Suddarth's Textbook of Medical-Surgical Nursing, 13th Edition + Brunner & Suddarth's Textbook of Medical-Surgical Nursing Study Guide, T13th Edition: final nursing 3 Flashcards

Diabetes Mellitus is a metabolic disorder characterized by glucose intolerance or inadequate insulin production of the pancreas. It has two types, namely:

Type 1 or Insulin dependent DM (IDDM) and Type 2 or Non- insulin dependent DM (NIDDM).
The metabolic effects of diabetes mellitus include the decrease in utilization of glucose because insufficiency in insulin supply in the body, an increased fat metabolism, when the body breaks down fat for energy since glucose is not available, and increased protein utilization, referring to an increase in catabolism and protein wasting.

The complications of DM consist of neuropathy, retinopathy, nephropathy, cataracts, glaucoma, pyelonephritis, peripheral vascular lesions, coronary artery disease, stroke and hypertension. With its complications, diabetes mellitus is considered the third leading cause of death by disease and risk factors involve mainly of genetics and obesity.

Nursing Diagnosis: Fluid Volume Deficient (Regulatory Failure)

Possible Etiologies:(Related to)
•Uncontrolled diabetes mellitus
•Osmotic diuresis from hyperglycemia
•Excessive gastric loss (diarrhea and vomiting)
•Restricted or low fluid intake due to nausea or confusion

Defining characteristics: (Evidenced by)
•Statements of fatigue and nervousness
•Increased urinary output
•Concentrated urine
•Weakness
•Thirst
•Sudden weight loss
•Poor skin turgor/ dry skin and mucous membranes
•Hypotension
•Increased pulse rate
•Decreased pulse volume and pressure/ delayed capillary refill
•Change in mental state

Goals/ Objectives:

Short term goal:

Client will maintain hydration at a functional level as evidenced by adequate urine output, stable vital signs, palpable peripheral pulses, good skin turgor and capillary refill, and electrolyte levels within nor

Bipolar disorders are characterized by recurrent mood swings of varying degree from depression to elation with intervening periods of normalcy. Milder mood swings such as cyclothymia may be manifested or viewed as everyday creativity rather than an illness requiring treatment. Hypomania can actually enhance artistic creativity and creative thinking/ problem-solving.

This plan of care focuses on treatment of the manic phase. (Note: Bipolar II disorder is characterized by periods of depression and hypomania, but without manic episodes.)

Psychodynamics
Psychoanalytical theory explains the cyclic behaviors of mania and depression as a response to conditional love from the primary caregiver. The child is maintained in a dependent position, and ego development is disrupted. This gives way to the development of a punitive superego (anger turned inward or depression) or a strong id (uncontrollable impulsive behavior or mania). In the psychoanalytical model, mania is viewed as the mirror image of depression, a “denial of depression.”

Biological
There is increasing evidence to indicate that genetics plays a strong role in the predisposition to bipolar disorder. Research suggests a combination of genes may create this predisposition. Incidence among relatives of affected individuals is higher than in the general population. Biochemically there appear to be increased levels of the biogenic amine norepinephrine in the brain, which may account for the increased activity of the manic individual.

Family Dynamics
Object loss theory suggests that depressive illness occurs if the person is separated from or abandoned by a significant other during the first 6 months of life. The bonding process is interrupted and the child withdraws from people and the environment. Rejection by parents in childhood or spending formative years with a family that sees life as hopeless and has a chronic expectation of failure makes it difficult for the individual to be optimistic. The mother may be distant and unloving, the father a less powerful person, and the child expected to achieve high social and academic success.

