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16 notecards = 4 pages (4 cards per page)

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Pharmacology Drugs for TB

front 1

What bacteria causes TB?

back 1

myclobacterium TB

front 2

What is TB considered?

back 2

"acid fast"

front 3

How many stages of TB are there? Describe them.

back 3

  1. Transmission - Infected
  2. Primary infection - pt has pneumonia like symptoms that eventually go away
  3. Latent infection - bacteria hibernates and chills for a while
  4. Active TB - severe TB symptoms

front 4

List some signs and symptoms of TB.

back 4

low grade fever, weight loss, cough, fatigue, night sweats, coughing up blood (haemoptysis)

front 5

What are the drugs used to treat TB?

back 5

Rifampin, isoniazid, pyrazinamide, ethambutol (RIPE)

front 6

What is the prototype drug for rifamycin?

back 6

rifampin

front 7

How does rifampin work?

back 7

by inhibiting RNA synthesis

front 8

How would we use rifampin?

back 8

alone for latent TB, in combination with other TB drugs for active TB

front 9

What is rifampin's spectrum of activity?

back 9

broad but ONLY for TB

front 10

What are some nursing considerations for rifampin?

back 10

it can cause hepatotoxicity, renal failure, red/orange body fluids, is a BIG enzyme inducer (CYP450) (it will increase the metabolism of many other drugs)

front 11

What does isoniazid do?

back 11

inhibits bacterial CW formation

front 12

How would we use isoniazid?

back 12

alone, but ALWAYS in combination with other TB drugs for active TB.

front 13

What is isoniazid's spectrum of activity?

back 13

selective for mycobacteria

front 14

What are some nursing considerations for isoniazid?

back 14

it's hepatotoxic (can cause jaundice) and peripheral neuropathy. Do liver function tests and to counter peripheral neuropathy, use pyridoxine (vitamin B6).

front 15

What is a possible side effect of pyrazinamide?

back 15

hepatotoxicity

front 16

What is a possible side effect of ethambutol?

back 16

optic neuritis