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Micro 2117 Chapter 14-19

front 1

A commensal bacterium

  1. does not receive any benefit from its host.
  2. is beneficial to its host.
  3. may also be an opportunistic pathogen.
  4. isn't capable of causing disease in its host.
  5. always causes disease in its host.

back 1

C) may also be an opportunistic pathogen.

front 2

Which of the following statements is TRUE?

A) Both members are harmed in a symbiotic relationship.

B) Members of a symbiotic relationship cannot live without each other.

C) A parasite is not in symbiosis with its host.

D) Symbiosis always refers to different organisms living together and benefiting from each other.

E) At least one member must benefit in a symbiotic relationship.

back 2

E) At least one member must benefit in a symbiotic relationship.

front 3

A nosocomial infection is

A) always present, but is inapparent at the time of hospitalization.

B) acquired during the course of hospitalization.

C) always caused by medical personnel.

D) only a result of surgery.

E) always caused by pathogenic bacteria.

back 3

B) acquired during the course of hospitalization.

front 4

The major significance of Robert Koch's work is that

A) microorganisms are present in a diseased animal.

B) diseases can be transmitted from one animal to another.

C) microorganisms can be cultured.

D) microorganisms cause disease.

E) microorganisms are the result of disease.

back 4

D) microorganisms cause disease.

front 5

Which of the following is NOT a verified exception in the use of Koch's postulates?

A) Some diseases have poorly defined etiologies.

B) Some pathogens can cause several disease conditions.

C) Some human diseases have no other known animal host.

D) Some diseases are not caused by microbes.

E) Some diseases are noncommunicable.

back 5

E) Some diseases are noncommunicable.

front 6

Which of the following diseases is NOT spread by droplet infection?

A) botulism

B) tuberculosis

C) measles

D) the common cold

E) diphtheria

back 6

A) botulism

front 7

Biological transmission differs from mechanical transmission in that biological transmission

A) occurs when a pathogen is carried on the feet of an insect.

B) involves fomites.

C) involves reproduction of a pathogen in an arthropod vector prior to transmission.

D) requires direct contact.

E) works only with noncommunicable diseases.

back 7

C) involves reproduction of a pathogen in an arthropod vector prior to transmission.

front 8

Which of the following definitions is INCORRECT?

A) endemic: a disease that is constantly present in a population

B) epidemic: a disease that is endemic across the world

C) pandemic: a disease that affects a large number of people in the world in a short time

D) sporadic: a disease that affects a population occasionally

E) incidence: number of new cases of a disease

back 8

B) epidemic: a disease that is endemic across the world

front 9

Focal infections initially start out as

A) sepsis.

B) bacteremia.

C) local infections.

D) septicemia.

E) systemic infections.

back 9

C) local infections.

front 10

The rise in herd immunity amongst a population can be directly attributed to

A) increased use of antibiotics.

B) improved handwashing.

C) vaccinations.

D) antibiotic-resistant microorganisms.

E) None of the answers is correct.

back 10

C) vaccinations.

front 11

Koch observed Bacillus anthracis multiplying in the blood of cattle. What is this condition called?

A) bacteremia

B) focal infection

C) local infection

D) septicemia

E) systemic infection

back 11

C) local infection

front 12

Which one of the following does NOT contribute to the incidence of nosocomial infections?

A) antibiotic resistance

B) lapse in aseptic techniques

C) gram-negative cell walls

D) lack of handwashing

E) lack of insect control

back 12

C) gram-negative cell walls

front 13

Transient microbiota differ from normal microbiota in that transient microbiota

A) cause diseases.

B) are found in a certain location on the host.

C) are always acquired by direct contact.

D) are present for a relatively short time.

E) never cause disease.

back 13

D) are present for a relatively short time.

front 14

Which of the following statements about nosocomial infections is FALSE?

A) They occur in compromised patients.

B) They may be caused by opportunists.

C) They may be caused by drug-resistant bacteria.

D) They may be caused by normal microbiota.

E) The patient was infected before hospitalization.

back 14

E) The patient was infected before hospitalization.

front 15

One effect of washing regularly with antibacterial agents is the removal of normal microbiota. This can result in

A) body odor.

B) fewer diseases.

C) increased susceptibility to disease.

D) normal microbiota returning immediately.

E) no bacterial growth because washing removes their food source.

back 15

D) normal microbiota returning immediately.

front 16

Which of the following is NOT a reservoir of infection?

A) a sick person

B) a healthy person

C) a sick animal

D) a hospital

E) None of the answers is correct; all of these can be reservoirs of infection.

back 16

E) None of the answers is correct; all of these can be reservoirs of infection.

front 17

Which of the following is NOT a communicable disease?

A) malaria

B) AIDS

C) tuberculosis

D) tetanus

E) typhoid fever

back 17

D) tetanus

front 18

Which of the following is a fomite?

A) water

B) droplets from a sneeze

C) pus

D) insects

E) a hypodermic needle

back 18

E) a hypodermic needle

front 19

Which of the following statements about biological transmission is FALSE?

A) The pathogen reproduces in the vector.

B) The pathogen may enter the host in the vector's feces.

C) Houseflies are an important vector.

D) The pathogen may be injected by the bite of the vector.

E) The pathogen may require the vector as a host.

back 19

C) Houseflies are an important vector.

front 20

Which of the following definitions is INCORRECT?

A) acute: a short-lasting primary infection

B) inapparent: infection characteristic of a carrier state

C) chronic: a disease that develops slowly and lasts for months

D) primary infection: an initial illness

E) secondary infection: a long-lasting illness

back 20

E) secondary infection: a long-lasting illness

front 21

Symptoms of disease differ from signs of disease in that symptoms

A) are changes felt by the patient.

B) are changes observed by the physician.

C) are specific for a particular disease.

D) always occur as part of a syndrome.

E) None of the answers is correct.

back 21

A) are changes felt by the patient.

front 22

The science that deals with when diseases occur and how they are transmitted is called

A) ecology.

B) epidemiology.

C) communicable disease.

D) morbidity and mortality.

E) public health.

back 22

B) epidemiology.

front 23

Figure 14.1 shows the incidence of influenza during a typical year. Which letter on the graph indicates the endemic level?

A) a

B) b

C) c

D) d

E) The answer cannot be determined based on the information provided.

back 23

D) d

front 24

Emergence of infectious diseases can be attributed to all of the following EXCEPT

A) antibiotic resistance.

B) climatic changes.

C) new strains of previously known agents.

D) ease of travel.

E) The emergence of infectious diseases can be attributed to all of these.

back 24

E) The emergence of infectious diseases can be attributed to all of these.

front 25

Which of the following pairs is mismatched?

A) malaria — vector

B) salmonellosis — vehicle transmission

C) syphilis — direct contact

D) influenza — droplet infection

E) None of the pairs is mismatched.

back 25

E) None of the pairs is mismatched.

front 26

Which of the following can contribute to postoperative infections?

A) using syringes more than once

B) normal microbiota on the operating room staff

C) errors in aseptic technique

D) antibiotic resistance

E) All of the answers are correct.

back 26

E) All of the answers are correct.

front 27

In Figure 14.2, when is the prevalence the highest?

A) July

B) January

C) February

D) March

E) The answer cannot be determined based on the information provided.

back 27

C) February

front 28

A cold transmitted by a facial tissue is an example of

A) direct contact.

B) droplet transmission.

C) fomite.

D) vector.

E) vehicle transmission.

back 28

E) vehicle transmission.

front 29

A researcher has performed a prospective study on a disease. To which specific kind of epidemiological study is this referring?

A) analytical

B) case control

C) descriptive

D) experimental

E) prodromal

back 29

C) descriptive

front 30

The CDC is located in

A) Atlanta, GA.

B) Washington, DC.

C) New York City, NY.

D) Los Angeles, CA.

E) Chicago, IL.

back 30

A) Atlanta, GA.

front 31

A disease in which the causative agent remains inactive for a time before producing symptoms is referred to as

A) subacute.

B) subclinical.

C) latent.

D) zoonotic.

E) acute.

back 31

C) latent.

front 32

A needlestick is an example of

A) direct contact.

B) droplet transmission.

C) indirect contact transmission by fomite.

D) direct biological transmission by vector.