•Weight gain
•Impaired memory
•Poor concentration
•Confusion
•Mental slowness
•Hand tremor
•Sedation or lethargy

Avoid antidepressants. The treatment for bipolar depression is different than for regular depression. In fact, antidepressants can actually make bipolar disorder worse or trigger a manic episode. Try mood stabilizers first and never take antidepressants without them, as antidepressants can trigger mania and rapid mood cycling when used on their own.
• Take advantage of natural mood stabilizers. Your lifestyle has an impact on your symptoms. If you make healthy daily choices, you may be able to reduce the amount of medication you need. Mood stabilizers that don’t require a prescription include keeping a strict sleep schedule, exercising regularly, practicing relaxation techniques, and developing a solid support system.
• Add therapy to your treatment plan. Research shows that people who take medication for bipolar disorder tend to recover much faster and control their moods better if they also get therapy. Therapy gives you the tools to cope with life's difficulties, monitor your progress, and deal with the problems bipolar disorder is causing in your personal and professional life.
• Continue taking medication, even after you feel better. The likelihood of having a relapse is very high if you stop taking your bipolar medication. Suddenly stopping medication is especially dangerous. Talk to your doctor before you make any changes, even if you believe you no longer need medication. Your doctor can help you make any adjustments safely.

LITHIUM
Trade Name(s)
•Carbolith [Canada]
•Lithane [Canada]
•Lithmax [Canada]
•Lithobid

Pregnancy Category
Category D

Ther. Class.
mood stabilizers

Indications
Manic episodes of bipolar I disorder (treatment, maintenance, prophylaxis).

Action
•Alters cation transport in nerve and muscle.
•May also influence reuptake of neurotransmitters.

Therapeutic Effect(s):

Prevents/decreases incidence of acute manic episodes.

Pharmacokinetics

Absorption: Completely absorbed after oral administration.

Distribution: Widely distributed into many tissues and fluids; CSF levels are 50% of plasma levels. Crosses the placenta; enters breast milk.

Metabolism and Excretion: Excreted almost entirely unchanged by the kidneys.

Half-life: 20–27 hr.

TIME/ACTION PROFILE (antimanic effects)

Contraindication/Precautions

Contraindicated in:
•Hypersensitivity;
•Severe cardiovascular or renal disease;
•Dehydrated or debilitated patients;
•Brugada syndrome;
•Should be used only where therapy, including blood levels, may be closely monitored;
•Some products contain alcohol or tartrazine and should be avoided in patients with known hypersensitivity or intolerance;
•Lactation: Lactation.

Use Cautiously in:
•Any degree of cardiac, renal, or thyroid disease;
•Diabetes mellitus;
•OB: Fetal cardiac anomalies are associated with lithium use; however, potential maternal benefit may warrant use in some pregnant women;
•Geri: Initial dosage ↓ recommended.

Adverse Reactions/Side Effects

CNS: SEIZURES, fatigue, headache, impaired memory, ataxia, sedation, confusion, dizziness, drowsiness, psychomotor retardation, restlessness, stupor

EENT: aphasia, blurred vision, dysarthria, tinnitus

CV: ECG changes, arrhythmias, edema, hypotension, unmasking of Brugada syndrome

GI: abdominal pain, anorexia, bloating, diarrhea, nausea, dry mouth, metallic taste

GU: polyuria, glycosuria, nephrogenic diabetes insipidus, renal toxicity

Neurologic effects of lithium toxicity include the following:

• Tremors

• Lethargy

• Confusion

• Seizures

• Coma

Gastrointestinal effects of lithium toxicity include the following:

• Nausea

• Vomiting

• Crampy abdominal pain

• Diarrhea

Mild-to-moderate lithium toxicity is characterized by tremor, weakness, and mild confusion. Moderate-to-severe lithium toxicity is characterized by the following:

• Altered mental status

• Muscle fasciculations

• Stupor

• Seizures

• Coma

• Hyperreflexia

• Cardiovascular collapse

The central nervous system (CNS) is the major organ system affected, although the renal, gastrointestinal (GI), endocrine, and cardiovascular (CV) systems also may be involved.

Lithium is available only for oral administration. It is almost completely absorbed from the GI tract. Peak levels occur 2-4 hours postingestion, although absorption can be much slower in massive overdose or with ingestion of sustained-release preparations.

Lithium dosing

Lithium is minimally protein bound (< 10%) and has an apparent volume of distribution of 0.6-1 L/kg. The therapeutic dose is 300-2700 mg/d with desired serum levels of 0.6-1.2 mEq/L.

