front 1 A health care professional is caring for a patient who is about to begin taking mercaptopurine (purinethol) to treat leukemia. Which of the following instructions should the health care professional include when talking with the patient about the drug? | back 1
Use contraception if pregnancy is a risk is correct.
Mercaptopurine, a purine analog, is a pregnancy risk category D drug.
Women of childbearing age who take the drug should use contraception,
and the health care professional should confirm non-pregnancy before
starting therapy. |
front 2 A health care professional is caring for a patient who is about to begin receiving cisplatin to treat testicular cancer. The health care professional should tell the patient to report which of the following adverse effects? | back 2
Paresthesias is correct. Cisplatin, a platinum
compound, can cause peripheral neuropathy. The health care
professional should tell the patient to report numbness, tingling, or
decreased sensation in the hands or feet. |
front 3 While assessing a patient who is receiving interferon alfa-2a (Roferon-A) to treat Kaposi's sarcoma, the health care professional should check for which of the following possible indications of an adverse reaction? Bradycardia Dilated pupils Fever Constipation | back 3 Fever Interferon alfa-2a, a biologic-response modifier, can cause a flu-like reaction, manifesting as fever, myalgia, and fatigue. For this effect, the health care professional should give the patient acetaminophen (Tylenol). |
front 4 A health care professional should understand that enfuvirtide (Fuzeon) is an appropriate choice for patients who have which of the following? Advanced prostate cancer Primary brain tumors Advanced HIV disease Metastatic ovarian cancer | back 4 Advanced HIV disease Enfuvirtide, a fusion inhibitor, treats HIV disease that is advanced or resistant to other types of treatment. Health care professionals should always give the drug along with other antiretroviral drugs. |
front 5 A health care professional is caring for a patient who is receiving IV carmustine (BiCNU) to treat multiple myeloma. The health care professional should recognize that the patient is at the greatest risk for infection for which of the following lengths of time after the infusion? 24hr 1wk 2wks 4-6 wks | back 5 4 to 6 weeks Carmustine, a nitrosourea drug, can cause delayed bone marrow suppression. Thrombocytes and leukocytes reach nadirs at 4 to 6 weeks following IV infusion. The patient should use hand hygiene often and wash fruits and vegetables thoroughly. It is crucial to avoid contact with crowds and people who have communicable infections. |
front 6 A health care professional is caring for a patient who is about to begin intrathecal cytarabine (DepoCyt) therapy to treat meningeal leukemia. The health care professional should explain that the patient should also receive which of the following drugs to reduce the risk of neurotoxicity? Diphenhydramine Leucovorin Folic acid Dexamethasone | back 6 Dexamethasone With the intrathecal form of cytarabine, the patient should also receive dexamethasone, a glucocorticoid, to help decrease the inflammation of the arachnoid that the drug can cause. IV dexamethasone reduces the patient’s risk for neurotoxicity. |
front 7 A health care professional is caring for a patient who is about to begin taking tamoxifen (soltamox) to treat breast cancer. The health care professional should recognize the need for cautious use of the drug if the patient also has which of the following? Cataracts COPD Diabetes mellitus Alcohol use disorder | back 7 Cataracts Tamoxifen, an estrogen-receptor blocker, can cause retinopathy, cataracts, and decreased visual acuity. Its use requires caution with patients who already have cataracts. |
front 8 When talking to a patient who is about to begin vincristine therapy to treat lymphoma, the health care professional should include which of the following instructions? Increase fiber intake. Report tinnitus or vertigo. Take the drug with 8 oz of water. Allow 4 hr before taking an antacid. | back 8 Increase fiber intake. Vincristine, a vinca alkaloid, can cause severe constipation and upper colon fecal impaction. The health care professional should monitor the patient’s bowel function and palpate the abdomen for distention. The patient should increase fluid and fiber intake, and take stool softeners. |
front 9 A health care professional is caring for a patient who is about to begin taking imatinib (gleevec) to treat chronic myeloid leukemia. Which of the following instructions should the health care professional include when talking to the patient about taking the drug? | back 9
Clean fruits and vegetables thoroughly is correct.
