front 1 What is the minimum ISO requirement for an anteroom that is attached to a positive-pressure buffer room? | back 1 ISO 8 The minimum air quality requirement in the anteroom would be ISO 8 if it opens into a positive-pressure buffer area. An ISO rating that has a number lower than 8 (e.g., ISO 7) would mean the air is even cleaner and would therefore also be acceptable, but is not required. |
front 2 For a compounder to pass the media-fill test, how long must the sample remain free from turbidity? | back 2 14 days Turbidity on or before day 14 indicates that contamination is present. If the liquid stays clear after 14 days of incubation, the compounder passed the test. |
front 3 Which of the following areas requires at least 30 air changes per hour (ACPH)? | back 3 The buffer room used to prepare sterile hazardous drugs |
front 4 How often should the pharmacist-in-charge perform a wipe sampling to determine the amount of hazardous drug residue in the class II biological safety cabinet? | back 4 Every 6 months |
front 5 Which of the following practices help prevent contamination of compounded sterile products when working in a primary engineering control (PEC)? (Select ALL that apply.) | back 5 Keep needles and injection ports in the first air Compound at least six inches inside the PEC Do not block the HEPA filter with hands or supplies |
front 6 A type of primary engineering control (PEC) which requires materials to be passed through a chamber into an enclosed working area that is accessed through glove ports is called a: | back 6 Compounding aseptic isolator |
front 7 During a 12-hour work shift preparing intravenous chemotherapy (assuming no breaks), what is the minimum number of times that the gloves will need to be changed during the shift after donning the first pair? | back 7 23 |
front 8 A pharmacy manager is taking an inventory of the sterile compounding area garbing supplies and finds some garb that should not be worn in the sterile compounding area. According to USP 797, all of the following items can be worn in the cleanroom EXCEPT: | back 8 Powdered gloves |
front 9 The surfaces of the laminar airflow workbench should be disinfected with: | back 9 70% isopropyl alcohol |
front 10 If a compounded sterile product is prepared in a compounding aseptic isolator that is located in a segregated compounding area, what is the maximum beyond-use date that can be assigned? | back 10 12 hours The beyond-use date designated by USP for a sterile product compounded in a glove box located in an SCA is no more than 12 hours. |
front 11 Which of the following is an acceptable alternative to an external exhaust when compounding non-sterile hazardous drugs? | back 11 Redundant HEPA filters |
front 12 What is the name of the organization that determines which drugs are hazardous? | back 12 The National Institute for Occupational Safety and Health |
front 13 A hospital pharmacy has the following layout for their sterile compounding area. What is the minimum ISO requirement for the ante room? **Picture** | back 13 ISO 8 |
front 14 Use: Cyclophosphamide oral liquid is used in the treatment of many adult and pediatric malignancies. Packaging: Package in tight, light-resistant containers. Labeling: Keep out of the reach of children. Shake well. Store in a refrigerator. Discard after 56 days. Stability: A beyond-use date of 56 days can be used for this preparation only when it is stored in a refrigerator. The reported stability study used the injection as the source of the drug. Which of the following is a requirement for gloves while preparing this compound? (Select ALL that apply) | back 14 Gloves must be changed every 30 mins while compounding Two pairs of ASTM-rated gloves are required Gloves worn must be powder-free |
front 15 Use: Cyclophosphamide oral liquid is used in the treatment of many adult and pediatric malignancies. Packaging: Package in tight, light-resistant containers. Labeling: Keep out of the reach of children. Shake well. Store in a refrigerator. Discard after 56 days. Stability: A beyond-use date of 56 days can be used for this preparation only when it is stored in a refrigerator. The reported stability study used the injection as the source of the drug. The workbench used to prepare this compound has which of the following characteristics? (Select ALL that apply) | back 15 Negative pressure airflow to protect the personnel compounding the product Airflow is vented to the outside of the building |
