front 1 At which phase are centrioles beginning to move apart in animal cells? | back 1 Prophase |
front 2 Which of the following describe(s) cyclin-dependent kinase (Cdk)? | back 2 Cdk is present throughout the cell cycle and is an enzyme that attaches phosphate groups to other proteins. |
front 3 Which number represents the point in the cell cycle during which the chromosomes are replicated? | back 3 II |
front 4 Which of the following was a discovery that had to be made before human chromosomes could be correctly counted? | back 4 how to use a hypotonic solution to swell nuclei |
front 5 MPF reaches its threshold concentration at the end of this stage. | back 5 III |
front 6 Where do the microtubules of the spindle originate during mitosis in both plant and animal cells? | back 6 centrosome |
front 7 Taxol is an anticancer drug extracted from the Pacific yew tree. In animal cells, Taxol disrupts microtubule formation by binding to microtubules and accelerating their assembly from the protein precursor, tubulin. Surprisingly, this stops mitosis. Specifically, Taxol must | back 7 the formation of the mitotic spindle. |
front 8 A plant-derived protein known as colchicine can be used to poison cells by blocking the formation of the spindle. Which of the following would result if colchicine is added to a sample of cells in G2? | back 8 The chromosomes would coil and shorten but have no spindle to which to attach |
front 9 The centromere is a region in which | back 9 chromatids remain attached to one another until anaphase. |
front 10 For a chemotherapeutic drug to be useful for treating cancer cells, which of the following is most desirable? | back 10 It interferes with rapidly dividing cells |
front 11 Vinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to | back 11 disruption of mitotic spindle formation. |
front 12 If there are 20 chromatids in a cell, how many centromeres are there? | back 12 10 |
front 13 After which checkpoint is the cell first committed to continue the cell cycle through M? | back 13 G1 |
front 14 What is the correct chromosomal condition for one daughter nucleus at telophase of mitosis? | back 14 E |
front 15 Besides the ability of some cancer cells to overproliferate, what else could logically result in a tumor? | back 15 lack of appropriate cell death |
front 16 Which of the following most accurately describes a cyclin? | back 16 It activates a Cdk molecule when it is in sufficient concentration. |
front 17 What is the correct chromosomal condition at the prometaphase of mitosis? | back 17 B |
front 18 In the figure above, mitosis is represented by which numbered part(s) of the cycle? | back 18 IV |
front 19 What is a cleavage furrow? | back 19 a groove in the plasma membrane between daughter nuclei |
front 20 Which of the following does not occur during mitosis? | back 20 replication of the DNA |
front 21 Which of the following is a protein maintained at constant levels throughout the cell cycle that requires cyclin to become catalytically active? | back 21 Cdk |
front 22 Why do chromosomes coil during mitosis? | back 22 to allow the chromosomes to move without becoming entangled and breaking |
front 23 A research team began a study of a cultured cell line. Their preliminary observations showed them that the cell line did not exhibit either density-dependent inhibition or anchorage dependence. What could they conclude right away? | back 23 The cells show characteristics of tumors. |
front 24 Density-dependent inhibition is explained by which of the following? | back 24 As cells become more numerous, the cell surface proteins of one cell contact the adjoining cells and they stop dividing. |
front 25 Which of the following is a protein maintained at constant levels throughout the cell cycle that requires cyclin to become catalytically active? | back 25 Cdk |
front 26 G1 is represented by which numbered part(s) of the cycle? | back 26 I or V |
front 27 Which of the following is true concerning cancer cells? | back 27 no data |
front 28 Which of the following is a protein synthesized at specific times during the cell cycle that associates with a kinase to form a catalytically active complex? | back 28 cyclin |
front 29 At which phase are centrioles beginning to move apart in animal cells? | back 29 Prophase |
front 30 Which number represents DNA synthesis? | back 30 II |
front 31 Movement of the chromosomes during anaphase would be most affected by a drug that | back 31 prevents shortening of microtubules |
front 32 The cyclin component of MPF is destroyed toward the end of which phase? | back 32 M |
front 33 Which of the following is released by platelets in the vicinity of an injury? | back 33 PDGF |
front 34 If cells in the process of dividing are subjected to colchicine, a drug that interferes with the formation of the spindle apparatus, at which stage will mitosis be arrested? | back 34 metaphase |
front 35 The decline of MPF activity at the end of mitosis is due to | back 35 the degradation of cyclin |