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The Respiratory System Ch. 22 Module 2: Section 22.03-22.05 Dynamic Study Module
front 1 Match the following: Pleurisy.
| back 1 Inflammation of the serous membranes or serosa surrounding the lungs Ex. Pleurisy (ploo’rĭ-se), inflammation of the pleurae, in flammation of the serous membranes or serosa surrounding the lungs. Inflamed pleurae become rough, resulting in friction and stabbing pain with each breath. As the disease progresses, the pleurae may produce excessive amounts of fluid. This increased fluid relieves the pain caused by pleural surfaces rubbing together, but may exert pressure on the lungs and hinder breathing movements. Other fluids that may accumulate in the pleural cavity include blood (leaked from damaged blood vessels) and blood filtrate (the watery fluid that oozes from the lung capillaries when leftsided heart failure occurs). The term for fluid accumulation in the pleural cavity is pleural effusion. Collapse of the alveoli due to a decreased amount of surfactant can cause infant respiratory distress syndrome. Asthma can result in a strong enough constriction of the bronchioles that air flow is dramatically reduced. Decreased natural resilience of the lungs results in a decrease in lung compliance, requiring more energy to breathe. |
front 2 Match the following term with its correct description: External respiration.
| back 2 Movement of oxygen from the lungs to the blood, and of carbon dioxide from the blood to the lungs Ex. External respiration is the movement of oxygen from the lungs to the blood, and of carbon dioxide from the blood to the lungs. Pulmonary ventilation causes movement of air into and out of the lungs so that gases are continuously changed and refreshed. Pulmonary ventilation, consisting of inspiration and expiration, is a mechanical process that depends on volume changes in the thoracic cavity. A rule to keep in mind is that volume changes lead to pressure changes, and pressure changes lead to the flow of gases to equalize the pressure. Transport of oxygen from lungs to body cells and carbon dioxide from tissue cells to lungs is a transport function of the cardiovascular system. Movement of oxygen from the blood to tissue cells, and of carbon dioxide from tissue cells to blood is internal respiration. The fairly rigid conduits for air to reach the gas exchange sites in the lungs are the respiratory passages that are part of the conducting zone. |
front 3  What value(s) would be affected by a restrictive disorder?
| back 3  VC, TLC, FRC, and RV decline Ex. In restrictive diseases, VC, TLC, FRC, and RV decline because lung expansion is limited, whereas in obstructive diseases, TLC, FRC, and RV may increase because the lungs hyperinflate. |
front 4 Match the following gas law to the appropriate respiratory event: Boyle's law.
| back 4 Pressure and volume have an inverse relationship. Inspiration increases lung volume by enlarging all of its dimensions; this lowers gas pressure inside the lungs. Ex. Boyles law describes how pressure and volume have an inverse relationship. Inspiration increases lung volume by enlarging all of its dimensions; this lowers gas pressure inside the lungs. Boyle’s law gives the relationship between the pressure and volume of a gas: At constant temperature, the pressure of a gas varies inversely with its volume. That is, P1V1 = P2V2 where P is the pressure of the gas, V is its volume, and subscripts 1 and 2 represent the initial and resulting conditions, respectively. Gases always fill their container. Consequently, in a large container, the molecules in a given amount of gas will be far apart and the pressure will be low. But if the volume of the container is reduced, the gas molecules will be forced closer together and the pressure will rise. A good example is an inflated automobile tire. The tire is hard and strong enough to bear the weight of a car because air is compressed to about one-third of its atmospheric volume inside the tire, providing high pressure. Partial pressures of a gas are defined by Dalton’s law, which states that the total pressure exerted by a mixture of gases is the sum of the pressures exerted independently by each gas in the mixture. The amount of gas dissolved in solution is given by Henry’s law, which states that when a gas is in contact with a liquid, the gas will dissolve in the liquid in proportion to its partial pressure. The more a lung expands for a given rise in transpulmonary pressure, the greater its compliance is the relationship called lung compliance. |
front 5 Match the following term with its correct description: Pulmonary ventilation.