Lithium clearance is predominantly through the kidneys. Because it is minimally protein bound, lithium is freely filtered at a rate that is dependent upon the glomerular filtration rate (GFR). Consequently, dosing must be adjusted based on renal function. Individuals with chronic renal insufficiency must be closely monitored if placed on lithium therapy.

Most filtered lithium is reabsorbed in the proximal tubule; thus, drugs known to inhibit proximal tubular reabsorption, such as carbonic anhydrase inhibitors and aminophylline, may increase excretion. Diuretics acting distally to the proximal tubule, such as thiazides and spironolactone, do not directly affect the fractional excretion of lithium (although they may affect serum lithium levels indirectly through their effects on volume status). Reabsorption of lithium is increased and toxicity is more likely in patients who are hyponatremic or volume depleted, both of which are possible consequences of diuretic therapy.

Lithium half-life

The plasma elimination half-life of a single dose of lithium is from 12-27 hours (varies with age). The half-life increases to approximately 36 hours in elderly persons (secondary to decreased GFR). Additionally, half-life may be considerably longer with chronic lithium use

Time to steady state - it takes four to five days for a steady state to occur after commencement of lithium (lithium carbonate or lithium citrate) therapy. At this time the first sample should be taken after starting treatment.

Therapeutic range (may vary with respect to different laboratories and therapeutic indication):
## once daily dose - at 12 hours, 0.7 to 1.0 mmol/l; at 24 hours, 0.4 to 0.8 mmol/l
## twice daily dose - at 12 hours, 0.4 to 0.8 mmol/l

Notes:
##NICE state that (2)##serum lithium levels should be checked 1 week after starting and 1 week after every dose change, and until the levels are stable. The aim should be to maintain serum lithium levels between 0.6 and 0.8 mmol per litre in people being prescribed it for the first time
##for people who have relapsed previously while taking lithium or who still have sub-threshold symptoms with functional impairment while receiving lithium, a trial of at least 6 months with serum lithium levels between 0.8 and 1.0 mmol per litre should be considered

Atypical Antipsychotics for Bipolar Disorder

Antipsychotics had a large part in helping many people leave residential mental health care facilities; however, many people found typical antipsychotic side effects intolerable. In the 1970s, second generation antipsychotics, known as atypical antipsychotics, were developed with fewer motor control side effects.

The following atypical antipsychotics are approved for the treatment of bipolar disorder:1
•Aripiprazole (Abilify) – actually considered a third generation antipsychotic; is thought to have fewer metabolic side effects than other antipsychotics. Approved for bipolar mania, mixed state and maintenance treatment.
•Asenapine (Saphris) –newly-approved (mid-2009)2 ; approved to treat bipolar mania and mixed states.
•Olanzapine (Zyprexa) – approved for people age 13 and over with bipolar disorder type 1. FDA-approved for bipolar mania, mixed state and maintenance treatment.
•Quetiapine (Seroquel) – the only antipsychotic approved for the treatment of bipolar depression. Also approved to treat bipolar mania.
•Risperidone (Risperdal) – approved for those age 10 and over with bipolar disorder type 1. FDA-approved for bipolar mania and mixed state treatment.
•Ziprasidone (Geodon) – approved to treat bipolar manic episodes and mixed episodes.

One additional drug, Symbax is approved for the treatment of bipolar depression and is an olanzapine/fluoxetine (Prozac) combination.

Side Effects of Antipsychotic Medications

Antipsychotic medication may be used alone (monotherapy) or with other medications, typically lithium or valproate. While antipsychotics have helped many, this class of medication tends to have a more serious side effect profile and some estimate 50% of people stop taking the drugs due to side effects.3

In first generation typical antipsychotics, the primarily concerning side effects surround involuntary muscle movements. This includes side effects like:4
•Tardive dyskinesia – involuntary repetitive muscle movements
•Dystonia – sustained muscle contractions cause twisting and repetitive movements of abnormal posture
•Akathisia – inner restlessness and an inability to sit still
•Muscle rigidity and tremor
•Seizures

While atypical

Symptoms

Bipolar Symptoms

The primary symptoms of bipolar disorder are dramatic and unpredictable mood swings.