E) vehicle transmission.

back 32

C) indirect contact transmission by fomite.

front 33

Which of the following is NOT a predisposing factor of disease?

A) lifestyle

B) genetic background

C) climate

D) occupation

E) All of these are predisposing factors of disease.

back 33

E) All of these are predisposing factors of disease.

front 34

In which of the following diseases can gender be considered a viable predisposing factor?

A) urinary tract infections

B) pneumonia

C) salmonellosis

D) tetanus

E) anthrax

back 34

A) urinary tract infections

front 35

In which of the following patterns of disease does the patient experience no signs or symptoms?

A) prodromal

B) decline

C) convalescence

D) incubation

E) both incubation and convalescence

back 35

E) both incubation and convalescence

front 36

Situation 14.1

During a six-month period, 239 cases of pneumonia occurred in a town of 300 people. A clinical case was defined as fever ≥ 39°C lasting >2 days with three or more symptoms (i.e., chills, sweats, severe headache, cough, aching muscles/joints, fatigue, or feeling ill). A laboratory-confirmed case was defined as a positive result for antibodies against Coxiella burnetii. Before the outbreak, 2000 sheep were kept northwest of the town. Of the 20 sheep tested from the flock, 15 were positive for C. burnetii antibodies. Wind blew from the northwest, and rainfall was 0.5 cm compared with 7 to 10 cm during each of the previous three years.

36) Situation 14.1 is an example of

A) human reservoirs.

B) a zoonosis.

C) a nonliving reservoir.

D) a vector.

E) a focal infection.

back 36

B) a zoonosis.

front 37

The etiologic agent of the disease in Situation 14.1 is

A) sheep.

B) soil.

C) Coxiella burnetii.

D) pneumonia.

E) wind.

back 37

C) Coxiella burnetii.

front 38

The method of transmission of the disease in Situation 14.1 was

A) direct contact.

B) droplet.

C) indirect contact.

D) vector-borne.

E) vehicle.

back 38

E) vehicle.

front 39

Which of the following is NOT an example of microbial antagonism?

A) acid production by bacteria

B) bacteriocin production

C) bacteria occupying host receptors

D) bacteria causing disease

E) bacteria producing vitamin K

back 39

D) bacteria causing disease

front 40

The yeast Candida albicans does not normally cause disease because of

A) symbiotic bacteria.

B) antagonistic bacteria.

C) parasitic bacteria.

D) commensal bacteria.

E) other fungi.

back 40

B) antagonistic bacteria.

front 41

If a prodromal period exists for a certain disease, it should occur prior to

A) incubation.

B) illness.

C) decline.

D) convalescence.

back 41

B) illness.

front 42

Which one of the following is NOT a zoonosis?

A) cat-scratch disease

B) Hantavirus pulmonary syndrome

C) rabies

D) tapeworm

E) All of these are zoonoses.

back 42

E) All of these are zoonoses.

front 43

Pseudomonas bacteria colonized the bile duct of a patient following his liver transplant surgery. This is an example of a

A) communicable disease.

B) latent infection.

C) nosocomial infection.

D) sporadic disease.

E) None of the answers is correct.

back 43

C) nosocomial infection.

front 44

The graph in Figure 14.3 shows the incidence of polio in the United States. The period between 1945 and 1955 indicates a(n)

A) endemic level.

B) epidemic level.

C) sporadic infection.

D) communicable disease.

E) pandemic.

back 44

B) epidemic level.

front 45

Which of the following statements is FALSE?

A) Antimicrobial therapy for hemodialysis-associated infections increases antibiotic resistance.

B) aureus is differentiated from other mannitol+ cocci by the coagulase test.

C) The M in MRSA stands for mannitol.

D) The USA100 strain accounts for most hospital-acquired MRSA.

E) The USA300 strain accounts for most community-acquired MRSA.

back 45

C) The M in MRSA stands for mannitol.

front 46

For a particular disease at a specific time period, morbidity rates should always be equal or greater than mortality rates.

True/False

back 46

Answer: TRUE

front 47

Testing the effectiveness of a new drug for anthrax would be best performed as an experimental study.

True/False

back 47

Answer: TRUE

front 48

MMWR is a publication by the CDC that reports on only emerging diseases.

True/False

back 48

Answer: FALSE

front 49

A researcher only needs to select a cohort group when implementing an analytical epidemiological study.

True/False

back 49

Answer: FALSE

front 50

Diseases that are referred to as emerging infectious diseases have only been discovered in the past fifty years.

True/False

back 50

Answer: FALSE

front 51

Compromised hosts are always suffering from suppressed immune systems.

True/False

back 51

Answer: FALSE

front 52

A host is not considered diseased until an infection changes one's state of health.

True/False

back 52

Answer: TRUE

front 53

Reservoirs of infections are always animate objects.

True/False

back 53

Answer: FALSE

front 54

Urinary tract infections are the most common forms of nosocomial infections.

True/False

back 54

Answer: FALSE

front 55

Both normal and transient flora can become opportunistic pathogens.

True/False

back 55

Answer: TRUE

front 56

The most frequently used portal of entry for pathogens is the

A) mucous membranes of the respiratory tract.

B) mucous membranes of the gastrointestinal tract.

C) skin.

D) parenteral route.

E) All of these portals are used equally.

back 56

A) mucous membranes of the respiratory tract.

front 57

The ability of some microbes, such as Trypanosoma or Giardia to alter their surface molecules and evade destruction by the host's antibodies is called

A) antigenic variation.

B) lysogenic conversion.

C) virulence.

D) cytopathic effect.

E) cytocidal effect.

back 57

A) antigenic variation.

front 58

Most pathogens that gain access through the skin

A) can penetrate intact skin.

B) just infect the skin itself.

C) enter through hair follicles and sweat ducts.

D) must adhere first while their invasive factors allow them to penetrate.

E) must be injected.

back 58

C) enter through hair follicles and sweat ducts.

front 59

The ID50 is

A) a measure of pathogenicity.

B) the dose that will cause an infection in 50 percent of the test population.

C) the dose that will kill some of the test population.

D) the dose that will cause an infection in some of the test population.

E) the dose that will kill 50 percent of the test population.

back 59

B) the dose that will cause an infection in 50 percent of the test population.

front 60

All of the following contribute to a pathogen's invasiveness EXCEPT

A) toxins.

B) capsules.

C) cell wall components.

D) hyaluronidase.

E) coagulases.

back 60

A) toxins.

front 61

Which of the following statements is FALSE?

A) Leukocidins destroy neutrophils.

B) Hemolysins lyse red blood cells.

C) Hyaluronidase breaks down substances between cells.

D) Kinase destroys fibrin clots.

E) Coagulase destroys blood clots.

back 61

E) Coagulase destroys blood clots.

front 62

Which of the following statements about exotoxins is generally FALSE?

A) They are more potent than endotoxins.

B) They are composed of proteins.

C) They are resistant to heat.

D) They have specific methods of action.

E) They are produced by gram-positive bacteria.

back 62

C) They are resistant to heat.

front 63

Endotoxins are

A) associated with gram-positive bacteria.

B) molecules that bind nerve cells.

C) part of the gram-negative cell wall.

D) excreted from the cell.

E) A-B toxins.

back 63

C) part of the gram-negative cell wall.

front 64

Which of the following is NOT a membrane-disrupting toxin?

A) A-B toxin

B) hemolysin

C) leukocidin

D) streptolysin O

E) streptolysin S

back 64

A) A-B toxin

front 65

Cytopathic effects are changes in host cells due to

A) viral infections.

B) protozoan infections.

C) fungal infections.

D) bacterial infections.

E) helminthic infections.

back 65

A) viral infections.

front 66

Which of the following does NOT contribute to the symptoms of a fungal disease?

A) capsules

B) toxins

C) allergic response of the host

D) cell walls

E) metabolic products

back 66

D) cell walls

front 67

All of the following are methods of avoiding host antibodies EXCEPT

A) antigenic changes.

B) IgA proteases.

C) invasins.

D) membrane-disrupting toxins.

E) inducing endocytosis.

back 67

D) membrane-disrupting toxins.

front 68

Siderophores are bacterial proteins that compete with the host's

A) antibodies.

B) red blood cells.

C) iron-transport proteins.