front 16 Use: Cyclophosphamide oral liquid is used in the treatment of many adult and pediatric malignancies. Packaging: Package in tight, light-resistant containers. Labeling: Keep out of the reach of children. Shake well. Store in a refrigerator. Discard after 56 days. Stability: A beyond-use date of 56 days can be used for this preparation only when it is stored in a refrigerator. The reported stability study used the injection as the source of the drug. If the space used to prepare this compound is also used to prepare sterile compounded products, what is the required air quality for the buffer room? | back 16 ISO 7 |
front 17 Where do the pharmacy personnel don garb for sterile compounding? | back 17 Anteroom Handwashing, garbing, CSP labeling and other procedures that release a high amount of particulates are done in the anteroom. |
front 18 A pharmacist intern will be reconstituting ifosfamide powder with sterile water for injection and further diluting it with normal saline. Two pairs of each of the following garb are required for this activity: (Select ALL that apply.) | back 18 Shoe covers Chemotherapy gloves (Ifosfamide is an intravenous chemotherapy drug. Healthcare workers must wear a head cover, a face mask, two pairs of shoe covers, a chemotherapy gown and two pairs of chemotherapy gloves when compounding sterile HDs.) |
front 19 Carmustine vials must be stored at 2°C to 8°C (36°F to 46°F). Where can the carmustine vials be stored? | back 19 In a dedicated refrigerator that only contains antineoplastic drugs. The refrigerator is located in the negative pressure buffer room |
front 20 A hospital pharmacy director is designing a new compounding cleanroom for preparing sterile and non-sterile hazardous drugs (HDs) within the same buffer room. Which of the following plans for containment primary engineering controls (C-PECs) is compliant with USP standards? | back 20 Two C-PECs, each dedicated for either sterile or non-sterile products, separated by at least 1 meter |
front 21 Which of the following garb can be retained in the anteroom for reuse on the same shift when making non-hazardous compounded sterile products? | back 21 Gown |
front 22 A drug wholesaler delivers a plastic tote containing chemotherapy drugs to the pharmacy. Upon opening the tote, the technician discovers that the drugs are not wrapped in plastic. What personal protective equipment should the technician wear when unpacking this tote? | back 22 An elastomeric half-mask with a multi-gas cartridge and P100-filter |
front 23 Which of the following are acceptable reasons to compound a drug product for a patient? (Select ALL that apply.) | back 23 The patient needs a drug in a formulation that is not commercially available There is currently a shortage of the commercially available product The patient is allergic to preservatives, dyes or other inactive ingredients in the commercially available product The patient needs a drug strength that is not commercially available |
front 24 A technician will be cleaning underneath the work surface of a biological safety cabinet used for compounding chemotherapy. According to USP 800, which respirator is appropriate for this activity? | back 24 Powered air-purifying respirator |
front 25 A pharmacist working in an Oncology Infusion Center is responsible for the sterile preparation of chemotherapy drugs. All of the following resources would be useful to educate the pharmacist regarding standard work practices EXCEPT: | back 25 USP Chapter 795 |
front 26 The pharmacy manager of a sterile compounding pharmacy wants to ensure that she is maintaining a clean environment. Which of the following is required to ensure a sterile environment? (Select ALL that apply.) | back 26 Air sampling Surface sampling Staff members must pass a gloved fingertip test |
front 27 A pharmacist will be checking a batch of IV admixtures inside of the buffer room. The director of pharmacy notices that the pharmacist is wearing makeup. What is the most appropriate action for the director of pharmacy to take? | back 27 The pharmacist must remove her makeup before entering the anteroom |
front 28 The temperature range for refrigerators used to store drug products should remain between 2 and 8 oC. The freezer temperature should remain within the range of -25 to -10 oC when storing only compounded products. **Picture** | back 28 Reviewing the temperature log provided, the refrigerator temperature was out of range on Days 3 and 6. The freezer temperature was out of range on Days 4 and 6. |
