These have not been graded, if you see an error please let me know which notecard & what page you found the correction on. ~THANK YOU~
These have not been graded, if you see an error please let me know which notecard & what page you found the correction on. ~THANK YOU~
A complete, asembled virus
Virion
pg. 371
The subunits making up the protein outer coating of most viruses.
Capsomere
pg. 371
The protein outer coating of most viruses.
Capsid
A term derived from the word for poison.
Virus
pg. 370
A combination of lipids, proteins, & carbohydrates covering the protein coating of a virus.
Envelope
pg. 371
Infectious prion
PrPsc
pg. 395
Describes the morhology of the capsid of many viruses.
Icosahedral
pg. 373
A method by which a virus enters an animal host cell.
Endocytosis
pg. 385
A cell line derived from tissue that normally reproduces for relatively few generations.
Primary cell line
pg. 379
The HeLa cell line would be placed in this group.
Continous
pg. 380
A clearing in a "lawn" of susceptible bacterial cells.
Plaque
pg. 376
The number of bacteriophages produced by one bacterial host cell.
Burst size
Presumed agent causing diseases such as sheep scrapie.
Prion
pg. 395
A bacterial virus.
Phage
*found in the glossary
A short strand of RNA virus without a capsid.
Viroid
pg. 396
PrP
prion
Describes a method by which an enveloped virus leaves the host cell while acquiring the envelope.
Budding
pg. 392
Describes growth characteristics of normal cell cultures in glass or plastic containers
Monolayer
A term meaning cancer-causing.
Oncogenic
Observable changes in a virus infected cell.
Cytopathic effect
The time during which the capsids & DNA of a phage, already formed, are now assembled into complete viruses.
Maturation period
pg. 383
Cancer of connective tissue
Sarcoma
pg. 392
The clumping of RBC's due to adherence to spikes on viruses.
Hemagglutination
Equivalent to mRNA in a single-stranded RNA viruses.
+ or sense strand
pg. 388
RNA to DNA
Reverse transcription
pg. 390
Varicella virus
Human herpesvirus 3
Herpes simplex 2
Human herpesvirus 2
Epstein-Barr virus
Human herpesvirus 4
Cytomegalovirus
Human herpesvirus 4
Cause of Kaposi's sarcoma
Human herpesvirus 8
The virus, once inside the host cell, seperates the viral nucleic acid from the capsid; this is called _________.
uncoating
pg. 385
Another term for lysogenic phage is __________.
prophage
*see page 383 & 384
_______ are not solid tumors but an excessive production of white blood cells.
Leukcytosis
Many viruses can be grown in ______ eggs.
embryonated
pg. 379
The herpes simplex virus remains_______ in nerve cells or the host for long periods without causing disease.
latent
*got latent from powerpoint slide*
Counts of phage are made in terms of ________ units.
plaque forming
An oncogene might become active when placed on the chromosome in a position where normal controls are not active; this is termed _____________.
unknown
The term _____ refers to the spectrum of host cells the virus can infect.
Host range
pg. 370
When cells multiply in an uncontrolled way, the exess tissue is called a _________.
growth or tumor
Oncogenic viruses are those that __________ cells into tumor cells.
transformed
pg. 393
The type of virus implicated as a cause of AIDS is a(n) _______________.
Retroviridae
(lentivirus= genus)
pg. 390
The abbreviation of TSTA stands for tumor-specific ________ antigens.
transplant
For several minutes following infection by a phage, no complete phages can be found in the host cell; this is called the _____ period.
Eclipse
pg. 383
The ________ of the phage is adsorbed to the host cell.
(ad or absorbed)???
replication
The phage forms a hole in the cell wall using phage _________ & drives the tail core through the cell wall.
Lysozyme
(penetration)
pg. 381
Sometimes the lytic cycle does not occur upon phage infection of a host bacterium. The phage DNA becomes incorporated as a(an)____ into the host's DNA.
lytic
pg. 383
When the phage DNA is incorporated into the host's DNA, this state is called ____________.
Lysogeny (lysogenic cycle)
pg. 383
Transformed cells lose _________; that is, they do not stop reproduction when in contact w/neighbor cells.
unknown
The hepadnavirus has genetic material called ________.
DNA
Picornaviruses have genetic material called _____.
RNA
Tumors are malignant when cancerous & ______ when not cancerous.
benign
14
Invasion or colonization of the body by potentially pathogenic microorganisms.
Infection
14
The cause of a disease.
Etiology
14
A change from a state of health, in which the body is not properly adjusted or capable of performing its normal functions.
Disease
14
The manner in which a disease develops.
Pathogenesis
14
One organism is benefited at the expense of another.
Parasitism
14
The general relationship between the normal microbiota & the host.
Symbiosis
14
One of the organisms is benefited & the other unaffected.
Commensalism
14
A symbiosis that benefits both organisms.
Mutualism
14
Live bacterial cultures intended to exert a beneficial effect.
Probiotics
14
First mild symptoms appear.
Period of incubation
14
The individual regains strength, & the body returns to it prediseased state.