Mania Symptoms

Mania symptoms may include excessive happiness, excitement, irritability, restlessness, increased energy, less need for sleep, racing thoughts, high sex drive, and a tendency to make grand and unattainable plans.

Depression Symptoms

Depression symptoms may include sadness, anxiety, irritability, loss of energy, uncontrollable crying, change in appetite causing weight loss or gain, increased need for sleep, difficulty making decisions, and thoughts of death or suicide.

Types

Bipolar Types

There are several types of bipolar disorder; all involve episodes of depression and mania to a degree. They include bipolar I, bipolar II, cyclothymic disorder, mixed bipolar, and rapid-cycling bipolar disorder.

Bipolar I

A person affected by bipolar I disorder has had at least one manic episode in his or her life. A manic episode is a period of abnormally elevated mood, accompanied by abnormal behavior that disrupts life.

Bipolar II

Bipolar II is similar to bipolar I disorder, with moods cycling between high and low over time. However, in bipolar II disorder, the "up" moods never reach full-on mania.

Rapid Cycling

In rapid cycling, a person with bipolar disorder experiences four or more episodes of mania or depression in one year. About 10% to 20% of people with bipolar disorder have rapid cycling.

Mixed Bipolar

In most forms of bipolar disorder, moods alternate between elevated and depressed over time. But with mixed bipolar disorder, a person experiences both mania and depression simultaneously or in rapid sequence.

Cyclothymia

Cyclothymia (cyclothymic disorder) is a relatively mild mood disorder. People with cyclothymic disorder have milder symptoms than in full-blown bipolar disorder.

Bipolar Spectrum

A peptic ulcer is a defect in the lining of the stomach or the first part of the small intestine, an area called the duodenum. A peptic ulcer in the stomach is called a gastric ulcer. An ulcer in the duodenum is called a duodenal ulcer.

Pathophysiology

A peptic ulcer is an excavation formed in the mucosal wall of the stomach, pylorus, duodenum, or esophagus. It is frequently referred to as a gastric, duodenal, or esophageal ulcer, depending on its location. It is caused by the erosion of a circumscribed area of mucous membrane.

Peptic ulcer has been associated with bacterial infection, such as Helicobacter pylori. The greatest frequency is noted in people between the ages of 40 and 60 years. After menopause, the incidence among women is almost equal to that in men.

Predisposing factors include family history of peptic ulcer, blood type O, chronic use of nonsteroidal antiinflammatory drugs (NSAIDs), alcohol ingestion, excessive smoking, and, possibly, high stress. Esophageal ulcers result from the backward flow of hydrochloric acid from the stomach into the esophagus.

Clinical Manifestations
•Symptoms of an ulcer may last days, weeks, or months and may subside only to reappear without cause. Many patients have asymptomatic ulcers.
•Dull, gnawing pain and a burning sensation in the mid epigastrium or in the back are characteristic.
•Pain is relieved by eating or taking alkali; once the stomach has emptied or the alkali wears off, the pain returns.
•Sharply localized tenderness is elicited by gentle pressure on the epigastrium or slightly right of the midline.
•Other symptoms include pyrosis (heartburn) and a burning sensation in the esophagus and stomach, which moves up to the mouth, occasionally with sour eructation (burping).
•Vomiting is rare in uncomplicated duodenal ulcer; it may or may not be preceded by nausea and usually follows a bout of severe pain and bloating; it is relieved by ejection of the acid gastric contents.
•Constipation or diarrhea may result from diet and medications.
•Bleeding (15% of patients with gastric ulcers) and tarry stools may occur; a small portion of patients who bleed from an acute ulcer have only very mild symptoms or none at all.

Assessment and Diagnostic Methods
•Physical

Medications

The following drugs are sometimes used to treat peptic ulcers caused by either NSAIDs or H. pylori.

Antacids

Many antacids are available without a prescription, and they are the first drugs recommended to relieve heartburn and mild dyspepsia. Antacids are not effective for preventing or healing ulcers, but they can help in the following ways:
They neutralize stomach acid with various combinations of three basic compounds -- magnesium, calcium, or aluminum.
They may protect the stomach by increasing bicarbonate and mucus secretion. (Bicarbonate is an acid-buffering substance.)

