A woman is found to have 47 chromosomes, including three X chromosomes. Which of the following statements describes her expected phenotype?

healthy female of slightly above-average height

Which of the following statements is generally true of aneuploidies in newborns?

Monosomy X is the only viable monosomy known to occur in humans.

Which of the following correctly describes a Philadelphia chromosome?

a human chromosome 22 that has had a specific translocation

What is a syndrome?

a group of traits typically found in conjunction with a particular chromosomal aberration or gene mutation

A couple has a child with Down syndrome. The mother is 39 years old at the time of delivery. Which of the following is the most probable cause of the child's condition?

One of the gametes in the mother most likely underwent nondisjunction during meiosis.

Abnormal chromosomes are frequently found in malignant tumors. Errors such as translocations may place a gene in close proximity to different control regions. Which of the following events might then occur to make the cancer worse?

expression of inappropriate gene products

A phenotypically normal prospective couple seeks genetic counseling because the man knows that he has a translocation of a portion of his chromosome 4, which has been exchanged with a portion of his chromosome 12. Although his translocation is balanced, he and his wife want to know the probability that his sperm will be abnormal. What is your prognosis regarding his sperm?

One-quarter will carry the two normal chromosomes, 4 and 12, one-quarter will have only the two translocation chromosomes and no normal chromosomes 4 and 12, and half will have one normal and one translocated chromosome.

Of the following human aneuploidies, which is the one that generally has the most severe impact on the health of the individual?

47, trisomy 21

Which of the following statements correctly describes what happens to a chromosome after a nonreciprocal translocation occurs?

A chromosome transfers a fragment but receives none in return.

One possible result of chromosomal breakage is for a fragment to join a nonhomologous chromosome. What is this type of chromosomal alteration called?

translocation

If cell X enters meiosis, and nondisjunction of one chromosome occurs in one of its daughter cells during meiosis II, how will this affect the gametes at the completion of meiosis?

One-quarter of the gametes descended from cell X will be n + 1, one-quarter will be n - 1, and half will be n.

In Drosophila melanogaster, vestigial wings are determined by a recessive allele of a gene that is linked to a gene with a recessive allele that determines black body color. T. H. Morgan crossed black-bodied, normal-winged females and gray-bodied, vestigial-winged males. The F1 were all gray bodied, normal winged. The F1 females were crossed to homozygous recessive males to produce testcross progeny. Morgan calculated the map distance to be 17 map units. Which of the following information is correct about the testcross progeny?

gray-bodied, normal-winged flies plus black-bodied, vestigial-winged flies = 17% of the total

A homozygous tomato plant with red fruit and yellow flowers was crossed with a homozygous tomato plant with golden fruit and white flowers. The F1 all had red fruit and yellow flowers. The F1 were testcrossed by crossing them to homozygous recessive individuals, and the following offspring were obtained:

Red fruit and yellow flowers—41
Red fruit and white flowers—7
Golden fruit and yellow flowers—8
Golden fruit and white flowers—44

How many map units separate these genes?

15

Which of the following statements correctly describes the reason that closely linked genes are typically inherited together?

They are located close together on the same chromosome.

Use the following information to answer the question.

A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine.

A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type):

The greatest distance among the three genes is between a and c. What does this mean?

Genes are in the order: a-b-c.

Use the following information to answer the question.

A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine.

A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type):

What is the greatest benefit of having used a testcross for this experiment?

The phenotypes of the progeny reveal the allelic content of the gamete from the heterozygous parent.

Use the following information to answer the question.

A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine.

A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type):

If recombination frequency is equal to distance in map units, what is the approximate distance between genes A and B?

3 map units

Use the following information to answer the question.

A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine.

A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type):

Which of the progeny phenotypes will require recombination between genes A and B?

1, 2, 5, and 6

Use the following information to answer the question.

A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves, due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots due to an allele (c) of gene C. The three genes are linked and recombine.

A geneticist performed a testcross with an organism that had been found to be heterozygous for the three recessive traits, and she was able to identify progeny of the following phenotypic distribution (+ = wild type):

Which of the following are the phenotypes of the parents in this cross?

4 and 8

Use the following information to answer the question.

In a series of mapping experiments, the recombination frequencies for four different linked genes of Drosophila were determined as shown in the figure. Based on this information, what is the order of these genes on a chromosome map?

b-rb-cn-vg

Use the following map of four genes on a chromosome to answer the question.

Between which two genes would you expect the highest frequency of recombination?

A and G

Map units on a linkage map cannot be relied upon to calculate physical distances on a chromosome for which of the following reasons?

The frequency of crossing over varies along the length of the chromosome.

What is an adaptive advantage of recombination between linked genes?

New allele combinations are acted upon by natural selection.

Which of the following occurrences describes how recombination between linked genes comes about?

Crossovers between these genes result in chromosomal exchange.

Which of the following phrases correctly defines what one map unit is?

a 1% frequency of recombination between two genes

What does a recombination frequency of 50% indicate?

The two genes are likely to be located on different chromosomes.