Imatinib, a targeted antineoplastic drug, can cause bone marrow
suppression. The health care professional should tell the patient to
clean fruits and vegetables carefully and completely to prevent
transmission of bacteria. |
front 10 A health care professional is caring for a patient who is about to begin topotecan (Hycamtin) therapy to treat resistant, small-cell lung cancer. The health care professional should caution the patient about taking which of the following types of over-the-counter drugs while receiving the therapy? | back 10 Ibuprofen (Advil) NSAIDs, anticoagulants, and antiplatelet drugs increase the patient’s risk for bleeding while receiving topotecan, a topoisomerase inhibitor. The health care professional should advise the patient against taking aspirin, ibuprofen (Advil), and other NSAIDs during the therapy. |
front 11 health care professional is assessing a patient following a trastuzumab (Herceptin) infusion to treat metastatic breast cancer. Which of the following findings indicates an adverse reaction to the drug? Wheezing Dysrhythmias Hypotension FeverAscites | back 11
Wheezing is correct. Trastuzumab, a monoclonal
antibody, can cause a severe allergic reaction, manifesting as hives,
bronchospasm, dyspnea, and wheezing. The health care professional
should have epinephrine ready to treat anaphylaxis. |
front 12 When talking with a patient who is about to begin methotrexate (trexall) therapy to treat non-Hodgkin lymphoma, the health care professional should include which of the following instructions? Take echinacea supplements. Use a soft-bristled toothbrush. Take aspirin to reduce muscle pain. Urinate every 4 hr. | back 12 Use a soft-bristled toothbrush. Methotrexate, a folic acid antagonist, can cause severe bone marrow suppression with decreased thrombocyte counts and also oral and GI ulceration. Patients should use a soft-bristled toothbrush to prevent gum bleeding and mouth trauma. |
front 13 A health care professional is caring for a patient who is about to start ritonavir (norvir) and zidovudine (retrovir) therapy to treat HIV-1. The health care professional should explain that the patient will receive ritonavir along with at least one reverse transcriptase inhibitor to | back 13 prevent drug resistance. Give zidovudine, a nucleoside reverse transcriptase inhibitor, along with ritonavir, a protease inhibitor, to reduce the risk for drug resistance and to increase drug effectiveness. Monotherapy with zidovudine quickly results in drug resistance, as is also the case with monotherapy with ritonavir. |
front 14 A health care professional should question the use of cyclophosphamide for a patient who has? | back 14 Dehydration Cyclophosphamide, a nitrogen mustard, is contraindicated for patients who have a fluid-volume deficit because dehydration increases the risk for renal toxicity. |
front 15 A health care professional is caring for a patient who is about to begin delavirdine (rescriptor) therapy to treat HIV-1. The health care professional should tell the patient to report which of the following adverse reactions to the drug? Rash, Insomnia, Rhinitis, or Alopecia | back 15 Rash Delavirdine, a non-nucleoside reverse transcriptase inhibitor, can cause a rash. The health care professional should tell the patient to report a rash, which can occur 1 to 3 weeks after therapy, because it can develop into Stevens-Johnson syndrome, a potentially life-threatening complication. |
front 16 When considering drug therapy options for a patient who has metastatic breast cancer that is positive for human epidermal growth factor receptor 2 (HER2), the health care professional should choose which of the following drugs? Trastuzumab (Herceptin)Imatinib (Gleevec)Leuprolide (Lupron)Flutamide | back 16 Trastuzumab (Herceptin) Trastuzumab, a monoclonal antibody and a pregnancy risk category D drug, treats metastatic breast cancer with tumors that over express. This type accounts for up to 30% of metastatic breast tumors. |
front 17 A health care professional should question the use of anastrozole (Arimidex) for a patient who is allergic to salicylates.premenopausal.hearing impaired.immunocompromised. | back 17 premenopausal. Anastrozole, an aromatase inhibitor, treats early or advanced estrogen receptor-positive breast cancer in postmenopausal women. It is contraindicated for women who are premenopausal as well as for women who are postmenopausal but are taking estrogen. Anastrozole stops tumor growth by inhibiting estrogen synthesis. |