D) white blood cells.

E) receptors.

back 68

C) iron-transport proteins.

front 69

The fimbriae of Neisseria gonorrhea and enteropathogenic E. coli are examples of

A) adhesins.

B) ligands.

C) receptors.

D) adhesins and ligands.

E) adhesins, ligands, and receptors.

back 69

D) adhesins and ligands.

front 70

All of the following are examples of entry via the parenteral route EXCEPT

A) injection.

B) bite.

C) surgery.

D) hair follicle.

E) skin cut.

back 70

D) hair follicle.

front 71

Superantigens produce intense immune responses by stimulating lymphocytes to produce

A) endotoxins.

B) exotoxins.

C) cytokines.

D) leukocidins.

E) interferons.

back 71

C) cytokines.

front 72

Botulism is caused by ingestion of a proteinaceous exotoxin; therefore, it can easily be prevented by

A) boiling food prior to consumption.

B) administering antibiotics to patients.

C) not eating canned food.

D) preventing fecal contamination of food.

E) filtering food.

back 72

A) boiling food prior to consumption.

front 73

All of the following organisms produce exotoxins EXCEPT

A) Salmonella typhi.

B) Clostridium botulinum.

C) Corynebacterium diphtheriae.

D) Clostridium tetani.

E) Staphylococcus aureus.

back 73

A) Salmonella typhi.

front 74

Which of the following cytopathic effects is cytocidal?

A) inclusion bodies

B) giant cells

C) antigenic changes

D) transformation

E) release of enzymes from lysosomes

back 74

E) release of enzymes from lysosomes

front 75

All of the following are used by bacteria to attach to host cells EXCEPT

A) M protein.

B) ligands.

C) fimbriae.

D) capsules.

E) A-B toxins.

back 75

E) A-B toxins.

front 76

Symptoms of protozoan and helminthic diseases are due to

A) tissue damage due to growth of the parasite on the tissues.

B) waste products excreted by the parasite.

C) products released from damaged tissues.

D) tissue damage due to growth of the parasite on the tissues and waste products excreted by the parasite.

E) tissue damage due to growth of the parasite on the tissues, waste products excreted by the parasite, and products released from damaged tissues.

back 76

E) tissue damage due to growth of the parasite on the tissues, waste products excreted by the parasite, and products released from damaged tissues.

front 77

Which of the following statements about staphylococcal enterotoxin is FALSE?

A) It causes vomiting.

B) It causes diarrhea.

C) It is an exotoxin.

D) It is produced by Staphylococcus aureus growing in the host's intestines.

E) It is a superantigen.

back 77

D) It is produced by Staphylococcus aureus growing in the host's intestines.

front 78

Which of the following contributes to the virulence of a pathogen?

A) numbers of microorganisms that gain access to a host

B) evasion of host defenses

C) toxin production

D) numbers of microorganisms that gain access to a host and evasion of host defenses

E) numbers of microorganisms that gain access to a host, evasion of host defenses, and toxin production

back 78

E) numbers of microorganisms that gain access to a host, evasion of host defenses, and toxin production

front 79

Lysogenic bacteriophages contribute to bacterial virulence because bacteriophages

A) give new gene sequences to the host bacteria.

B) produce toxins.

C) carry plasmids.

D) kill the bacteria, causing release of endotoxins.

E) kill human cells.

back 79

A) give new gene sequences to the host bacteria.

front 80

Twenty-five people developed symptoms of nausea, vomiting, and diarrhea three to six hours after attending a church picnic where they ate a ham and green bean casserole with cream sauce. The most likely cause of this case of food intoxication is

A) botulinum toxin.

B) aflatoxin.

C) staphylococcal enterotoxin.

D) erythrogenic toxin.

E) cholera toxin.

back 80

D) erythrogenic toxin.

front 81

Which of the following statements about M protein is FALSE?

A) It is found on Streptococcus pyogenes.

B) It is found on fimbriae.

C) It is heat- and acid-resistant.

D) It is readily digested by phagocytes.

E) It is a protein.

back 81

D) It is readily digested by phagocytes.

front 82

Symptoms of intense inflammation and shock occur in some gram-positive bacterial infections due to

A) A-B toxins.

B) lipid A.

C) membrane-disrupting toxins.

D) superantigens.

E) erythrogenic toxin.

back 82

D) superantigens.

front 83

Which of the following is an example of direct damage due to bacterial infection?

A) the uncontrolled muscle contractions in Clostridium tetani infection

B) the invasion and lysis of intestinal cells by coli

C) the hemolysis of red blood cells in a staphylococcal infection

D) the fever, nausea, and low blood pressure in a Salmonella infection

E) the excessive secretion of fluids in a Vibrio cholera infection

back 83

B) the invasion and lysis of intestinal cells bycoli

front 84

Polio is transmitted by ingestion of water contaminated with feces containing polio virus. What portal of entry does polio virus use?

A) skin only

B) parenteral only

C) mucous membranes only

D) skin and parenteral

E) skin, parenteral, and mucous membranes

back 84

C) mucous membranes only

front 85

All of the following bacteria release endotoxin EXCEPT

A) Clostridium botulinum.

B) Salmonella typhi.

C) Neisseria meningitidis.

D) Proteus vulgaris.

E) Haemophilus influenzae.

back 85

A) Clostridium botulinum.

front 86

Cholera toxin polypeptide A binds to surface gangliosides on target cells. If the gangliosides were removed,

A) polypeptide A would bind to target cells.

B) polypeptide A would enter the cells.

C) polypeptide B would not be able to enter the cells.

D) Vibrio would not produce cholera toxin.

E) Vibrio would bind to target cells.

back 86

C) polypeptide B would not be able to enter the cells.

front 87

Bacteria such as E. coli and Salmonella produce invasins that bind host cells, thus causing the cells to

A) release TNF.

B) produce iron-binding proteins.

C) engulf the bacteria.

D) destroy the bacteria.

E) release cytokines.

back 87

C) engulf the bacteria.

front 88

Which of the following mechanisms is used by gram-negative bacteria to cross the blood-brain barrier?

A) producing fimbriae

B) inducing endocytosis

C) producing toxins

D) inducing TNF

E) antigenic variation

back 88

D) inducing TNF

front 89

Injectable drugs are tested for endotoxins by

A) the Limulus amoebocyte lysate test.

B) counting the viable bacteria.

C) filtering out the cells.

D) looking for turbidity.

E) culturing bacteria.

back 89

A) the Limulus amoebocyte lysate test.

front 90

Endotoxins in sterile injectable drugs could cause

A) infection.

B) septic shock symptoms.

C) giant cell formation.

D) nerve damage.

E) no damage, because they are sterile.

back 90

B) septic shock symptoms.

front 91

Gram-negative septic shock results from the following events. What is the second step?

A) Body temperature is reset in the hypothalamus.

B) Fever occurs.

C) IL-1 is released.

D) LPS is released from gram-negative bacteria.

E) Phagocytes ingest gram-negative bacteria.

back 91

D) LPS is released from gram-negative bacteria.

front 92

Antibiotics can lead to septic shock if used to treat

A) viral infections.

B) gram-negative bacterial infections.

C) gram-positive bacterial infections.

D) protozoan infections.

E) helminth infestations.

back 92

B) gram-negative bacterial infections.

front 93

Which of the following is NOT a cytopathic effect of viruses?

A) cell death

B) host cells fusing to form multinucleated syncytia

C) inclusion bodies forming in the cytoplasm or nucleus

D) increased cell growth

E) toxin production

back 93

E) toxin production

front 94

Table 15.1 shows the ID50 for Staphylococcus aureus in wounds with and without the administration of ampicillin before surgery. Based on the data, the administration of ampicillin before surgery

A) decreases the risk of staphylococcal infection.

B) increases the risk of staphylococcal infection.

C) has no effect on risk of infection.

D) replaces tetracycline.

E) The answer cannot be determined based on the information provided.

back 94

A) decreases the risk of staphylococcal infection.

front 95

Which organism in Table 15.2 most easily causes an infection?

A) coli O157:H7

B) Legionella pneumophila

C) Shigella

D) Treponema pallidum

E) The answer cannot be determined based on the information provided.

back 95

B) Legionella pneumophila

front 96

Which organism in Table 15.2 causes the most severe disease?