| back 5 Movement of air into and out of the lungs so that gases are continuously changed and refreshed Ex. Pulmonary ventilation causes movement of air into and out of the lungs so that gases are continuously changed and refreshed. Pulmonary ventilation (commonly called breathing): Air is moved into and out of the lungs (during inspiration and expiration) so the gases there are continuously changed and refreshed. Pulmonary ventilation, consisting of inspiration and expiration, is a mechanical process that depends on volume changes in the thoracic cavity. A rule to keep in mind is that volume changes lead to pressure changes, and pressure changes lead to the flow of gases to equalize the pressure. Transport of oxygen from lungs to body cells and carbon dioxide from tissue cells to lungs is a transport function of the cardiovascular system. Movement of oxygen from the blood to tissue cells, and of carbon dioxide from tissue cells to blood is internal respiration. The fairly rigid conduits for air to reach the gas exchange sites in the lungs are the respiratory passages that are part of the conducting zone. |
front 6  Match the following: “A.”
| back 6 Amount of air inhaled or exhaled with each breath under resting conditions Ex. “A” represents tidal volume, the amount of air inhaled or exhaled with each breath under resting conditions. |
front 7 Match the following volume or capacity to its correct description: Vital capacity.
| back 7 Maximum volume of air that can be exhaled after maximum inhalation Ex. Vital capacity is the maximum volume of air that can be exhaled after maximum inhalation. The respiratory capacities include inspiratory, functional residual, vital, and total lung capacities. The respiratory capacities always consist of two or more lung volumes.
The maximum amount of air that can be inhaled after a normal inspiration is the inspiratory reserve volume. 6000 ml is the typical total lung volume in an average adult male. |
front 8 In the alveoli, the partial pressure of oxygen is __________.
| back 8  about 104 mm Hg Ex. In the alveoli, the partial pressure of oxygen is about 104 mm Hg. Partial pressure gradients of O2 and CO2 drive the diffusion of these gases across the respiratory membrane. A steep oxygen partial pressure gradient exists across the respiratory membrane because the PO2 of deoxygenated blood in the pulmonary arteries is only 40 mm Hg, as opposed to a PO2 of approximately 104 mm Hg in the alveoli. As a result, O2 diffuses rapidly from the alveoli into the pulmonary capillary blood. |
front 9 The movement of air into and out of the lungs is called __________.
| back 9 pulmonary ventilation Ex. The movement of air into and out of the lungs is called pulmonary ventilation. Pulmonary ventilation, consisting of inspiration and expiration, is a mechanical process that depends on volume changes in the thoracic cavity. A rule to keep in mind is that volume changes lead to pressure changes, and pressure changes lead to the flow of gases to equalize the pressure. During external respiration oxygen diffuses from the lungs to the blood, and carbon dioxide diffuses from the blood to the lungs. During internal respiration oxygen diffuses from blood to tissue cells, and carbon dioxide diffuses from tissue cells to blood. Oxidative phosphorylation is used during the process of cellular respiration to produce ATP within the mitochondria. |
front 10 What value(s) would be affected by an obstructive disorder?
| back 10 TLC, FRC, and RV may increase Ex. In obstructive diseases, TLC, FRC, and RV may increase because the lungs hyperinflate, whereas in restrictive diseases, VC, TLC, FRC, and RV decline because lung expansion is limited. |
front 11 Air moves into the lungs because __________.
| back 11  the gas pressure in the lungs becomes lower than the outside pressure as the diaphragm contracts Ex. Air moves into the lungs because the gas pressure in the lungs becomes lower than the outside pressure as the diaphragm contracts. As the thoracic dimensions increase during inspiration, the lungs are stretched and the intrapulmonary volume increases. As a result, Ppul drops about 1 mm Hg relative to Patm. Anytime the intrapulmonary pressure is less than the atmospheric pressure (Ppul < Patm), air rushes into the lungs along the pressure gradient. Inspiration ends when Ppul = Patm. During the same period, Pip declines to about −6 mm Hg relative to Patm. |
front 12 Which of the following is false?
