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BCH 100 Lecture 16: Glycogen Metabolism

front 1

Where in the body is Glycogen mainly stored?

back 1

In the liver and muscles

front 2

What are the two types of glucose polysaccharide linkages?

back 2

alpha(1->4) makes long chains

alpha(1->6) makes branches

front 3

The more _____ ends you have, the ______ you build up and break down glucose

back 3

More, quicker

front 4

Glycogen Metabolism

back 4

-Review slide 4 and practice drawing the mech?

front 5

When does glycogen breakdown happen?

back 5

During the four Fs and low blood sugar

front 6

What is phosphorolysis?

back 6

Using a phosphate to break a bond

front 7

This enzyme cleaves an alpha (1->4) linkage from nonreducing ends. Product is a glucose 1-phosphate

back 7

Glycogen phosphorylase

front 8

What is the difference between Phosphatase and Phosphorylase?

back 8

Phosphatase removes the Phosphate

Phosphorylase uses phosphate to cleave a bond

front 9

This enzyme removes G1P until 3-4 residues away from an alpha (1->6) branch point.

back 9

Glycogen phosphorylase

front 10

Describe the steps of the debranching enzyme

back 10

-A transferase transfers the last 3 residues to the nonreducing end of the longer chain

-A glucosidase hydrolyzes an alpha(1->6) linkage to cleave off the glucose

front 11

This enzyme catalyzes a reversible isomerization from G1P to G6P

back 11

Phosphoglucomutase

front 12

What happens when there is lots of glucose and ATP?

back 12

Glycogen Synthesis

front 13

What are the steps to Glycogen Synthesis

back 13

Phosphoglucomutase (Activation), Glycogen synthase (Elongation), Glycogen branching enzyme (Branching),

front 14

What is Glycogenin?

back 14

A protein with Tyrosine residue which adds the Tyr, adds 6-7 more UDP glucose and adds branching

front 15

Name the regulation when one pathway is on while the opposite is off

back 15

Reciprocal regulation

front 16

Which regulation has G6P determine what is on and off

back 16

Allosteric Regulation

front 17

In covalent modification...

back 17

Phosphorylation of glycogen phosphorylase: on

Phosphorylation of glycogen synthase: off

front 18

Glycogen Phosphorylase is in the R state when Glycogen Phosphorylase is _____

back 18

On

front 19

What hormones do Glycogen Phosphorylase activate?

back 19

Glucagon and Epinephrine

front 20

Explain the different types of Muscle fibers

back 20

Slow twitch muscles are good for endurance while fast twitch muscles are good for sprinting short distances. Can be tested by just running and seeing how you feel