A) coli O157:H7

B) Legionella pneumophila

C) Shigella

D) Treponema pallidum

E) It cannot be determined from the information provided.

back 96

E) It cannot be determined from the information provided.

front 97

Bacteria that cause periodontal disease have adhesins for receptors on streptococci that colonize on teeth. This indicates that

A) streptococci get bacterial infections.

B) streptococcal colonization is necessary for periodontal disease.

C) bacteria that cause periodontal disease adhere to gums and teeth.

D) bacteria that cause periodontal disease adhere to teeth.

E) streptococci cause periodontal disease.

back 97

B) streptococcal colonization is necessary for periodontal disease.

front 98

Nonpathogenic Vibrio cholerae can acquire the cholera toxin gene by

A) phagocytosis.

B) transduction.

C) conjugation.

D) transformation.

E) infecting a pathogenic Vibrio cholerae.

back 98

B) transduction.

front 99

In response to the presence of endotoxin, phagocytes secrete tumor necrosis factor. This causes

A) the disease to subside.

B) a decrease in blood pressure.

C) a fever.

D) a gram-negative infection.

E) an increase in red blood cells.

back 99

B) a decrease in blood pressure.

front 100

Patients developed inflammation a few hours following eye surgery. Instruments and solutions were sterile, and the Limulus assay was positive. The patients' inflammation was due to

A) bacterial infection.

B) viral infection.

C) endotoxin.

D) exotoxin.

E) The answer cannot be determined based on the information provided

back 100

C) endotoxin.

front 101

In general, the LD50 for exotoxins is much greater than the LD50 for endotoxins.

True/False

back 101

FALSE

front 102

Biofilms provide pathogens with an adhesion mechanism and aid in resistance to antimicrobial agents.

True/False

back 102

TRUE

front 103

The M protein enhances the virulence of Streptococcus by preventing phagocytosis.

True/False

back 103

TRUE

front 104

In A-B exotoxins, the A component binds to the host cell receptor so that the B component can enter the cell.

True/False

back 104

FALSE

front 105

The Limulus amoebocyte assay is used to detect minute amounts of endotoxin in drugs and medical devices.

True/False

back 105

TRUE

front 106

Cytopathic effects, such as inclusion bodies and syncytium formation, are the visible signs of viral infections.

True/False

back 106

TRUE

front 107

Ergot and aflatoxin are toxins sometimes found in grains contaminated with fungi.

True/False

back 107

TRUE

front 108

Most symptoms of endotoxins can be treated with administration of anti-endotoxin antibodies.

True/False

back 108

FALSE

front 109

Infections with some viruses may induce chromosomal changes that alter the growth properties of host cells.

True/False

back 109

TRUE

front 110

Many pathogens use the same portal for entry and exit from the body.

True/False

back 110

TRUE

front 111

Innate immunity

A) is slower than adaptive immunity in responding to pathogens.

B) is nonspecific and present at birth.

C) involves a memory component.

D) involves T cells and B cells.

E) provides increased susceptibility to disease.

back 111

B) is nonspecific and present at birth.

front 112

All of the following protect the skin and mucous membranes from infection EXCEPT

A) multiple layers of cells.

B) tears.

C) saliva.

D) HCl.

E) the "ciliary escalator."

back 112

D) HCl.

front 113

The function of the "ciliary escalator" is to

A) propel inhaled dust and microorganisms toward the mouth, away from the lower respiratory tract.

B) remove microorganisms from the gastrointestinal tract.

C) remove microorganisms from the lower respiratory tract.

D) trap microorganisms in mucus in the upper respiratory tract.

E) trap inhaled dust and microorganisms in mucus and propel it away from the lower respiratory tract.

back 113

E) trap inhaled dust and microorganisms in mucus and propel it away from the lower respiratory tract.

front 114

Which of the following exhibits the highest phagocytic activity?

A) eosinophils

B) erythrocytes

C) macrophages

D) basophils

E) neutrophils

back 114

C) macrophages

front 115

TLRs attach to all of the following EXCEPT

A) AMPs.

B) flagellin.

C) LPS.

D) PAMPs.

E) peptidoglycan.

back 115

A) AMPs.

front 116

A differential cell count is used to determine each of the following EXCEPT

A) the total number of white blood cells.

B) the numbers of each type of white blood cell.

C) the number of red blood cells.

D) leukocytosis.

E) leukopenia.

back 116

C) the number of red blood cells.

front 117

The complement protein cascade is the same for the classical pathway, alternative pathway, and lectin pathway after the point in the cascade where the activation of ________ takes place.

A) C1

B) C2

C) C3

D) C5

E) C6

back 117

C) C3

front 118

All of the following increase blood vessel permeability EXCEPT

A) kinins.

B) prostaglandins.

C) lysozymes.

D) histamine.

E) leukotrienes.

back 118

C) lysozymes.

front 119

A child falls and suffers a deep cut on her leg. The cut went through her skin and she is bleeding. Which of the following defense mechanisms will participate in eliminating contaminating microbes?

A) mucociliary escalator

B) normal skin flora

C) phagocytosis in the inflammatory response

D) acidic skin secretions

E) lysozyme

back 119

C) phagocytosis in the inflammatory response

front 120

Margination refers to

A) the adherence of phagocytes to microorganisms.

B) the chemotactic response of phagocytes.

C) adherence of phagocytes to the lining of blood vessels.

D) dilation of blood vessels.

E) the movement of phagocytes through walls of blood vessels.

back 120

C) adherence of phagocytes to the lining of blood vessels.

front 121

Which of the following statements is TRUE?

A) All three types of interferons have the same effect on the body.

B) Alpha interferon promotes phagocytosis.

C) Gamma interferon causes bactericidal activity by macrophages.

D) Alpha interferon acts against specific viruses.

E) Beta interferon attacks invading viruses.

back 121

C) Gamma interferon causes bactericidal activity by macrophages.

front 122

Which of the following is found normally in serum?

A) complement

B) interferon

C) histamine

D) leukocytosis-promoting factor

E) TLRs

back 122

A) complement

front 123

Each of the following is an effect of complement activation EXCEPT

A) interference with viral replication.

B) bacterial cell lysis.

C) opsonization.

D) increased phagocytic activity.

E) increased blood vessel permeability.

back 123

A) interference with viral replication.

front 124

Which of the following is an effect of opsonization?

A) increased adherence of phagocytes to microorganisms

B) increased margination of phagocytes

C) increased diapedesis of phagocytes

D) inflammation

E) cytolysis

back 124

A) increased adherence of phagocytes to microorganisms

front 125

Normal microbiota provide protection from infection in each of the following ways EXCEPT

A) they produce antibacterial chemicals.

B) they compete with pathogens for nutrients.

C) they make the chemical environment unsuitable for nonresident bacteria.

D) they produce lysozyme.

E) they change the pH of the environment.

back 125

D) they produce lysozyme.

front 126

Each of the following provides protection from phagocytic digestion EXCEPT

A) M protein.

B) capsules.

C) formation of phagolysosomes.

D) leukocidins.

E) biofilms.

back 126

C) formation of phagolysosomes.

front 127

The antimicrobial effects of AMPs include all of the following EXCEPT

A) inhibition of cell wall synthesis.

B) lysis of bacterial cells.

C) destruction of nucleic acids.

D) pore formation in bacterial membranes.

E) inhibition of phagocytosis.

back 127

E) inhibition of phagocytosis.

front 128

The swelling associated with inflammation decreases when the fluid

A) returns to the blood.

B) goes into lymph capillaries.

C) is excreted in urine.

D) is lost as perspiration.

E) is transported into macrophages.

back 128

B) goes into lymph capillaries.

front 129

Which of the following statements about fixed macrophages is FALSE?

A) They are found in certain tissues and organs.

B) They develop from neutrophils.

C) They are cells of the mononuclear phagocytic system.

D) They are mature monocytes.

E) They gather at sites of infection.

back 129

B) They develop from neutrophils.

front 130

Phagocytes utilize all of the following to optimize interaction with (getting to and getting hold of) microorganisms EXCEPT

A) trapping a bacterium against a rough surface.

B) opsonization.

C) chemotaxis.

D) lysozyme.

