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CBNS101 Lecture 11: Cell Adhesion and Cell Junctions

front 1

T/F The organization of tissues provides mechanical integrity to otherwise squishy cells

back 1

True. They provide integrity

front 2

T/F Tissue organization allows cells to communicate with one another and to perform specialized functions in a coordinated way

back 2

True. The organization allows that

front 3

T/F Tissues don't require cells to recognize and bind to one another in the ECM

back 3

False! They require cells

front 4

What are the 2 architectural extremes of tissues in animal cells?

back 4

Epithelial tissues and connective tissues

front 5

What is the difference between Epithelial and connective tissues?

back 5

Epithelial tissues are like the outer flat covering that is your skin. Connective tissues is all the tissues underneath connecting to your bones and etc.

front 6

What are the 4 types of cell junctions?

back 6

  • Anchoring junctions
  • Occluding junctions
  • Channel forming junctions
  • signal relaying junctions

front 7

What do anchoring junctions do?

back 7

They "anchor" make sure the cells stick together

front 8

What does occluding junctions do?

back 8

They act as like a plug or seal to prevent leaking

front 9

What does channel forming junctions do?

back 9

They force squished cells apart. Like the car thing that pushes the car off the ground. Makes space basically

front 10

What does signal relaying junctions do?

back 10

Neuronal synapses

front 11

What does CAMs stand for?

back 11

Cell Adhesion Molecules

front 12

What are the 4 CAM families?

back 12

  • Cadherins (cell-cell)
  • Integrins (cell-matrix)
  • Selectins (cell-cell in bloodstream)
  • Immunoglobins (Ig)

front 13

Which CAM families have homophilic interactions?

back 13

Cadherins and Immunoglobins

front 14

Which CAM families have heterophilic interactions?

back 14

Integrins and Selectins

front 15

T/F Binding of the extracellular ligand activates signal transduction, resulting in changes to gene expression

back 15

True. It leads to gene expression

front 16

T/F Ca2+ makes Cadherins stiffen up

back 16

True. They stiffen with Ca2+

front 17

What are the 2 main subtypes of Cadherins?

back 17

  • E-cadherin (epithelial)
  • N-cadherin (nerve/muscle)

front 18

T/F Cadherins are important in embryonic development

back 18

True.

  • They hold together embryonic tissue
  • They sort out embryonic cells

front 19

Cadherins are important in adults too. How?

back 19

  • Epithelial cell junctions (holding together of skin)
  • adhesion and synaptic junctions (brains?)

front 20

How is the neural tube formed from cadherins?

back 20

The ectoderm does something like a pinch from endocytosis and the "vesicles" are a variety of cadherins but mainly N cadherin focused

front 21

Tumor cells will reduce the ability of cancerous growth when ______ is expressed.

back 21

cadherins

front 22

What are desmosomes?

back 22

Rivets to intermediate filaments (keratin) joining lots of epithelial cells

front 23

Ig superfamily CAM

back 23

Important in immune and neuronal function.

front 24

Selectins bind using ________ and can be found on leukocytes, endothelial cells and platelets

back 24

sugar residues

front 25

How CAM reacts to an inflammatory response

back 25

Leukocytes flood the system and the selectins help them ingest the damaged or foreign cells which produces pain and swelling

front 26

What is an example of tight junctions in the body?

back 26

Later