It is generally believed that liquid antacids work faster and are more potent than tablets, although some evidence suggests that both forms work equally well.

Basic Salts Used in Antacids. There are three basic salts used in antacids:
Magnesium. Magnesium compounds are available in the form of magnesium carbonate, magnesium trisilicate, and, most commonly, magnesium hydroxide (Milk of Magnesia). The major side effect of these magnesium compounds is diarrhea.
Calcium. Calcium carbonate (Tums, Titralac, and Alka-2) is a potent and rapid-acting antacid, but it can cause constipation. There have been rare cases of hypercalcemia (elevated levels of calcium in the blood) in people taking calcium carbonate for long periods of time. Hypercalcemia can lead to kidney failure.
Aluminum. The most common side effect of antacids containing aluminum compounds (Amphogel, Alternagel) is constipation. Maalox and Mylanta are combinations of aluminum and magnesium, which balance the side effects of diarrhea and constipation. People who take large amounts of antacids containing aluminum may be at risk for calcium loss and osteoporosis. Long-term use also increases the risk of kidney stones. People who have recently experienced GI bleeding should not use aluminum compounds.

Interactions with Other Drugs. Antacids can reduce the absorption of a number of drugs. Conversely, some antacids increase the potency of certain drugs. The interactions can be avoided by taking other drugs 1 hour before or 3 hours after taking the antacid.
Table 1:Drug Interactions with Antacids (such as Maalox, Mylanta)
Antibiotics

H. pylori is usually highly sensitive

Indications and Usage for Piroxicam

Carefully consider the potential benefits and risks of Piroxicam capsule, USP and other treatment options before deciding to use Piroxicam capsule, USP. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

Piroxicam capsule, USP is indicated:
• For relief of the signs and symptoms of osteoarthritis.
• For relief of the signs and symptoms of rheumatoid arthritis.

Contraindications

Piroxicam capsule, USP is contraindicated in patients with known hypersensitivity to Piroxicam.

Piroxicam capsule, USP should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients (see WARNINGS: Anaphylactoid Reactions and PRECAUTIONS: Preexisting Asthma).

Piroxicam capsule, USP is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

CARDIOVASCULAR EFFECTS

Cardiovascular Thrombotic Events

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke, which can be fatal. All NSAIDs, both COX-2 selective and nonselective, may have a similar risk. Patients with known CV disease or risk factors for CV disease may be at greater risk. To minimize the potential risk for an adverse CV event in patients treated with an NSAID, the lowest effective dose should be used for the shortest duration possible. Physicians and patients should remain alert for the development of such events, even in the absence of previous CV symptoms. Patients should be informed about the signs and/or symptoms of serious CV events and the steps to take if they occur.

There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The conc

Some severe symptoms include:

•Dark-stained vomitus
•Vomiting dark and clotted blood
•Black tarry stools
•Pale skin due to anemia
•Weight loss
•Abdominal pain
•Loss of appetite

Common Muscle Relaxant Medications

Muscle relaxants usually used to treat back pain and other types of pain include:
•Baclofen
Muscle tightness and muscle spasms, including those related to spine injuries, are eased with baclofen. The medication may be helpful in treating multiple sclerosis and stabbing nerve pain. It is available as a tablet and can be taken by children as young as 12 years old. Some common side effects could include nausea and vomiting, confusion, drowsiness, headache, or muscle weakness. Baclofen is rated C in the FDA’s A through X pregnancy safety ranking for medications, with A being the safest.

•Chlorzoxazone (Lorzone, Parafon Forte DSC)
Chlorzoxazone is used for the relief of discomfort from acute, painful, musculoskeletal conditions. It should not be used in patients with hypersensitivity to chlorzoxazone and rare liver toxicity has been reported. The doctor should be contacted in case of loss of appetite; nausea, vomiting, or tiredness; stomach pain; dark urine; pale stools; or yellowing of the skin or eyes. Chlorzoxazone is available as a tablet. It has not been rated by the FDA for safety during pregnancy.