E) complement.

back 130

D) lysozyme.

front 131

All of the following are effects of histamine EXCEPT

A) vasodilation.

B) fever.

C) swelling.

D) redness.

E) pain.

back 131

B) fever.

front 132

All of the following are effects of histamine EXCEPT

A) destruction of an injurious agent.

B) removal of an injurious agent.

C) isolation of an injurious agent.

D) repair of damaged tissue.

E) production of antibodies.

back 132

E) production of antibodies.

front 133

A chill is a sign that

A) body temperature is falling.

B) body temperature is rising.

C) body temperature is not changing.

D) the metabolic rate is decreasing.

E) blood vessels are dilating.

back 133

B) body temperature is rising.

front 134

Which of the following statements is TRUE?

A) There are at least thirty complement proteins.

B) All of the complement proteins are constantly active in serum.

C) Factors B, D, and P cause cytolysis.

D) Complement activity is antigen-specific.

E) Complement increases after immunization.

back 134

A) There are at least thirty complement proteins.

front 135

Which of the following is mismatched?

A) diapedesis — movement of leukocytes between capillary walls cells out of blood and into tissue

B) chemotaxis — chemical degradation inside a phagolysosome

C) abcess — a cavity created by tissue damage and filled with pus

D) pus — tissue debris and dead phagocytes in a white or yellow fluid

E) scab — dried blood clot over injured tissue

back 135

B) chemotaxis — chemical degradation inside a phagolysosome

front 136

All of the following are part of the mechanism of action of alpha and beta interferons EXCEPT

A) they bind to the surface of uninfected cells.

B) they are effective for long periods.

C) they initiate manufacture of antiviral proteins.

D) they disrupt stages of viral multiplication.

E) they initiate transcription.

back 136

B) they are effective for long periods.

front 137

The alternative pathway for complement activation is initiated by

A) lipid-carbohydrate complexes and C3.

B) C5-C9.

C) antigen-antibody reactions.

D) factors released from phagocytes.

E) factors released from damaged tissues.

back 137

A) lipid-carbohydrate complexes and C3.

front 138

The classical pathway for complement activation is initiated by

A) lipid-carbohydrate complexes and C3.

B) C5-C9.

C) antigen-antibody reactions.

D) factors released from phagocytes.

E) factors released from damaged tissues.

back 138

C) antigen-antibody reactions.

front 139

Activation of C3a results in

A) acute inflammation.

B) increased blood vessel permeability.

C) opsonization.

D) attraction of phagocytes.

E) cell lysis.

back 139

A) acute inflammation.

front 140

Neutrophils with defective lysosomes are unable to

A) undergo chemotaxis.

B) migrate.

C) produce toxic oxygen products.

D) attach to microorganisms and other foreign material.

E) engulf microorganisms and other foreign material.

back 140

C) produce toxic oxygen products.

front 141

Innate immunity includes all of the following EXCEPT

A) phagocytosis.

B) inflammation.

C) production of antibody.

D) production of interferon.

E) activation of complement.

back 141

C) production of antibody.

front 142

After ingesting a pathogen, lysosomal enzymes produce all of the following EXCEPT

A) complement.

B) O2-.

C) H2O2.

D) OH.

E) HOCl.

back 142

A) complement.

front 143

Activation of C5-C9 results in

A) activation of C3.

B) fixation of complement.

C) lysis of microbial cells.

D) phagocytosis.

E) inflammation.

back 143

C) lysis of microbial cells.

front 144

All of the following are true regarding NK cells EXCEPT

A) they are a type of lymphocyte.

B) they are found in tissues of the lymphatic system.

C) they have the ability to kill infected body cells and some tumor cells.

D) they destroy infected body cells by phagocytosis.

E) they release toxic substances that cause cell lysis or apoptosis.

back 144

D) they destroy infected body cells by phagocytosis.

front 145

Which of the following is involved in resistance to parasitic helminths?

A) basophils

B) eosinophils

C) lymphocytes

D) monocytes

E) neutrophils

back 145

B) eosinophils

front 146

Macrophages arise from which of the following?

A) basophils

B) eosinophils

C) lymphocytes

D) monocytes

E) neutrophils

back 146

D) monocytes

front 147

All of the following pertain to fever EXCEPT that it

A) accelerates microbial growth by increasing iron absorption from the digestive tract.

B) stimulates T lymphocyte activity.

C) is caused by interleukin-1 and TNF-alpha coming into contact with the hypothalamus.

D) intensifies the effect of antiviral interferons.

E) can be initiated by specific types of pathogens.

back 147

A) accelerates microbial growth by increasing iron absorption from the digestive tract.

front 148

All of the following are iron-binding proteins found in humans EXCEPT

A) lactoferrin.

B) transferrin.

C) hemoglobin.

D) siderophorin.

E) ferritin.

back 148

D) siderophorin.

front 149

All of the following occur during inflammation. What is the first step?

A) diapedesis

B) margination

C) phagocyte migration

D) repair

E) vasodilation

back 149

E) vasodilation

front 150

The lectin pathway for complement action is initiated by

A) mannose on host membranes.

B) mannose on the surface of microbes.

C) lectins of the microbe.

D) gram-negative cell walls.

E) gram-positive cell walls.

back 150

B) mannose on the surface of microbes.

front 151

All of the following are components of the inflammatory process EXCEPT

A) dilation of blood vessels.

B) release of histamines and prostaglandins.

C) chemotaxis.

D) diapedesis.

E) antibody synthesis.

back 151

E) antibody synthesis.

front 152

Several inherited deficiencies in the complement system occur in humans. Which of the following would be the MOST severe?

A) deficiency of C3

B) deficiency of C5

C) deficiency of C6

D) deficiency of C7

E) deficiency of C8

back 152

A) deficiency of C3

front 153

Which of the following statements about the classical pathway of complement activation is FALSE?

A) C1 is the first protein activated in the classical pathway.

B) The C1 protein complex is initiated by antigen-antibody complexes.

C) C3 is not involved in the classical pathway.

D) Cleaved fragments of some of the proteins act to increase inflammation.

E) C3b causes opsonization.

back 153

C) C3 is not involved in the classical pathway.

front 154

Lysozyme and the antibiotic penicillin have similar mechanisms of action in that they both cause damage to the bacterial

A) cell membrane.

B) capsule.

C) cell wall.

D) DNA.

E) ribosomes.

back 154

C) cell wall.

front 155

Which non-specific defense mechanism is mismatched with its associated body structure or body fluid?

A) lysozyme — tears and saliva

B) mucociliary escalator — intestines

C) very acidic pH — stomach

D) keratin and tightly packed cells — skin

E) cerumen and sebum — ear

back 155

B) mucociliary escalator — intestines

front 156

The dermis is composed of connective tissue and serves the primary purpose of providing direct protection from the external environment.

True/False

back 156

FALSE

front 157

Microorganisms that are members of the normal microbiota are also known to cause disease.

True/False

back 157

TRUE

front 158

Maturation of stem cells into mature blood cells occurs in the red bone marrow.

True/False

back 158

TRUE

front 159

The inflammatory response can only be triggered by an infection.

True/False

back 159

FALSE

front 160

Histamine and kinins cause increased blood flow and capillary permeability.

True/False

back 160

TRUE

front 161

Aspirin alleviates pain, inflammation, and fever by inhibiting prostaglandins.

True/False

back 161

TRUE

front 162

Complement proteins in their intact and unactivated form act as opsonins by binding to microorganisms and promoting phagocytosis.

True/False

back 162

FALSE

front 163

Digestion of microorganisms occurs in phagosomes.

True/False

back 163

FALSE

front 164

An example of a TLR would be peptidoglycan found in the cell wall of gram-positive bacteria.

True/False

back 164

FALSE

front 165

Ingestion of certain lactic acid bacteria (LABs) has been shown to be beneficial for function and health of the intestinal tract.

True/False

back 165

TRUE

front 166

What type of immunity results from vaccination?

A) innate immunity

B) naturally acquired active immunity

C) naturally acquired passive immunity

D) artificially acquired active immunity

E) artificially acquired passive immunity

back 166

D) artificially acquired active immunity

front 167

What type of immunity results from transfer of antibodies from one individual to a susceptible individual by means of injection?