| back 12 Minute ventilation values are the best way to assess respiratory efficiency. Ex. It would be false to say that minute ventilation values are the best way to assess respiratory efficiency. The minute ventilation is the total amount of gas that flows into or out of the respiratory tract in 1 minute. During normal quiet breathing, the minute ventilation in healthy people is about 6 L/min (500 ml per breath multiplied by 12 breaths per minute). During vigorous exercise, the minute ventilation may reach 200 L/min. Minute ventilation values provide a rough yardstick for assessing respiratory efficiency, but the alveolar ventilation rate (AVR) is a better index of effective ventilation. The AVR takes into account the volume of air wasted in the dead space and measures the flow of fresh gases in and out of the alveoli during a particular time interval. We can compute AVR using this equation: AVR = frequency × (TV − dead space) (ml/min) (breaths/min) (ml/breath) In healthy people, AVR is usually about 12 breaths per minute times the difference of 500 − 150 ml per breath, or 4200 ml/min. Because anatomical dead space is constant in a particular individual, increasing the volume of each inspiration (breathing depth) enhances AVR and gas exchange more than raising the respiratory rate. AVR drops dramatically during rapid shallow breathing because most of the inspired air never reaches the exchange sites. Furthermore, as tidal volume approaches the dead space value, effective ventilation approaches zero, regardless of how fast a person is breathing. |
front 13 Match the following volume or capacity to its correct description: Tidal volume.
| back 13 About 500 ml Ex. Tidal volume is about 500 ml. The respiratory capacities include inspiratory, functional residual, vital, and total lung capacities. The respiratory capacities always consist of two or more lung volumes.
6000 ml is the typical total lung capacity for an average adult male. |
front 14 Which of the following movements would not ventilate the alveoli?
| back 14 Burping Ex. Burping does not ventilate the alveoli. Many processes other than breathing move air into or out of the lungs, altering the normal respiratory rhythm. These non-respiratory air movements occur whenever you cough, sneeze, cry, laugh, hiccup, or yawn. Some can be produced voluntarily, but some (such as sneezing and hiccups) are reflexive. |
front 15 Which respiratory measurement is normally the greatest?
| back 15 Vital capacity Ex. Vital capacity is the greatest of the volumes given. The respiratory capacities include inspiratory, functional residual, vital, and total lung capacities. The respiratory capacities always consist of two or more lung volumes.
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front 16 The transpulmonary pressure is the difference between the __________ and the __________ pressure.
| back 16  intrapulmonary; intrapleural Ex. The transpulmonary pressure is the difference between the intrapulmonary and intrapleural pressures (Ppul – Pip). It is this pressure that keeps the air spaces of the lungs open or, phrased another way, keeps the lungs from collapsing. Moreover, the size of the transpulmonary pressure determines the size of the lungs at any time—the greater the transpulmonary pressure, the larger the lungs. We cannot overemphasize the importance of negative pressure in the intrapleural space and the tight coupling of the lungs to the thorax wall. Any condition that equalizes Pip with the intrapulmonary (or atmospheric) pressure causes immediate lung collapse. |
front 17 Match the following: “F.”
| back 17 Maximum amount of air contained in lungs after a maximum inspiratory effort Ex. “F” represents total lung capacity, the maximum amount of air contained in lungs after a maximum inspiratory effort. |
front 18 FEV1 can be used to diagnose what condition?
| back 18 Obstructive pulmonary disorders Ex. FEV1 can be used to diagnose obstructive pulmonary disorders. The volume exhaled during the first second is FEV1. Those with healthy lungs can exhale about 80% of the forced vital capacity (FVC) within 1 second. Those with obstructive pulmonary disease exhale considerably less than 80% of the FVC within 1 second, while those with restrictive disease can exhale 80% or more of FVC in 1 second even though their FVC is reduced. |
front 19 Which of the following conditions would not cause atelectasis?
| back 19  Increased atmospheric pressure Ex. Increased atmospheric pressure would not cause atelectasis. Atelectasis (at”ĕ-lik’tah-sis), or lung collapse, occurs when a bronchiole becomes plugged (as may follow pneumonia). Its associated alveoli then absorb all of their air and collapse. Atelectasis can also occur when air enters the pleural cavity either through a chest wound or a rupture of the visceral pleura, which allows air from the respiratory tract to enter the pleural cavity. The presence of air in the pleural cavity is referred to as a pneumothorax (nu”mo-tho’raks; “air thorax”), and is reversed by drawing air out of the intrapleural space with chest tubes. This procedure allows the pleurae to heal and the lung to re-inflate and resume normal function. |
front 20 Match the following: “D.”
| back 20 Volume of air remaining in the lungs after a normal tidal volume expiration Ex. “D” represents functional residual capacity, the volume of air remaining in the lungs after a normal tidal volume expiration. |
front 21 Match the following: “C.”
| back 21 Maximum amount of air that can be inspired after a normal tidal volume expiration Ex. “C” represents inspiratory capacity, the maximum amount of air that can be inspired after a normal tidal volume expiration. |
front 22 Match the following volume or capacity to its correct description: Total lung capacity.
| back 22 About 6000 ml in an average male Ex. Total lung capacity is about 6000 ml in an average male. The respiratory capacities include inspiratory, functional residual, vital, and total lung capacities. The respiratory capacities always consist of two or more lung volumes.
