Which one of the following microbes would have the best chance of being an effective Jennerian vaccine for COVID-19 (caused by SARS-CoV2)?

a.A feline coronavirus that causes mild GI tract infections in cats.

b.A human coronavirus that causes mild respiratory tract infections in humans.

c.A bacteria that causes subclinical respiratory tract infections in chimpanzees.

d.A fungus that causes severe respiratory tract infections in gorillas.eA bacteria that causes sever respiratory tract infections in humans.

a.A feline coronavirus that causes mild GI tract infections in cats.

True/False: Individuals that receive a vector-based vaccine, like the J&J COVID vaccine just discussed, make immune responses (B and T cell responses) to vector antigens (adenovirus proteins).

A.) True

B.) False

True

Question #3UnansweredWhich one of the following types of antibodies induced by the vector-based rabies vaccine will not provide protection against rabies virus infection/disease. Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer.aAntibodies that neutralize rabies virus infectivity.bAntibodies that activate the classic complement cascade.cAntibodies that function as opsonins.dAntibodies that participate in ADCC (kill virus-infected cells).eAntibodies that are secreted onto mucosal surfaces (sIgA).

e. Antibodies that are secreted onto mucosal surfaces (sIgA).

Which one of the following statements about the practice of vaccination is false?

a.An individual's MHC alleles can influence the quality/magnitude of their adaptive immune response to vaccine antigens.

b.Vaccination stimulates the production of effector B and effector T lymphocytes.

c.Vaccines stimulate cells of the adaptive immune system but they do not stimulate cells of the innate immune system.

d.Vaccination is typically used to prevent disease instead of to treat disease.

e.Vaccination induces immunologic memory.

c.Vaccines stimulate cells of the adaptive immune system but they do not stimulate cells of the innate immune system.

True/False: The immune response made to the smallpox vaccine (vaccinia virus) is more likely to occur in lymph nodes than in the Peyer's patches.

True

Which one of the following statements about smallpox vaccination using vaccinia virus is false?

a.Some of the cells that are infected following administration of the smallpox vaccine (vaccinia virus) will be killed by NK cells.

b.The smallpox vaccine is an example of an attenuated live virus vaccine.

c.Some of the antibodies induced by the smallpox vaccine will be capable of neutralizing vaccinia virus and variola virus (the smallpox virus).

d.Some of the antibodies induced by the smallpox vaccine will be capable of killing vaccinia virus-infected cells through the mechanism of ADCC.

e.Vaccinia virus induces the expression of B7 on some APCs.

The smallpox vaccine is an example of an attenuated live virus vaccine.

The attenuated-live poliovirus vaccine (OPV) replicates in the gut and is shed in the feces (fact). True/False: If an unvaccinated individual gets infected with the virus that is shed from a vaccinated individual then they will most likely become immune to poliovirus.

True

Which one of the following statements about a live-attenuated virus vaccine is false?

a.This type of vaccine does not infect or kill cells in the individual that receives the vaccine.

b.This type of vaccine can acquire genetic mutations after being administered to an individual.

c.This type of vaccine can revert to a disease causing form.

d.This type of vaccine helped to eradicate polio virus from the USA.

e.This type of vaccine is recognized by PAMP-receptors by some cells of the person that receives the vaccine.

a.This type of vaccine does not infect or kill cells in the individual that receives the vaccine.

Which one of the following polio vaccines does a better job of inducing the production of antibodies capable of being bound by the poly-Ig receptor?

a. OPV

b. IPV

a. OPV

Which one of the following polio vaccines does a better job of inducing the production of CTLs.

a. OPV

b. IPV

b. OPV

In one of our very first lectures you learned about a PAMP receptor called cGAS that detects DNA in the cytoplasm of a cell. cGAS would be expected to recognize/bind to a DNA-based vaccine after it is internalized by a cell. If this did occur, do you think this would enhance the immune response to the vaccine, or decrease the immune response to the vaccine?

a.Increase the immune response to the vaccine.

b.Decrease the immune response to the vaccine.

a.Increase the immune response to the vaccine.

Which one of the following vaccine types would be most likely to cause disease in an immunodeficient individual?

a.A Jennerian vaccine consisting of a live virus that naturally infects goats.

b.A DNA vaccine.

c.A toxoid vaccine.

d.A formalin-killed vaccine.

e.The Gardasil VLP-based HPV vaccine.

a.A Jennerian vaccine consisting of a live virus that naturally infects goats.