A) innate immunity

B) naturally acquired active immunity

C) naturally acquired passive immunity

D) artificially acquired active immunity

E) artificially acquired passive immunity

back 167

E) artificially acquired passive immunity

front 168

What type of immunity results from recovery from mumps?

A) innate immunity

B) naturally acquired active immunity

C) naturally acquired passive immunity

D) artificially acquired active immunity

E) artificially acquired passive immunity

back 168

B) naturally acquired active immunity

front 169

Which of the following is the best definition of epitope?

A) specific regions on antigens that interact with T-cell receptors

B) specific regions on antigens that interact with MHC class molecules

C) specific regions on antigens that interact with haptens

D) specific regions on antigens that interact with antibodies

E) specific regions on antigens that interact with perforins

back 169

D) specific regions on antigens that interact with antibodies

front 170

Newborns' immunity due to the transfer of antibodies across the placenta is an example of

A) innate immunity.

B) naturally acquired active immunity.

C) naturally acquired passive immunity.

D) artificially acquired active immunity.

E) artificially acquired passive immunity.

back 170

C) naturally acquired passive immunity.

front 171

Which of the following statements is NOT a possible outcome of antigen-antibody reaction?

A) clonal deletion

B) activation of complement

C) opsonization

D) ADCC

E) agglutination

back 171

A) clonal deletion

front 172

Which of the following cells is NOT an APC?

A) dentritic cells

B) macrophages

C) mature B cells

D) natural killer cells

E) None of the answers is correct; all of these are APCs.

back 172

D) natural killer cells

front 173

When an antibody binds to a toxin, the resulting action is referred to as

A) agglutination.

B) opsonization.

C) ADCC.

D) apoptosis.

E) neutralization.

back 173

E) neutralization.

front 174

CD4+ T cells are activated by

A) interaction between CD4+and MHC II.

B) interaction between TCRs and MHC II.

C) cytokines released by dendritic cells.

D) cytokines released by B cells.

E) complement.

back 174

A) interaction between CD4+and MHC II.

front 175

Which of the following recognizes antigens displayed on host cells with MHC II?

A) TCcell

B) B cell

C) THcell

D) natural killer cell

E) basophil

back 175

C) THcell

front 176

The specificity of an antibody is due to

A) its valence.

B) the H chains.

C) the L chains.

D) the constant portions of the H and L chains.

E) the variable portions of the H and L chains.

back 176

E) the variable portions of the H and L chains.

front 177

Which of the following is NOT a characteristic of B cells?

A) They originate in bone marrow.

B) They have antibodies on their surfaces.

C) They are responsible for the memory response.

D) They are responsible for antibody formation.

E) They recognize antigens associated with MHC I.

back 177

E) They recognize antigens associated with MHC I.

front 178

Which of the following is NOT a characteristic of cellular immunity?

A) The cells originate in bone marrow.

B) Cells are processed in the thymus gland.

C) It can inhibit the immune response.

D) B cells make antibodies.

E) T cells react with antigens.

back 178

D) B cells make antibodies.

front 179

Plasma cells are activated by a(n)

A) antigen.

B) T cell.

C) B cell.

D) memory cell.

E) APC.

back 179

A) antigen.

front 180

The antibodies found in mucus, saliva, and tears are

A) IgG.

B) IgM.

C) IgA.

D) IgD.

E) IgE.

back 180

C) IgA.

front 181

The antibodies found almost entirely and only on the surface of B cells (not secreted from them), and which always exist as monomers, are

A) IgG.

B) IgM.

C) IgA.

D) IgD.

E) IgE.

back 181

D) IgD.

front 182

The antibodies that can bind to large parasites are

A) IgG.

B) IgM.

C) IgA.

D) IgD.

E) IgE.

back 182

E) IgE.

front 183

In addition to IgG, the antibodies that can fix complement are

A) IgM.

B) IgA.

C) IgD.

D) IgE.

E) None of the answers is correct.

back 183

A) IgM.

front 184

Large antibodies that agglutinate antigens are

A) IgG.

B) IgM.

C) IgA.

D) IgD.

E) IgE.

back 184

B) IgM.

front 185

The most abundant class of antibodies in serum is

A) IgG.

B) IgM.

C) IgA.

D) IgD.

E) IgE.

back 185

A) IgG.

front 186

In Figure 17.1, which letter on the graph indicates the patient's secondary response to a repeated exposure with the identical antigen?

A) a

B) b

C) c

D) d

E) e

back 186

C) c

front 187

In Figure 17.1, which letter on the graph indicates the highest antibody titer during the patient's response to a second and distinct/different antigen?

A) a

B) b

C) c

D) d

E) e

back 187

E) e

front 188

In Figure 17.1, the arrow at time (c) indicates

A) the time of exposure to the same antigen as at time (a).

B) the secondary response.

C) the primary response.

D) exposure to a new antigen.

E) the T-cell response.

back 188

B) the secondary response.

front 189

Which of the following statements is FALSE?

A) The variable region of a heavy chain is partially responsible for binding with antigen.

B) The variable region of a light chain is partially responsible for binding with antigen.

C) The Fc region attaches to a host cell.

D) The constant region of a heavy chain is the same for all antibodies.

E) All of the answers are correct.

back 189

D) The constant region of a heavy chain is the same for all antibodies.

front 190

Which of the following is the best definition of antigen?

A) something foreign in the body

B) a chemical that elicits an antibody response and can combine with these antibodies

C) a chemical that combines with antibodies

D) a pathogen

E) a protein that combines with antibodies

back 190

B) a chemical that elicits an antibody response and can combine with these antibodies

front 191

Which of the following WBCs are NOT lymphocytes?

A) cytotoxic T cells

B) helper T cells

C) NK cells

D) M cells

E) B cells

back 191

D) M cells

front 192

The following events elicit an antibody response. What is the third step?

A) Antigen-digest goes to surface of APC.

B) APC phagocytizes antigen.

C) B cell is activated.

D) THcell recognizes antigen-digest and MHC II.

E) THcell produces cytokines.

back 192

D) THcell recognizes antigen-digest and MHC II.

front 193

) In Figure 17.2, which areas are similar for all IgG antibodies?

A) a and b

B) a and c

C) b and c

D) c and d

E) b and d

back 193

D) c and d

front 194

In Figure 17.2, which areas are different for all IgM antibodies?

A) a and b

B) a and c

C) b and c

D) c and d

back 194

A) a and b

front 195

In Figure 17.2, which areas represent antigen-binding sites?

A) a and b

B) a and c

C) b and c

D) c and d

E) b and d

back 195

A) a and b

front 196

In Figure 17.2, what portion will typically attach to a host cell?

A) a and c

B) b

C) b and c

D) a and d

E) e

back 196

E) e

front 197

Which of the following bacterial components would most likely result in B cell stimulation by T-independent antigens?

A) capsule

B) flagellum

C) pili

D) ribosome

E) plasmid

back 197

A) capsule

front 198

The presence of which of the following indicates a current infection rather than a previous infection or vaccination?

A) IgA

B) IgG

C) IgM

D) IgD

E) IgE

back 198

C) IgM

front 199

Which of the following destroys virus-infected cells?

A) CTL

B) Treg

C) TH

D) dendritic cells

E) B cells

back 199

A) CTL

front 200

The following events occur in cellular immunity, leading to a response from TH cells. What is the third step?

A) Antibodies are produced.

B) Dendritic cell takes up antigen.

C) Antigen enters M cell.

D) THcell produces cytokines.

E) THcells proliferate.

back 200

E) THcells proliferate.

front 201

Cytokines released by TH1 cells

A) activate CD8+cells to CTLs.

B) convert TH1 cells to TH2 cells.

C) convert TH2 cells to TH1 cells.

D) kill parasites.

E) convert B cells to T cells.

back 201

A) activate CD8+cells to CTLs.

front 202

Which one of the following causes transmembrane channels in target cells?

A) granzymes

B) hapten

C) IL-1

D) IL-2

E) perforin

back 202

E) perforin

front 203

At a minimum, the human immune system is capable of recognizing approximately how many different antigens?

A) 105

B) 1010

C) 1015

D) 1020

E) 1025

back 203

C) 1015

front 204

Thymic selection

A) destroys T cells that do not recognize self-molecules of MHC.