Which of the following statements would explain a testcross involving F1 dihybrid flies in which more parental-type offspring than recombinant-type offspring are produced?

The two genes are closely linked on the same chromosome.

Which of the following statements regarding gene linkage is correct?

The closer two genes are on a chromosome, the lower the probability that a crossover will occur between them.

Use the following information to answer the question.

In a Drosophila experiment, a cross was made between homozygous wild-type females and yellow-bodied males. All of the resulting F1s were phenotypically wild type. However, adult flies of the F2 generation (resulting from matings of the F1s) had the characteristics shown in the figure. How is the mutant allele for yellow body inherited?

It is X-linked.

Use the following information to answer the question.

In a Drosophila experiment, a cross was made between homozygous wild-type females and yellow-bodied males. All of the resulting F1s were phenotypically wild type. However, adult flies of the F2 generation (resulting from matings of the F1s) had the characteristics shown in the figure. How is the mutant allele for yellow body inherited?

It is recessive.

Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked recessive allele in humans. A woman whose father suffered from G6PD marries a man who has the disease. What proportion of their sons would have the disease?

1/2

Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as an X-linked recessive allele in humans. A woman whose father suffered from G6PD marries a normal man. What proportion of their sons is expected to be G6PD?

1/2

Which of the following individuals will inherit an X-linked allele from a man who carries it?

all of his daughters

A recessive allele on the X chromosome is responsible for red-green color blindness in humans. A woman with normal vision whose father is color blind marries a color-blind male. What is the probability that this couple's first son will be color blind?

1/2

Pseudohypertrophic muscular dystrophy is a human disorder that causes gradual deterioration of the muscles. Only boys are affected, and they are always born to phenotypically normal parents. Due to the severity of the disease, the boys die in their teens. Is this disorder likely to be caused by a dominant or recessive allele? Is the inheritance of this trait sex-linked or autosomal?

recessive, sex-linked

A man who is a dwarf with achondroplasia and normal vision marries a color-blind woman of normal height. The man's father was six feet tall, and both the woman's parents were of average height. Dwarfism caused by achondroplasia is autosomal dominant, and red-green color blindness is X-linked recessive. What proportion of their sons would be color blind and of normal height?

half

A man who is a dwarf with achondroplasia and normal vision marries a color-blind woman of normal height. The man's father was six feet tall, and both the woman's parents were of average height. Dwarfism caused by achondroplasia is autosomal dominant, and red-green color blindness is X-linked recessive. How many of their daughters might be expected to be color-blind with achondroplasia?

none

All female mammals have one active X chromosome per cell instead of two. What causes this to happen?

activation of the XIST gene on the X chromosome that will become the Barr body

Duchenne muscular dystrophy is a serious condition caused by a recessive allele of a gene on the human X chromosome. The patients have muscles that weaken over time because they have absent or decreased dystrophin, a muscle protein. They rarely live past their 20s. How likely is it for a woman to have this condition?

One-half of the daughters of an affected father and a carrier mother could have this condition.

In humans, clear gender differentiation occurs not at fertilization, but after the second month of gestation. Which of the following statements describes the first event of this differentiation?

activation of SRY in male embryos and masculinization of the gonads

Sex determination in mammals is due to the SRY gene found on the Y chromosome. Which of the following situations could allow a person with an XX karyotype to develop a male phenotype?

translocation of SRY to an X chromosome

In birds, sex is determined by a ZW chromosome scheme. Males are ZZ and females are ZW. A recessive lethal allele that causes death of the embryo is sometimes present on the Z chromosome in pigeons. What would be the sex ratio in the offspring of a cross between a male that is heterozygous for the lethal allele and a normal female?

2:1 male to female

Generally, only female cats have the tortoiseshell phenotype for fur color. Which of the following statements explains this phenomenon?

A male inherits only one allele of the X-linked gene controlling hair color.

Cinnabar eye color is a sex-linked, recessive characteristic in fruit flies. If a female having cinnabar eyes is crossed with a wild-type male, what percentage of the F1 males will have cinnabar eyes?

100%

Red-green color blindness is a sex-linked recessive trait in humans. Two people with normal color vision have a color-blind son. What are the genotypes of the parents?

XNXn and XNY

In cats, black fur color is determined by an X-linked allele; the other allele at this locus determines orange color. The heterozygote is tortoiseshell. What kinds of offspring would you expect from the cross of a black female and an orange male?

tortoiseshell females; black males

The SRY gene is best described as ________.

a gene present on the Y chromosome that triggers male development

Why are males more often affected by sex-linked traits than females?

Males are hemizygous for the X chromosome.

Which of the following statements correctly describes the meaning of the chromosome theory of inheritance as expressed in the early 20th century?

Mendelian genes are at specific loci on the chromosome and, in turn, segregate during meiosis.

When Thomas Hunt Morgan crossed his red-eyed F1 generation flies to each other, the F2 generation included both red- and white-eyed flies. Remarkably, all the white-eyed flies were male. What was the explanation for this result?

The gene involved is located on the X chromosome.