The maximum amount of air that can be inhaled after a normal inspiration is the inspiratory reserve volume. 500 ml is the typical tidal volume. |
front 23 Match the following: “B.”
| back 23 Amount of air remaining in the lungs after a forced expiration Ex. “B” represents residual volume, the amount of air remaining in the lungs after a forced expiration. |
front 24 Match the following: IRDS.
| back 24 Collapse of alveoli due to little surfactant Ex. IRDS, Infant Resiratory Distress Syndrome, is collapse of alveoli due to little surfactant. When too little surfactant is present, surface tension can collapse the alveoli. Once this happens, the alveoli must be completely reinflated during each inspiration, an effort that uses tremendous amounts of energy. This is the problem faced by newborns with infant respiratory distress syndrome (IRDS), a condition common in premature babies. Since fetal lungs do not produce adequate amounts of surfactant until the last two months of development, babies born prematurely often are unable to keep their alveoli inflated between breaths. IRDS is treated by spraying natural or synthetic surfactant into the newborn’s respiratory passageways. In addition, devices that maintain positive airway pressure throughout the respiratory cycle can keep the alveoli open between breaths. Severe cases require mechanical ventilators. Many IRDS survivors suffer from bronchopulmonary dysplasia, a chronic lung disease, during childhood and beyond. This condition is believed to result from inflammatory injury caused by mechanically ventilating the premature newborn’s delicate respiratory zone structures. Inflammation of the pleurae, called pleurisy, often results from pneumonia. Asthma can result in a strong enough constriction of the bronchioles that air flow is dramatically reduced. |
front 25 __________ pressure keeps the air spaces in the lung open.
| back 25 Transpulmonary pressure Ex. Transpulmonary pressure keeps the air spaces in the lung open. The transpulmonary pressure is the difference between the intrapulmonary and intrapleural pressures (Ppul – Pip). It is this pressure that keeps the air spaces of the lungs open or, phrased another way, keeps the lungs from collapsing. Moreover, the size of the transpulmonary pressure determines the size of the lungs at any time—the greater the transpulmonary pressure, the larger the lungs. We cannot overemphasize the importance of negative pressure in the intrapleural space and the tight coupling of the lungs to the thorax wall. Any condition that equalizes Pip with the intrapulmonary (or atmospheric) pressure causes immediate lung collapse. Intrapulmonary pressure is the pressure inside the lung. |
front 26 Match the following: Asthma.
| back 26 Such strong bronchoconstriction that pulmonary ventilation almost completely stops, regardless of the pressure gradient Ex. Asthma causes such strong bronchoconstriction that pulmonary ventilation almost completely stops, regardless of the pressure gradient. Smooth muscle of the bronchiolar walls is exquisitely sensitive to neural controls and certain chemicals. For example, inhaled irritants activate a reflex of the parasympathetic division of the nervous system that causes vigorous constriction of the bronchioles and dramatically reduces air passage diameters. During an acute asthma attack, histamine and other inflammatory chemicals can cause such strong bronchoconstriction that pulmonary ventilation almost completely stops, regardless of the pressure gradient. Conversely, epinephrine released during sympathetic nervous system activation or administered as a drug dilates bronchioles and reduces airway resistance. Local accumulations of mucus, infectious material, or solid tumors in the passageways are important sources of airway resistance in those with respiratory disease. Whenever airway resistance rises, breathing movements become more strenuous, but such compensation has its limits. When the bronchioles are severely constricted or obstructed, even the most extreme respiratory efforts cannot restore ventilation to life-sustaining levels. Collapse of the alveoli due to decreased surfactant occurs in infant respiratory distress syndrome. Pleurisy, inflammation of the pleurae, often results from pneumonia. Collapse of the lungs due to plugged bronchioles is called atelectasis. |
front 27 Match the following: “E.”
| back 27 Maximum amount of air that can be expired after a maximum inspiratory effort Ex. “E” represents vital capacity, the maximum amount of air that can be expired after a maximum inspiratory effort. |