1. Naturally acquired active immunity would be most likely acquired through which of the following processes?
   a.vaccination
   b. drinking colostrum
   c. natural birth
   d. infection with disease causing organism followed by recovery.

A

1. Which of the following convey the longest lasting immunity to an infectious agent?
   a.Naturally acquired passive immunity
   b. Artificially acquired passive immunity
   c. Naturally acquired active immunity
   d. All of these
   e. None of these

C

1. B and T cells are produced by stem cells that are formed in:
2. a.Bone marrow
   b. The liver
   c. The circulatory system
   d. The spleen
   e. The lymph nodes

A

1. B cells mature in the……….. while T cells mature in the
   a. Thymus/bone marrow and gut associated lymphoid tissue (GALT)
   b. Spleen/bone marrow and GALT
   c. Bone marrow and GALT/Thymus
   d. Liver/Kidneys

C

1. Which of the following immune cells/molecules are most effective at destroying intracellular pathogens?
   a.T helper cells
   b. B cells
   c. Complement
   d. T cytolytic cells

D

1. A living microbe with reduced virulence that is used for vaccination is considered:
   a.A toxoid
   b. Dormant
   c. Virulent
   d. Attenuated
   e. Denatured

D

1. B cells that produce and release large amounts of antibody are called:
   a.Memory cells
   b. Basophils
   c. Plasma cells
   d. Killer cells
   e. Neutrophils

D

1. The specificity of an antibody is due to
   a.its valence
   b. The heavy chains
   c. The Fc portion of the molecule
   d. The variable portion of the heavy and light chain

D

1. In agglutination reactions, the antigen is a………
   in precipitation reactions, the antigen is a……………
   a.whole cell/soluble molecule
   b. Soluble molecule/whole cell
   c. Bacterium/virus
   d. Protein/carbohydrates
   e. Protein/Antibody

A

1. B Cells are activated by
   a.Complement
   b. Antibody
   c. Interferon
   d. Memory cells
   e. Antigen

E

1. Fusion between a plasma cell and a tumor cell creates a
   a.Myeloma
   b. Natural killer cell
   c. Lymphoblast
   d. Lymphoma
   e. Hybridoma

E

1. Monoclonal antibodies recognize a single:
   a.Antigen
   b. Bacterium
   c. Epitope
   d. B cell
   e. Virus

C

1. Cell mediated immunity is carried out by………….. while humoral immunity is mainly carried out by………………..
   a.B cells/T cells
   b. Epitopes/Antigens
   c. T cells/B cells
   d. Antibodies/Antigens
   e. Antibodies/Phagocytes

The ability of the immune system to recognize self antigens versus nonself antigen is an example of:
a. Specific immunity
b. Tolerance
c. Cell mediated immunity

C

The ability of the immune system to recognize self antigens versus nonself antigen is an example of:

a. Specific immunity
b. Tolerance
c. Cell mediated immunity

d.Antigenic immunity

e.Humoral immunity

B

The b chain of the FceRI:

A Binds IgE.
B Is associated with Lyn.
C Contains a GPI-anchor.
D Possesses an ITIM sequence.

A

Which one of the following mast cell products is not preformed and therefore has to be newly synthesized?:

A Histamine.
B Prostaglandin D₂.
C Heparin.
D Neutral protease.

B

Type I hypersensitivity can be blocked using:

A Histamine.
B An IgA myeloma.
C A myeloma protein of mixed antibody class.
D Sodium cromoglycate.

D

Lol p1-11V are allergens cloned from:

A Rye grass pollen.
B House dust mite.
C House dust mite feces.
D Animal danders.

A

A major unresolved question concerning ADCC is:

A Whether it can be carried out by NK cells.
B Whether it leads to cell death.
C Whether it is complement-dependent.
D To what extent it occurs in vivo.

D

The term reactive lysis usually refers to a sequence of events involving:

A Cytotoxic T-lymphocytes (CTL).
B Antibody-dependent cellular cytotoxicity (ADCC).
C Th1 cells.
D Complement.

D

Maple bark stripper's disease is a hypersensitivity largely affecting the:

A Skin.
B Kidneys.
C Nervous system.
D Lung.

D

Dead Wuchereria bancrofti can cause:

A Elephantiasis.

B Erythema nodosum leprosum.

C Serum sickness.

D Pigeon fancier's disease.

A

Chronic granuloma represents an attempt by the body to:

A Wall off a site of chronic infection.
B Make a site of chronic infection accessible.
C Digest antibody-antigen complexes.
D Initiate an immune response.

A

In thyroid autoimmunity, an antibody causing type V hypersensitivity may be present and is directed against:

A Thyroglobulin.
B Thyroid peroxidase.
C Thyroid stimulating hormone (TSH) receptor.
D Acetylcholine receptor.

C

Which type of hypersensitivity cannot be transferred with serum antibody?:

A Type I.
B Type II.
C Type III.
D Type IV.

D

Anaphylaxis can be triggerred by cross-linking of IgE receptors on:

A Monocytes.
B Mast cells.
C B-cells.
D Eosinophils.

B

Rhesus hemolytic disease of the newborn involves:

A IgE.
B Antibody to cell surfaces.
C Soluble immune complexes.
D Cytokine release from T-cells.

B

The Arthus reaction is characterized by an intense infiltration by:

A Mast cells.
B Neutrophils.
C Eosinophils.
D Macrophages.

B

Type IV hypersentivity is often referred to as:

A Immediate.
B Delayed.
C Anaphylactic.
D Anergic.

B

The injection of tuberculin into the skin of a sensitized individual elicits:

A Immune complex glomerulonephritis.

B Jarisch-Herxheimer reaction.

C Jones-Mote sensitivity.

D Mantoux reaction.

D

The major effector molecules involved in type IV hypersensitivity reactions are:

A Antibodies.
B Complement components.
C Cytokines.
D Prostaglandins.

C

Septic shock associated with Gram-negative bacteria is primarily due to:

A Lipopolysaccharide.
B Enterotoxin superantigen.
C Platelet aggregation.
D Switch off of cytokine release.

A