B) destroys B cells that make antibodies against self.

C) destroys MHC molecules.

D) destroys CD4+cells that attack self.

E) activates B cells.

back 204

A) destroys T cells that do not recognize self-molecules of MHC.

front 205

Which of the following statements about natural killer cells is FALSE?

A) They destroy virus-infected cells.

B) They destroy tumor cells.

C) They destroy cells lacking MHC I.

D) They are stimulated by an antigen.

E) None of the answers are correct; all of these statements are true.

back 205

D) They are stimulated by an antigen.

front 206

An antibody's Fc region can be bound by

A) antibodies.

B) macrophages.

C) T helper cells.

D) B cells.

E) CTLs.

back 206

B) macrophages.

front 207

A Treg cell deficiency could result in

A) increased number of viral infections.

B) increased number of bacterial infections.

C) autoimmunity.

D) increased severity of bacterial infections.

E) transplant rejection.

back 207

C) autoimmunity.

front 208

ADCC is a process that is most effective in destroying

A) eukaryotic pathogens.

B) prions.

C) extracellular viruses.

D) bacterial pathogens.

E) bacterial toxins.

back 208

A) eukaryotic pathogens.

front 209

IL-2, produced by TH cells,

A) activates macrophages.

B) stimulates THcell maturation.

C) causes phagocytosis.

D) activates antigen-presenting cells.

E) activates TCcells to CTLs.

back 209

B) stimulates THcell maturation.

front 210

Which of the following statements about IL-12 is FALSE?

A) It activates macrophages.

B) It inhibits some tumor cells.

C) It activates the TH1 pathway.

D) It causes autoimmune diseases.

E) It causes THcells to respond to HIV.

back 210

D) It causes autoimmune diseases.

front 211

Apoptosis results in significant leakage of cellular contents.

TRUE/FALSE

back 211

FALSE

front 212

Cytokines are protein-based chemical messengers that allow for communication between cells of the immune system.

TRUE/FALSE

back 212

TRUE

front 213

Only dendritic cells produce interleukins

TRUE/FALSE

back 213

FALSE

front 214

The production of interferons at an infection site is critical for chemotaxis.

TRUE/FALSE

back 214

FALSE

front 215

Cytokine storms negatively impact human health.

TRUE/FALSE

back 215

TRUE

front 216

The variable region of the antibody is solely responsible the significant diversity of antigen targets

TRUE/FALSE

back 216

FALSE

front 217

Plasma cells will eventually differentiate into memory cells.

TRUE/FALSE

back 217

FALSE

front 218

Memory cells do not require B cell receptors.

TRUE/FALSE

back 218

FALSE

front 219

The implementation of vaccinations occurred prior to experimental support for the germ theory of disease.

TRUE/FALSE

back 219

TRUE

front 220

When haptens attach to carrier molecules, an epitope forms on hapten which then can be bound to antibody.

TRUE/FALSE

back 220

FALSE

front 221

All of the following are true of hypersensitivity EXCEPT

A) it occurs in the presence of an antigen.

B) it is synonymous with "allergy."

C) it occurs when an individual is exposed to an allergen for the first time.

D) it is due to an altered immune response.

E) it requires previous exposure to an antigen.

back 221

C) it occurs when an individual is exposed to an allergen for the first time.

front 222

The chemical mediators of anaphylaxis are

A) found in basophils and mast cells.

B) antibodies.

C) antigens.

D) antigen-antibody complexes.

E) the proteins of the complement system.

back 222

A) found in basophils and mast cells.

front 223

Which of the following may result from systemic anaphylaxis?

A) hay fever

B) asthma

C) shock

D) hives

E) immunodeficiency

back 223

C) shock

front 224

Which antibodies will be in the serum of a person with blood type B, Rh+?

A) anti-A, anti-B, anti-Rh

B) anti-A, anti-Rh

C) anti-A

D) anti-B, anti-Rh

E) anti-B

back 224

C) anti-A

front 225

Which of the following types of transplant is least compatible?

A) autograft

B) allograft

C) isograft

D) xenotransplant

E) All of these types of transplant are equally compatible.

back 225

D) xenotransplant

front 226

When testing donated blood for compatibility you would find a person with O type blood

A) has O type antigens on their red blood cells.

B) will lack plasma antibodies to A and B type antigens.

C) will lack A and B red blood cell antigens.

D) lacks HLA and MHC antigens.

E) will have anti-O antibodies in their plasma.

back 226

C) will lack A and B red blood cell antigens.

front 227

Graft-versus-host disease will most likely be a complication of a(n)

A) skin graft.

B) bone marrow transplant.

C) blood transfusion.

D) Rh incompatibility between mother and fetus.

E) corneal transplant.

back 227

B) bone marrow transplant.

front 228

A positive tuberculin skin test is an example of

A) delayed cell-mediated immunity.

B) autoimmunity.

C) acute contact dermatitis.

D) psoriasis.

E) innate immunity.

back 228

A) delayed cell-mediated immunity.

front 229

A healthy immune system destroys cancer cells with

A) tumor-specific antigens.

B) CTLs.

C) CTLs and activated macrophages.

D) activated macrophages.

E) CD+T cells.

back 229

C) CTLs and activated macrophages.

front 230

The symptoms of an immune complex reaction are due to

A) destruction of the antigen.

B) complement activation.

C) phagocytosis.

D) antibodies against self.

E) cytokines.

back 230

B) complement activation.

front 231

Rheumatoid arthritis is due to deposition of

A) IgG and IgA complexes in joints.

B) IgA antibodies in joints.

C) IgD and IgE complexes in joints.

D) complement in joints.

E) complexes of IgM and IgG and also complement in joints.

back 231

E) complexes of IgM and IgG and also complement in joints.

front 232

Allergic contact dermatitis is due to

A) sensitized T cells.

B) IgG antibodies.

C) IgE antibodies.

D) IgM antibodies.

E) activated macrophages.

back 232

A) sensitized T cells.

front 233

Attachment of HIV to the target cell depends on

A) gp120 combining with the CD4+

B) gp120 combining with the chemokine receptor CCR5.

C) gp41 binding to the CD4+

D) gp120 binding to the CD4+plasma membrane.

E) CXCR4 binding to the CD4+

back 233

A) gp120 combining with the CD4+

front 234

All of the following pertain to serological tests EXCEPT

A) they can detect antibodies but not antigens.

B) they can be used to diagnose various diseases.

C) reactions can be detected by uptake of trypan blue by damaged cells.

D) they are used to test for specific HLAs on lymphocytes.

E) they are used to detect compatible tissues for transplantation

back 234

A) they can detect antibodies but not antigens.

front 235

The process of desensitization to prevent allergies involves the injection of increasing amounts of

A) IgE.

B) IgG.

C) antihistamine.

D) antigen.

E) RhoGAM.

back 235

D) antigen.

front 236

Which of the following statements about type I reactions is FALSE?

A) They involve helper T cells.

B) They involve IgE antibodies.

C) The symptoms are due to histamine.

D) Antibodies bind to mast cells and basophils.

E) The symptoms occur soon after exposure to an antigen.

back 236

A) They involve helper T cells.

front 237

Which of the following statements about type IV reactions is FALSE?

A) Reactions are primarily due to T cell proliferation.

B) Reactions are not apparent for a day or more.

C) Cytokines initiate tissue damage.

D) Allergic contact dermatitis is an example.

E) Hemolytic disease of the newborn is an example.

back 237

E) Hemolytic disease of the newborn is an example.

front 238

Which blood transfusions in Table 19.1 are incompatible?

A) 2 and 5

B) 1, 2, and 3

C) 2, 3, and 5

D) 3 and 4

E) 1 and 2

back 238

C) 2, 3, and 5

front 239

Hemolytic disease of the newborn can result from an

A) Rh+mother with an Rh-

B) Rh-mother with an Rh+

C) AB mother with a B fetus.

D) AB mother with an O fetus.

E) Rh-mother and an A fetus.

back 239

B) Rh-mother with an Rh+

front 240

Which is true regarding Herceptin therapy?

A) It neutralizes the growth factor EGF.

B) It acts as an immunotoxin to target and kill cancer cells.

C) It is used to treat some breast cancer patients.