•Carisoprodol (Soma)
Carisoprodol relaxes muscles and eases pain and stiffness caused by acute bone and muscle problems, as may be caused by an injury. It can be habit-forming, particularly if used in conjunction with alcohol or other drugs that have a sedative effect. Patients with a history of acute intermittent porphyria or hypersensitivity to carbamate medications such as methocarbamol should avoid carisoprodol. It is taken by mouth in tablet form and is also available in combination with aspirin or aspirin and codeine. It is rated C in the FDA’s pregnancy safety ranking for medications.

•Cyclobenzaprine (e.g. Amrix, Cyclobenzaprine Comfort Pac Fexmid, FlexePax, Flexeril, FusePaq Tabradol, Therabenzaprine-60)
Cyclobenzaprine eases stiffness and pain from muscle cramps, also called spasms. It is not advised for those with an overactive thyroid, heart rhythm problems, heart failure, or those who have had a heart attack recently. It can be used on a longer-term basis and has a chemical structure related to some ant

Since celecoxib is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose

Overdose symptoms may include nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, shallow breathing, fainting, or coma.

What should I avoid while taking celecoxib (Celebrex)?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking celecoxib together with other NSAIDs such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn, Naprelan, Treximet), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), or piroxicam (Feldene).

Ask a doctor or pharmacist before using any other cold, allergy, or pain medicine. Medicines similar to celecoxib are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain type of drug Check the label to see if a medicine contains an NSAID (non-steroidal anti-inflammatory drug) such as aspirin, ibuprofen, ketoprofen, or naproxen.

Avoid exposure to sunlight or tanning beds. Celecoxib can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What other drugs will affect celecoxib (Celebrex)?

Ask your doctor before using an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft). Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all other medicines you use, especially:

CHOLECYSTITIS WITH CHOLELITHIASIS

2.Cholecystitis is an acute or chronic inflammation of the gallbladder, usually associated with gallstone(s) impacted in the cystic duct, causing distension of the gallbladder.

3. Stones (calculi) are made up of cholesterol, calcium bilirubinate, or a mixture caused by changes in the bile composition. Gallstones can develop in the common bile duct, the cystic duct, hepatic duct, small bile duct, and pancreatic duct.

4.Crystals can also form in the submucosa of the gallbladder causing widespread inflammation. Acute cholecystitis with cholelithiasis is usually treated by surgery, although several other treatment methods (fragmentation and dissolution of stones) are now being used.

5.CARE SETTING Severe acute attacks may require brief hospitalization on a medical unit. This plan of care deals with the acutely ill, hospitalized patient.

6.RELATED CONCERNS Cholecystectomy Fluid and electrolyte imbalances,Psychosocial aspects of care Total nutritional support: parenteral/enteral feeding Patient Assessment Database

7.ACTIVITY/REST May report: Fatigue May exhibit: Restlessness

8 .CIRCULATION May exhibit: Tachycardia, diaphoresis, lightheadedness

9.ELIMINATION May report: Change in color of urine and stools May exhibit: Abdominal distension Palpable mass in right upper quadrant (RUQ) Dark, concentrated urine Clay-colored stool, steatorrhea

10.FOOD/FLUID May report: Anorexia, nausea/vomiting Intolerance of fatty and “gas-forming” foods; recurrent regurgitation, heartburn, indigestion, flatulence, bloating (dyspepsia) Belching (eructation) May exhibit: Obesity; recent weight loss Normal to hypoactive bowel sounds

11. PAIN/DISCOMFORT May report: Severe epigastric and right upper abdominal pain, may radiate to mid-back, right shoulder/scapula, or t

Right upper quadrant:organs
Liver
Gall bladder with biliary tree
Duodenum
Head of pancreas
Right kidney and adrenal gland
Hepatic flexure of colon

-- Lie the patient supine (as you would during any other abdominal assessment);
-- Instruct the patient to breath out;
-- Place your palpating hand just below the costal margin, approximately mid-clavicularly (this is just above the gallbladder);
-Then instruct the patient to slowly breath in;

A positive Murphy’s sign is identified when the patient stops breathing in due to pain -- this is caused by the move of the diaphragm pushing the inflamed gallbladder into the palpating hand.