front 29 A pharmacy technician will prepare Zosyn 4.5 grams in 100 mL NS for a hospital patient. The supervising staff pharmacist is concerned because the technician is not following the hospital's policies and procedures for preparing sterile compounded preparations. Which of the following can be used to evaluate the technician's aseptic technique? | back 29 Media-fill test |
front 30 During a 12-hour work shift preparing intravenous chemotherapy (assuming no breaks), what is the minimum number of gowns that will be needed for the entire shift assuming that no additional manufacturer information is available? | back 30 4 Gowns must be changed per the manufacturer’s schedule. If no information is provided, gowns should be changed every 2–3 hours and immediately after a spill or splash. Since the shift is 12 hours and the gown must be changed at least every 3 hours, a minimum of 4 gowns will be needed during the shift. |
front 31 Which of the following is recommended when compounding to contain hazardous drugs and prevent spills? | back 31 Closed-system transfer devices (CSTDs) |
front 32 After an eye exposure to a drug or chemical, what is the minimum number of minutes that the eye/s should be flushed out in the eyewash station? | back 32 15 mins |
front 33 Which of the following drugs can a hospital pharmacist transport to a nurses' station through the pneumatic tube delivery system? | back 33 Finasteride (Pneumatic tubes must not be used to transport any liquid HDs or any chemotherapy drugs because of the potential for breakage and contamination.) |
front 34 A hazardous drug spill kit should contain each of the following items EXCEPT: | back 34 Brooms and dustpan to get spill waste into HD waste bag |
front 35
Master Formulation Record Ingredients: Quantity Atenolol 100 mg5 tabletsGlycerin USP5 mLOra-Sweet sugar-freeqs ad 250 mL
Storage: At what temperature should the suspension be stored? | back 35 36 to 46o Fahrenheit The master formula record indicates that the suspension must be stored in the refrigerator, which should be 36 to 46o Fahrenheit (2 to 8o Celsius). |
front 36 An oncology nurse accidentally drops a vial of reconstituted carmustine solution, resulting in a large spill on the floor. Which of the following products can be used to decontaminate the area? | back 36 Sodium hypochlorite (bleach) |
front 37 A technician spills an oral rinse containing misoprostol while compounding. Which resource will provide the technician with detailed information on the steps required to manage the exposure? | back 37 The Safety Data Sheet (SDS) |
front 38 The pharmacy technician will sanitize the class II biological safety cabinet used for preparing sterile hazardous drugs. Which of the following statements is correct? | back 38 Peroxide-containing agents can be used to both deactivate and decontaminate surfaces |
front 39 Which of the following preparations require sterile compounding? (Select ALL that apply.) | back 39 Parenteral nutrition Bladder irrigations Radiopharmaceuticals Eye drops |
front 40 What is the most common source of contamination in a sterile compounding environment? | back 40 Compounding personnel |
front 41 A specialty oncology pharmacy has several rooms in the compounding suite. In one room, a technician is preparing a blinatumomab IV admixture for infusion. In another room, a technician is crushing mercaptopurine tablets to compound a 50 mg/mL oral suspension. Which USP standards apply to both of these activities? | back 41 USP 800 |
front 42 A patient arrives at the pharmacy to pick up his medication. The technician notices that the patient's medication is Augmentin. Augmentin must be reconstituted before it is dispensed to the patient. What category of non-sterile compounding is this considered? | back 42 Simple Simple compounding involves reconstituting (“manipulating”) a commercial product by adding one or more ingredients (such as water or alcohol), as directed by the manufacturer. |
front 43
Home Medications
Which of the following medications requires healthcare staff to wear gloves during handling, administration and disposal? | back 43 Methotrexate |
front 44 Which agent is used to clean sterile hoods and gloved hands during compounding? | back 44 70% isopropyl alcohol (IPA) is used to clean the sterile hood and is applied to gloved hands routinely during compounding; contamination from the compounding staff is the top source of contamination and this helps reduce the risk. |