dermis and serves to connect the skin to fibrous
tissue of bone and muscle
Loose areolar connective, tissue and adipose
Describe how temperature melanin, oxygen saturation and diet contribute to the color of the skin
They cause melanin to be manufactured and built up in keratinocytes, where they secrete chemicals that stimulate melanocytes. Accumulation causes skin to darken.
Identify the location, type of tissue and function of the arrector pili muscles?
Location: dermis
Tissue type: smooth muscle
Function: raise the hair
Explain how the epidermis protects deeper tissues from invading microorganisms
Keratinocytes are first line of innate immune defense
Explain how the epidermis protects deeper tissue from ultraviolet radiation
Melanin
Explain how the epidermis protects deeper tissue from abrasion
corneocytes, strong dead keratinocytes
Explain how epidermis protects deeper tissue from water loss
Keratin synthesizes releases glycolipid
What is about the tissue of the dermis that allows it to resist hearing from pokes and stretches?
Mechanical properties, collagen, and elastin in the thick layer of fibrous and elastic tissue
Describe the response of the integumentary system to an increase in body temperature above normal
Eccrine sweat glands, allow temp control by secretion sweat evaporating thus cooling down the body
Explain how Sweat gland responses help return the body to normal
Thermal regulation is regulated by dilation or construction of heat, carrying blood vessels
Explain the response to decreased body temperatures
Inhibition to excessive sweating, decreases blood flow to the papillary layers
Explain the role of ultraviolet, radiation, and vitamin D production
Energy that stimulates vitamin D production
What organs, modify vitamin D, to make Calcitrol?
Kidneys and liver
Give the function of vitamin D
Increases calcium, absorption, immune boosting effects
Differentiate between first-degree secondary, and third-degree burns by indicating which layers of the skin are involved with each burn type
First-degree, epidermis only, degree, epidermidis and dermis layers, third-degree reaches into all three layers.
As the epidermis heals from an injury, what specific layer of cells replaced damage cells?
stratum basale- keratinocytes mobilize and divide rapidly to repair by collagen forming
What is the name of the cellular reproduction process in replacing damage cells from an injury in the epidermis
Mitosis
How does the dermis heal from an injury?
Red blood cells help create collagen that form a foundation to start filling in with new tissue.
Distinguish between basal cell carcinoma, squamous cell carcinoma, and melanoma, with respect to the cells involved and the seriousness of cancer.
Basale- affects mitotically active stem cells in the Basale, most common
squamous- affects keratinocytes of the spinosum, 2nd most common
melanoma- uncontrolled growth of melanocytes, most fatal
What is metastasis in which type of skin cancer is most likely to metastasize?
Melanoma
What do melanocytes do?
Dictate skin color through the amount of melanin it produces
What do Langerhans cells do?
They since danger and foreign bodies
What gives hair color on the skin?
Melanocytes in the basale layer
Where does squamous cell carcinoma start?
Keratinocytes in the spinosum layer
Where does melanoma start?
In in the melanocytes in the Basale layer
What does basal cell carcinoma affect?
Effects, mitotically, active stem cells
Where does ribosomes make proteins?
In the rough ER
Golgi bodies do what?
Receives protein from rough ER modifies and packages them
What happens to the protein after it’s packaged and transported from the Golgi apparatus?
secreted out of the cell into the basement membrane