A negative Murphy’s sign is identified when the patient comfortable breaths all the way in without any pain -- in this case, the diaphragm pushes the non-inflamed gallbladder into the palpating hand with nil changes in the patient’s level of comfort.

A positive Murphy’s sign often indicates Cholycystitis, where as a negative Murphy’s sign may suggest pyelonephritis, and ascending cholangitis.

The abdominal wall is compressed slowly and then rapidly released. A positive sign is indicated by presence of pain upon removal of pressure on the abdominal wall. It is very similar to rebound tenderness and might be regarded by some authors as the same thing, or at least a particular application of it.

It represents aggravation of the parietal layer of peritoneum by stretching or moving.

Positive Blumberg sign or rebound tenderness is indicative of peritonitis which can occur in diseases like appendicitis, and may occur in ulcerative colitis with rebound tenderness in the right lower quadrant. This method is specially useful in diagnosing appendicitis requiring urgent management.

However, in recent years the value of rebound tenderness has been questioned, since it may not add any diagnostic value beyond the observation that the patient has severe tenderness

This anomaly occurs because the pain nerves deep in the intestines do not localize well to an exact spot on the abdominal wall, unlike pain nerves in muscles. Pain from a stomach ulcer or gallstone can be interpreted by the brain as pain from the stomach, liver, gall bladder, duodenum, or first part of the small intestine. It will "refer" pain often to the mid upper abdomen.

Because the appendix is a piece of intestine, it follows a similar referral pattern. An appendix with some early inflammation may give a non-specific irritation somewhere near the umbilicus (belly button). Should the inflammation become severe, it may actually irritate the inner lining of the abdominal cavity called the peritoneum. This thin layer lies under or behind the abdominal wall muscles. Now the pain is "localized". If pressure is applied to the muscles of the right lower abdomen (or iliac fossa) near a very irritated appendix, then the muscle fibers in that area will be stretched and will hurt.

• Liver function tests (LFTs), which are blood tests that can show evidence of gallbladder disease.
•A check of the blood's amylase or lipase levels to look for inflammation of the pancreas. Amylase and lipase are enzymes (digestive chemicals) produced in the pancreas.
•A complete blood count (CBC), which looks at levels of different types of blood cells such as white blood cells. A high white blood cell count may indicate infection.
•The use of ultrasound testing which uses sound waves to image and make a picture of the intra-abdominal organs including the gallbladder.
•An abdominal X-ray, which may show evidence of gallbladder disease, such as gallstones.
•A computed tomography (CT) scan constructs a detailed X-ray images of the abdominal organs.
•A HIDA scan. In this test, a radioactive material called hydroxy iminodiacetic acid (HIDA) is injected into the patient. The radioactive material is taken up by the gallbladder to measure gallbladder emptying function. This test also is referred to as cholescintigraphy.
•Magnetic resonance cholangiopancreatography (MRCP), which uses magnetic resonance imaging (MRI) to produce detailed pictures.
•Endoscopic retrograde cholangiopancreatography (ERCP), a procedure in which a tube is placed down the patient's throat, into the stomach, then into the small intestine. Dye is injected and the ducts of the gallbladder, liver, and pancreas can be seen on X-ray.

Symptoms of bile duct obstruction include the following:
•Upper right side abdominal pain
•Nausea or vomiting
•Sweating/chills
•Fever
•Dark urine
•Loss of appetite (inappetance)
•Weight loss
•Pale stools
•Greasy stool
•Yellow eyes
•Yellowish skin or jaundice

The following blood test results could be due to a possible blockage:
Increased bilirubin level
Increased alkaline phosphatase level
Increased liver enzymes

The following tests may be used to investigate a possible blocked bile duct:
Abdominal ultrasound
Abdominal CT scan
ERCP (endoscopic retrograde cholangiopancreatography)
Percutaneous transhepatic cholangiogram (PTCA)
Magnetic resonance cholangiopancreatography (MRCP)