Period of convalescence
14
The time between infection & the first appearance of signs & symptoms.
Prodromal period
14
Easily spread from one person to another person.
Contagious disease
14
Tetanus is an example.
Noncommunicable disease
14
An inanimte object that may transmit disease.
Fomite
14
A group of symptoms associated w/a disease.
Syndrome
14
Identification of a disease.
Diagnosis
14
Objective changes caused by a disease that the physician may observe.
Sign
14
An arthropod, for example, that carries malaria.
Vector
14
A toxic, inflammatory condition arising from spread of bacteria or bacterial toxins from a focus of infection.
Sepsis
14
People who transmit diseases, but who do not exhibit any symtoms of illness.
Carriers
14
A disease that occurs only occasionally.
Sporadic
14
A worlwide epidemic.
Pandemic
14
Diseases acquired in a hospital.
Nosocomial
14
Diseases that occur in animals & can be transmitted to humans.
Zoonoses
14
In ______ transmission of disease, an insect such as a fly carries that pathogen on its body to human food.
mechanical
14
The _____ of a disease is the fraction of the populatio that contracts it during a particular period of time.
incidence
14
____ disease is one that develops rapidly but lasts only a short time.
acute
14
A simple presence of bacteria in the blood is known as __________.
bacteremia
14
A(n) __________ infection is one caused by an opportunist after the primary infection has weakened the body's defenses.
secondary
14
_____ are changes in body function felt by the patient & subjective in nature, such as pain.
Symptom
14
The science that deals w/transmission of diseases in the human population, & when & where they occur, is called _______.
epidemiology
14
The abbreviation CDC stands for ________ & prevention.
Centers for disease control
14
An abscess is an example of a(n) ________ type of infection.
local infection
14
An infection in which the microorganisms or their products are spread through the body in the blood or lymphatic system is known as a(n)________ infection.
Systemic
14
An inapparent, or _____________, disease is one that does not cause any noticable illness.
subclinical
14
The __________ of a disease is the fraction of the population having the disease at a given time.
prevalence
14
Diseases intermediate between acute & chronic are described as _______.
subacute
Produced by some members of the genus Staphylococcus(italics); forms a fibrin clot around the bacterium.
15
Coagulase
A substance produced by some bacteria that destroys certain phagocytic cells.
15
Leukocidins
pg. 439
Enzymes that cause lysis of RBC's.
15
Hemolysins
Enyzmes that break down fibrin & dissolve clots.
15
Kinases
*can be used more than once*
pg. 434
The fibrinolysins produced by the streptococci.
15
Kinases
*can be used more than once*
pg. 434
May cause hallucinations or gangrene.
15
Ergot
Virulence factor that improves adherence of Neisseria gonorrhoeae(italics).
15
Opa
pg. 433
Tumor necrosis factor.
15
Cachetin
*see glossary
A protein secreted by a bacterium.
15
Exotoxin
The tetanus toxin is a good example.
15
Exotoxin
A lipopolysaccharid component of the cell wall of may gram-negative bacteria.
15
Endotoxin
Released upon lysis of the cell.
15
Endotoxin
Detected by Limulus(italics) amoebocyte lysate assay
15
Endotoxin
The capacity to form toxins.
15
Toxigenicity
Provides immunity to exotoxins.
15
Antitoxin
The presence of a toxin in the bloodstream.
15
Toxemia
A way to measure virulence.
15
LD50
The degree of pathogenicity.
15
Virulence
The ability of a pathogen to cause disease in a host.
15
Pathogenicity
Confers some resistance to phagocytosis.
15
Capsule
Entrance through skin & mucous membranes to gain access to body tissues.
15
Parenteral
Very large multinucleated cells caused by viral infection.
15
Syncytia
An important component of the cell's cytoskeleton that aids in entrance of pathogens into the cell.
15
Actin
pg 435
Produced by virus-infected cells; helps prevent infection of uninfected neighboring cells.
15
Interferon
pg. 444
Portion of the outer wall of gram-negative bacterium that is the endotoxin.
15
Lipid A
Formerly called endogenous pyrogen.
15
Interleukin-1
pg. 440
Membrane-disrupting toxin such as a leukocidin.
15
Streptolysin O
pg. 438-439
Staphylococcal toxic shock syndrome caused by superantigens.
15
Type III toxin (Superantigens)
pg. 438,439
An example is diphtheria toxin, which inhibits protein synthesis & kills the cell.
15
Type I toxin (A-B toxins)
pg. 438
An example is the cell-lysing exotoxin Staphylococcus aureus(italics).
15
Type II toxin (Membrane-Disrupting toxins)
pg. 438
The term LD50 refers to the dose of pathogen that will kill half of the test _____.
15
population
Hyaluronidase is an enzyme secreted by certain bacteria that digests ___________acid.
15
hyaluronic
A disease associated with _____-toxins is septic shock (supply prefix).
15
endo
The limulus(italics) amoebocyte lysate assay is intended to detect _____.