front 18 When caring for a patient who is receiving vincristine to treat lung cancer, the health care professional should monitor for which of the following findings that indicates an adverse effect? Weak hand graspsConstricted pupilsBradycardiaCrackles | back 18 Weak hand grasps Vincristine, a vinca alkaloid, can cause peripheral neuropathy. The health care professional should monitor deep-tendon reflexes and the strength and movement of the hands and feet. The health care professional should tell the patient to report paresthesias or reduced sensation in the hands or feet. |
front 19 Unless there are any specific contraindications, which of the following immunizations should adults receive once each year? VaricellaTetanusInfluenzaHepatitis B | back 19 Influenza All adults should receive the seasonal influenza immunization once per year. All children 6 months older and older adults should also receive this immunization once per year. |
front 20 A health care professional should question the use of maraviroc (selzentry) for a patient who has which of the following? Diabetes mellitusMeningeal infectionPancreatitisNon-chemokine receptor 5 (CCR5)-tropic HIV-1 | back 20 Non-chemokine receptor 5 (CCR5)-tropic HIV-1 Maraviroc, a CCR5 antagonist, acts by binding to CCR5 and preventing HIV-1 from entering the cell. It is only effective for patients who have CCR5-tropic HIV-1. It is contraindicated for those who do not have CCR5-tropic HIV-1. |
front 21 A health care professional is about to administer IV paclitaxel (taxol) to a patient who has ovarian cancer. Which of the following actions should the health care professional take? Give the patient an antihistamine.Infuse the drug over 1 hr.Administer the drug through non-PVC tubing.Use an in-line filter.Add heparin to the paclitaxel solution. | back 21
Give the patient an antihistamine is correct. Prior
to administering paclitaxel, an antimitotic drug, the health care
professional should give the patient an antihistamine, such as
diphenhydramine, a proton-pump inhibitor, such as cimetidine
(Tagamet), and a glucocorticoid, such as dexamethasone, to prevent a
hypersensitivity reaction. |
front 22 A health care professional should understand that raltegravir (Isentress) treats patients who have which of the following? Hairy cell leukemiaThyroid cancerKaposi's sarcomaResistant HIV disease | back 22 Resistant HIV disease Raltegravir, an integrase inhibitor, along with other antiretroviral drugs, treats HIV disease that is resistant to other drugs. Health care professionals should always give the drug along with other antiretroviral drugs. |
front 23 A health care professional is caring for a patient who is about to begin maraviroc (selzentry) therapy. The health care professional should tell the patient to report which of the following adverse effects of the drug? ParesthesiasCoughTinnitusJaundiceFever | back 23
Paresthesias is correct. Maraviroc, a chemokine
receptor 5 antagonist, can cause paresthesias, dizziness, and
musculoskeletal pain. |
front 24 When caring for a patient who is taking flutamide to treat prostate cancer, the health care professional should monitor the patient for which of the following adverse effects of the drug? Dehydration Gynecomastia Constipation Tachycardia | back 24 Gynecomastia Flutamide, an androgen receptor blocker, treats early and metastatic prostate cancer. It can cause gynecomastia, or growth of breast tissue, decreased libido, and impotence. |
front 25 A health care professional is about the administer enfuvirtide (Fuzeon) to a patient. The health care professional should perform which of the following actions? Administer the drug subcutaneously.Discard unused portion.Roll the vial gently to reconstitute the solution.Inject the solution at room temperature.Expect a cloudy solution. | back 25
Administer the drug subcutaneously is correct. The
health care professional should administer enfuvirtide, a fusion
inhibitor, subcutaneously, twice a day. This is the only appropriate
route of administration for the drug. |