D) It is a vaccine to prevent the development of cancer.

E) It is an endotoxin that stimulates TNF by macrophages.

back 240

C) It is used to treat some breast cancer patients.

front 241

Which of the following utilizes a combination of monoclonal antitumor antibody and immunotoxin?

A) immunologic enhancement

B) immunologic surveillance

C) immunotherapy

D) immunosuppression

E) immune complex

back 241

C) immunotherapy

front 242

All of the following are reasons why an HIV vaccine has not been developed EXCEPT

A) there is no known animal model of natural immunity for HIV infection.

B) use of a weakened virus would potentially transmit the infection.

C) small, inexpensive animals which could be used for HIV vaccine research are not available.

D) vaccines are not effective against viral infections.

E) HIV has a high mutation rate so one vaccination would not be effective to treat the world-wide pandemic.

back 242

D) vaccines are not effective against viral infections.

front 243

Treatment with certain drugs to reduce transplant rejection can cause

A) immunologic enhancement.

B) immunologic surveillance.

C) immunotherapy.

D) immunosuppression.

E) autoimmunity.

back 243

D) immunosuppression.

front 244

Which of the following statements about human embryonic stem cells is TRUE?

A) They are obtained in great numbers from umbilical cords of newborns.

B) They express no MHC II antigens.

C) They are pluripotent.

D) They are typically obtained from the zygote stage of embryonic development.

E) They are pluripotent and typically obtained from the blastocyst stage of embryonic development.

back 244

E) They are pluripotent and typically obtained from the blastocyst stage of embryonic development.

front 245

In immune complex reaction shown in Figure 19.1, what is the small, circular/spherical structure labeled "a"?

A) antibody

B) antigen

C) complement

D) neutrophil

E) mast cell

back 245

B) antigen

front 246

In immune complex reaction shown in Figure 19.1, what is the end result of the reaction?

A) IgG is directed against cell membrane antigens.

B) Complement is activated.

C) Neutrophils are attracted and release enzymes.

D) Endothelial cells are damaged.

E) Antibodies destroy neutrophils.

back 246

D) Endothelial cells are damaged.

front 247

Worldwide, the primary method of transmission of HIV is

A) heterosexual intercourse.

B) homosexual intercourse.

C) intravenous drug use.

D) blood transfusions.

E) nosocomial.

back 247

A) heterosexual intercourse.

front 248

HIV spikes attach to CD4+ receptors found on

A) T helper cells.

B) macrophages.

C) dendritic cells.

D) T helper cells and macrophages.

E) T helper cells, macrophages, and dendritic cells.

back 248

E) T helper cells, macrophages, and dendritic cells.

front 249

Which of the following is the least likely vaccine against HIV?

A) attenuated virus

B) glycoprotein

C) protein core

D) subunit

E) All of these vaccines are equally likely.

back 249

A) attenuated virus

front 250

Which of the following is a possible outcome of an HIV infection?

A) Virions may remain latent.

B) There may be persistent yeast infections.

C) Infection may initially be asymptomatic.

D) The disease does not progress to AIDS.

E) All of the answers are correct.

back 250

E) All of the answers are correct.

front 251

Which of the following regions has the greatest distribution of HIV infection and AIDS in the world?

A) North America

B) Eastern Europe and Central Asia

C) South and Southeast Asia

D) sub-Saharan Africa

E) Latin America

back 251

D) sub-Saharan Africa

front 252

Chemotherapy to inhibit the progression of HIV infection utilizes all of the following mechanisms EXCEPT

A) termination of viral DNA.

B) inhibition of viral proteases.

C) blockage of viral attachment.

D) prohibition of viral integration into host cell DNA.

E) destruction of viral ribosomes.

back 252

E) destruction of viral ribosomes.

front 253

During the asymptomatic phase I of HIV disease, HIV infection is diagnosed by

A) detecting viral RNA.

B) detecting antibodies against HIV.

C) counting CD4+T cells.

D) counting CD8+T cells.

E) the Western blot test.

back 253

A) detecting viral RNA.

front 254

Anaphylaxis is the term for reactions caused when certain antigens combine with

A) IgE antibodies.

B) macrophages.

C) IgG antibodies.

D) complement.

E) histamine.

back 254

A) IgE antibodies.

front 255

All of the following regarding "immune privileged sites" are true EXCEPT

A) they include corneal and brain tissue.

B) they do not have lymphatic vessels.

C) they are rarely rejected.

D) they include any tissue transplanted from a pig.

E) they explain how animals tolerate pregnancies without rejecting the fetus.

back 255

D) they include any tissue transplanted from a pig.

front 256

All of the following are considered examples of type I hypersensitivity EXCEPT

A) asthma.

B) dust allergies.

C) penicillin allergic reactions.

D) pollen allergies.

E) transplant rejections.

back 256

E) transplant rejections.

front 257

Which of the following describes a cytotoxic autoimmune reaction?

A) Antibodies react to cell-surface antigens.

B) Antibodies are not made.

C) Cells are killed.

D) Immune complexes form.

E) Mediate by T cells.

back 257

A) Antibodies react to cell-surface antigens.

front 258

Symptoms of delayed cell-mediated reactions are due to

A) IgE antibodies.

B) neutrophils.

C) cytokines.

D) IgG antibodies.

E) antigens.

back 258

C) cytokines.

front 259

Desensitization involves injection of

A) antigens.

B) IgG antibodies.

C) IgE antibodies.

D) antihistamine.

E) histamine.

back 259

A) antigens.

front 260

In the serological method for tissue typing, if human cells expressing HLA-I are mixed with anti-HLA-I, complement, and trypan blue, what would indicate the cells are HLA-I?

A) Enzyme is released from neutrophils.

B) Cells are damaged by complement.

C) Trypan blue enters the cells.

D) Anti-HLA antibodies bind to HLAs on lymphocytes.

E) None of the answers are correct; the T cells are missing.

back 260

C) Trypan blue enters the cells.

front 261

) In rheumatoid arthritis, IgM, IgG, and complement deposit in joints. This is an example of

A) cytotoxic autoimmunity.

B) immune complex autoimmunity.

C) cell-mediated autoimmunity.

D) immunosuppression.

E) acquired immunodeficiency

back 261

B) immune complex autoimmunity.

front 262

The number of T cells drops to below 200 cells/microliter in which phase of HIV infection?

A) phase 1

B) phase 2

C) phase 3

D) initial phase

E) asymptomatic phase

back 262

C) phase 3

front 263

HIV can evade host antibodies by

A) remaining an inactive provirus.

B) causing cell-to-cell fusion.

C) remaining an inactive provirus, causing cell to cell fusion, and virions remaining latent in vacuoles.

D) lowering the CD4+ cell count.

E) virions remaining latent in vacuoles.

back 263

C) remaining an inactive provirus, causing cell to cell fusion, and virions remaining latent in vacuoles.

front 264

Individuals who do not express CCR5 are highly resistant to infection by HIV.

TRUE/FALSE

back 264

TRUE

front 265

Vaccines against HIV have proven to be very effective in halting the spread of disease.

TRUE/FALSE

back 265

FALSE

front 266

All hypersensitivities involve antibody-antigen reactions.

TRUE/FALSE

back 266

FALSE

front 267

Skin tests are reliable indicators for the diagnosis of food-related allergies.

TRUE/FALSE

back 267

FALSE

front 268

HIV attack of CD4+ T cells causes suppression of both cell-mediated and humoral immune responses.

TRUE/FALSE

back 268

TRUE

front 269

Autoimmune diseases occur when the immune system is unable to discriminate "self" from "nonself."

TRUE/FALSE

back 269

TRUE

front 270

Xenotransplantation is an effective alternative to using isografts.

TRUE/FALSE

back 270

FALSE

front 271

All stem cells are derived from embryonic stem cells.

TRUE/FALSE

back 271

FALSE

front 272

Cancer is similar to an infectious disease in that it is due to a failure of the body's defenses.

TRUE/FALSE

back 272

TRUE

front 273

HIV is believed to have arisen by mutation of a virus endemic to wild animals in Africa.

TRUE/FALSE

back 273

TRUE

front 274

A hypersensitivity reaction refers to immune responses to antigens beyond what would be normal.

TRUE/FALSE

back 274

TRUE