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Chapter 12

front 1

At which phase are centrioles beginning to move apart in animal cells?

back 1

Prophase

front 2

Which of the following describe(s) cyclin-dependent kinase (Cdk)?

back 2

Cdk is present throughout the cell cycle and is an enzyme that attaches phosphate groups to other proteins.

front 3

Which number represents the point in the cell cycle during which the chromosomes are replicated?

back 3

II

front 4

Which of the following was a discovery that had to be made before human chromosomes could be correctly counted?

back 4

how to use a hypotonic solution to swell nuclei

front 5

MPF reaches its threshold concentration at the end of this stage.

back 5

III

front 6

Where do the microtubules of the spindle originate during mitosis in both plant and animal cells?

back 6

centrosome

front 7

Taxol is an anticancer drug extracted from the Pacific yew tree. In animal cells, Taxol disrupts microtubule formation by binding to microtubules and accelerating their assembly from the protein precursor, tubulin. Surprisingly, this stops mitosis. Specifically, Taxol must

back 7

the formation of the mitotic spindle.

front 8

A plant-derived protein known as colchicine can be used to poison cells by blocking the formation of the spindle. Which of the following would result if colchicine is added to a sample of cells in G2?

back 8

The chromosomes would coil and shorten but have no spindle to which to attach

front 9

The centromere is a region in which

back 9

chromatids remain attached to one another until anaphase.

front 10

For a chemotherapeutic drug to be useful for treating cancer cells, which of the following is most desirable?

back 10

It interferes with rapidly dividing cells

front 11

Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to

back 11

disruption of mitotic spindle formation.

front 12

If there are 20 chromatids in a cell, how many centromeres are there?

back 12

10

front 13

After which checkpoint is the cell first committed to continue the cell cycle through M?

back 13

G1

front 14

What is the correct chromosomal condition for one daughter nucleus at telophase of mitosis?

back 14

E

front 15

Besides the ability of some cancer cells to overproliferate, what else could logically result in a tumor?

back 15

lack of appropriate cell death

front 16

Which of the following most accurately describes a cyclin?

back 16

It activates a Cdk molecule when it is in sufficient concentration.

front 17

What is the correct chromosomal condition at the prometaphase of mitosis?

back 17

B

front 18

In the figure above, mitosis is represented by which numbered part(s) of the cycle?

back 18

IV

front 19

What is a cleavage furrow?

back 19

a groove in the plasma membrane between daughter nuclei

front 20

Which of the following does not occur during mitosis?

back 20

replication of the DNA

front 21

Which of the following is a protein maintained at constant levels throughout the cell cycle that requires cyclin to become catalytically active?

back 21

Cdk

front 22

Why do chromosomes coil during mitosis?

back 22

to allow the chromosomes to move without becoming entangled and breaking

front 23

A research team began a study of a cultured cell line. Their preliminary observations showed them that the cell line did not exhibit either density-dependent inhibition or anchorage dependence. What could they conclude right away?

back 23

The cells show characteristics of tumors.

front 24

Density-dependent inhibition is explained by which of the following?

back 24

As cells become more numerous, the cell surface proteins of one cell contact the adjoining cells and they stop dividing.

front 25

Which of the following is a protein maintained at constant levels throughout the cell cycle that requires cyclin to become catalytically active?

back 25

Cdk

front 26

G1 is represented by which numbered part(s) of the cycle?

back 26

I or V

front 27

Which of the following is true concerning cancer cells?

back 27

no data

front 28

Which of the following is a protein synthesized at specific times during the cell cycle that associates with a kinase to form a catalytically active complex?

back 28

cyclin

front 29

At which phase are centrioles beginning to move apart in animal cells?

back 29

Prophase

front 30

Which number represents DNA synthesis?

back 30

II

front 31

Movement of the chromosomes during anaphase would be most affected by a drug that

back 31

prevents shortening of microtubules

front 32

The cyclin component of MPF is destroyed toward the end of which phase?

back 32

M

front 33

Which of the following is released by platelets in the vicinity of an injury?

back 33

PDGF

front 34

If cells in the process of dividing are subjected to colchicine, a drug that interferes with the formation of the spindle apparatus, at which stage will mitosis be arrested?

back 34

metaphase

front 35

The decline of MPF activity at the end of mitosis is due to

back 35

the degradation of cyclin