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Medical/Trauma Meds Drug Interactions

1.

Dextrose (D50, D25, D10)

Drug Interactions:

  • Sodium bicarbonate
  • Coumadin
2.

Diazepam (Valium)

Drug Interactions:

  • Clozapine
  • Fluvoxamine
  • Orlistat
  • Sodium oxybate
3.

Diphenhydramine hydrochloride (Benadryl)

Drug Interactions:

  • Potentates' effects of alcohol and other anticholinergics.
  • May inhibit corticosteroid activity.
4.

Epinephrine (1:1000, 1:10,000)

Drug Interactions:

  • Potentates other sympathomimetics.
  • Deactivated by alkaline solutions.
  • MAOIs may potentate effects of epinephrine.
5.

Fentanyl citrate (Sublimaze)

Drug Interactions:

 Many Rx interactions use with caution in conjunction with other opioid, narcotic, or CNS depressant medications.

6.

Glucagon

Drug Interactions:

  • Incompatible in solution with most other substances.
  • No significant drug interactions with other emergency medications.
7.

Hydrocortisone sodium succinate (Cortef, Solu-Cortef)

Drug Interactions:

  • Calcium
8.

Hydroxocobalamin (Vitamin B 12)
*cyano-kit

Drug Interactions

No formal drug interaction studies have been conducted.

9.

Ketamine (Ketalar)

Drug Interactions:
Increases the effects of

  • Opiates
  • Barbiturates
  • Nondepolarizing neuromuscular blockers
10.

Lorazepam (Ativan)

Drug Interactions:
 May precipitate CNS depression if patient is already taking CNS depressant medications.

  • Benzodiazepines
    diazepam (Valium®)
    clonazepam (Klonopin®)
    alprazolam (Xanax®)
    triazolam (Halcion®)
    estazolam (Prosom®)
  • Non-Benzodiazepine Sedative Hypnotics
    zolpidem (Ambien®)
    eszopiclone (Lunesta®)
    zaleplon (Sonata®)
  • Barbiturates
    mephobarbital (Mebaral®)
    phenobarbital (Luminal®)
    pentobarbital sodium (Nembutal®)
11.

Methylprednisolone sodium succinate (Solu-Medrol)

Drug Interactions:

  • Calcium
12.

Midazolam (Versed)

Drug Interactions:
 Should not be used in patients who have taken CNS depressants.

  • Benzodiazepines
    diazepam (Valium®)
    clonazepam (Klonopin®)
    alprazolam (Xanax®)
    triazolam (Halcion®)
    estazolam (Prosom®)
  • Non-Benzodiazepine Sedative Hypnotics
    zolpidem (Ambien®)
    eszopiclone (Lunesta®)
    zaleplon (Sonata®)
  • Barbiturates
    mephobarbital (Mebaral®)
    phenobarbital (Luminal®)
    pentobarbital sodium (Nembutal®)
13.

Naloxone (Narcan)

Drug Interactions:

None known.

14.

Ondansetron (Zofran)

Drug Interactions:

  • Apomorphine
  • Tramadol
15.

Pralidoxime chloride (2-PAM, Protopam)

Drug Interactions:

No direct drug interactions, however, patients with organophosphate poisoning should not be given:

  • Barbiturates
  • Morphine
  • Theophylline
  • Aminophylline
  • Succinylcholine
  • Reserpine
  • Phenothiazines
16.

Tranexamic acid (TXA)

Drug Interactions:

  • Hormonal contraceptives