15
Endotoxin
One effect of a viral infection is unregulated cell growth due to loss of _____ inhibition.
15
contact
Contributing to invasiveness by Streptococcus pyogenes(italics) is a cell protein called __ protein.
15
M
pg. 433
With few exceptions, microorganisms cannot penetrate unbroken skin; however some fungi grow on the ________ component of the skin.
15
keratin
The avenue by which a microorganism gains acciess to the body is called its ________.
15
parental route
pg. 430
If the pathogen causes a nonfatal disease, the equivalent to the LD50 test is referred to as ____ (infective dose).
15
ID50
pg. 432
The toxin ergot is contained in resistant mycelia called _________.
15
sclerotia
pg. 445
A microbe is pathogenic only if its characteristics are changed due to a prophage. This is called __________.
15
lysogenic conversion
*this answers #2 on self-test 14*
Explain the relationship between the waxy cell wall of Mycobacterium tuberculosis (italics) and virulence.
15
The waxy lipid cell wall increases the virulence by resisting digestion by phagocytes & can multiply inside phagocytes.
Hi.......... :-)
Hi........... :-)
Produces tears
16
Lacrimal apparatus
The outer layer of skin
16
Epidermis
An oily substance forming a protective film over the skin surface.
16
Sebum
Secreted by cells in mucous membrane; prevents the cavities from drying out.
16
Mucus
Covers larynx during swallowing.
16
Epidermis
The inner portion of the skin, composed of connective tissue.
16
Dermis
The blood fluid.
16
Plasma
p456
Cells & cell fragments of the blood.
16
Formed elements
p456
Immunity based on antibodies.
16
Opsonization
p461/462
Movement by a microorganism toward an attractant chemical.
16
Chemotaxis
p460
An increase in the diameter of blood vessels.
16
Vasodilation
A collection of dead phagocytic cells & fluids.
16
Pus
p465
Vulnerability to a pathogen.
16
Susceptibility
p451
Neutrophils:
16
are granulocytes
p456
Monocytes:
16
Mature into macrophages
p 456
Lymphocytes:
16
No granules in cellular cytoplasm; important to specific immunity.
An increase in the number of while blood cells.
16
Leukocytosis
p458
Projections of the cell membrane of phagocyte.
16
Pseudopods
p462
A larger structure formed when lysosome & phagosome fuse.
16
Phagolysosome
p462
A decrease in the number of white blood cells.
16
Leukopenia
p458
Blood flow decreases as phagocytes stick to the inner lining of blood vessels.
16
Margination
p465
Complement reacts w/mast cells & attached antibodies to release this compound.
16
Histamine
p464
A protein in blood that inhibits microbial growth by reducing the amount of available iron.
16
Transferrin
p473
Controls body temperature.
16
Hypothalamus
Emigration of phagocytes through the vessel wall to damaged tissue.
16
Diapedesis
p465
Protein secreted by bacteria to obtain iron.
16
Siderophore
p473
Polymorphonuclear leukocytes.
16
Neutrophils
p456
Most numverous granulocytes in blood.
16
Neutorphils
*per Ms. Edleman
Stain red or organge w/the acidic dye eosin.
16
Eosinophils
p456
Attach externally to large parasites such as worms & lyse them by discharge of peroxides.
16
Eosinophils
p456
Granulocytes that stain w/basic methylene blue dyes.
16
Basophils
p456
Become macrophages.
16
Monocytes
p456
Kupffer cells in the liver, for example.
16
Macrophages
p460
Innate immunity.
16
Refers to defenses that tend to protect us from any kind of pathogen.
p452
Adaptive immunity.
16
Immunity based on antibody production, for example.
p452
Toll-like receptors.
16
Attach to components of the outer membrane of gram-negative bacteria.
p452
Cytokines.
16
Proteins that regulate the intensity & duration of immune responses.
p452
Dermicidin.
Example of an antimicrobial peptide.
p.473
Some cells of the mucous membrane of the lower respiratory tract contain ________, which are microscopic, hairlike projections.
16
Cilia
The ____________glands produce perspiration.
16
Sweat
*Known as Sudoferous glands
p455
Complement acts in a sequence call a(n)
16
Compliment activation
*picked this because it's a matter of sequence, BUT, CASCADE is another good choice. SEE page 467 for both.
In the membrane attack complex associated w/the action of complement, circular lesions called ________ channels are formed.
16
transmembrane
p467
_________is a group of more than 30 proteins found in blood serum.
16
Complement system
p466
Lymphocytes & monocytes do not have _______ in their cytoplasm.
16
visible granules
p456
???not sure about this one
The coating of micoorganism w/plasma proteins such as antibodies & complement is called _________ & promotes phagocytosis.
16
Opsoniztion
p460
Scar tissue results from ____________-type repair.
Fibrosis......
*tissue-type repair or regeneration-type repair are some other options????
*not sure see 465
The complement pathway that does not involve antibodies is called the ____________ pathway.
16
Alternative
p467
Another name for cellular self-destruction is _______.
16
apoptosis
p458 *bottom of 3rd paragraph.