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Immunobio test 1 lecture 8

front 1

2/13

Types of humoral immune responses and functional diversificiation of antibodies

back 1

no data

front 2

  1. review of
    • B cell functions
    • antibody functions
  2. allergy
  3. primary immunodeficiency diseases

back 2

this lecture

front 3

B cells process protein Ags and display them in the context of MHC II molecules to T cells

back 3

endocytosis of extracellular protein (takes it into MHC cell -> process it -> present peptide to T cell)

MAH class II: CD4 T cell

remember that when antigen 1st encounter - typically grabbed by antigen presenting cells, lie dendritic cells

load on MHC molecule -> specific for T cell -> present to T cell

this happens in B cells too

front 4

B cells present antigen (APCs) to T cells (Tfh) in the GCs

back 4

B cell recognition of native protein antigen

-> receptor mediated endocytosis of antigen

-> antigen processing and presentation

-> T cell recognition of antigen

B cells can see antigen independently,

Can internalize it, and activate T cell

front 5

B cells are antigen presenting cells

back 5

Interaction is only mechanism for antigen presentation to T cells during geminal center reaction

B cells are very good antigen presenting cells, and their presenting capability is required for last step in immune response, where B cells are left to interact for T cell immune responses

front 6

which immune cells present antigen to T cells during a T cell dependent Ab response?

back 6

pause for activity

  1. dendritic cells - present antigen to initiate T activation
  2. B cells - present antigen to already activated T cells

front 7

Ig heavy chain class (isotype) switching

back 7

went over this before

front 8

allergies

back 8

when the immune system attacks non-threatening substances

front 9

molecules involved in allergic reactions

back 9

IgE

  • antigen binding sites in IgE antibody
  • antibody constant region binds Fc receptors (FcRs) on innate cells
  • FceR bind to the constant region of IgE. FceR receptors are present on mast cells

front 10

what antibody is the main receptor involved in allergic reactions?

back 10

IgE