A blocked bile duct may also alter the results of the following tests:
Amylase blood test
Gallbladder radionuclide scan
Lipase blood test
Prothrombin time (PT)
Urine bilirubin

The goal of treatment is to reli

1.Lower respiratory tract infections, including pneumonia and bronchitis as an exacerbation of COPD (chronic obstructive pulmonary disease) caused by Streptococcus pneumoniae and Haemophilus influenzae.
2. Intra-abdominal infections, including acute gangrenous or perforated appendicitis and appendicitis with peritonitis, caused by Group D streptococcus including Enterococcus faecalis*; Streptococcus viridans group*; Escherichia coli; Klebsiella pneumoniae*; Pseudomonas aeruginosa*; Bacteroides species including B. fragilis, B. distasonis*, B. intermedius* and B. thetaiotaomicron*; Fusobacterium species; and Peptostreptococcus* species.
3.Skin and skin structure infections, including abscesses, cellulitis, infected skin ulcers and wound infections caused by Staphylococcus aureus including penicillinase-producing strains; Streptococcus pyogenes*; Group D streptococcus including Enterococcus faecalis; Acinetobacter species* including A. calcoaceticus*; Citrobacter species*; Escherichia coli; Enterobacter cloacae; Klebsiella pneumoniae*; Pseudomonas aeruginosa*; and Bacteroides species* including B. fragilis*.
4. Gynecologic infections, including postpartum endomyometritis, caused by Group D streptococcus including Enterococcus faecalis*; Escherichia coli; Klebsiella pneumoniae*; Bacteroides intermedius*; and Peptostreptococcus species*.

As with other beta-lactam antibiotics, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with PRIMAXIN I.M. During therapy of Pseudomonas aeruginosa infections, periodic susceptibility testing should be done when clinically appropriate.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of PRIMAXIN I.M. and other antibacterial drugs, PRIMAXIN I.M. should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Hydrocolloid dressings do not need to be changed as often as other types of wound dressings. New dressing only needs to be applied every 3-7 days, which leaves the wound undisturbed longer. This also makes the hydrocolloid dressings more cost effective, not only in terms of materials, but by reducing the cost of service provided by a health care professional. Hydrocolloid dressings also reduce pain and promote faster healing. When compared to paraffin gauze to dress skin graft donor sites, hydrocolloid dressings may result in less pain and faster healing. A study of patients with lacerations and shallow surgical incisions found patients who used hydrocolloid dressings required less analgesia to perform daily activities.

Impermeable to Bacteria

Hydrocolloid dressings significantly lower the risk of infection because they are impermeable to bacteria. Most are water proof, allowing patients to proceed with normal bathing. An 8-week study was performed on bacteria found in venous ulcers to which occlusive hydrocolloid dressing was applied. The study found that the level of bacteria was generally stable. Most species that were observed remained, apart from pseudomonas which appeared to be repressed by the hydrocolloid dressing. Bacteria were found present in 12 of the 20 ulcers examined, but there was no evidence that any species deterred healing.

Adheres Only to Intact Skin

Hydrocolloid dressings do not adhere to the wound, only to the skin surrounding it. This helps keep newly healed skin intact. Moisture is generated beneath the dressing to promote healing and prevent break down of tissue. In addition, hydrocolloid dressings do not traumatize the skin upon being removed. They are also available in contoured shapes to form with specific body parts.

Simple to Apply

Applying hydrocolloid dressing to a wound is simple. Before applying the dressing, wash your hands and put on clean gloves. Clean the wound and use clean gauze to dab the area around the wound until it is as dry as it can get. Remove the gloves once again, wash your hands and put on a clean pair of gloves. Administer a film of moisture barrier around the wound and apply filler if the wound is deep. Allow the hydrocolloid dressing to warm between your hands for a few minutes before applying it. Once you have removed the paper from the back, place the dr

Electrolytes

See the list below:

•Ammonia: 15-50 µmol/L

•Ceruloplasmin: 15-60 mg/dL

•Chloride: 95-105 mmol/L

•Copper: 70-150 µg/dL

•Creatinine: 0.8-1.3 mg/dL

•Blood urea nitrogen: 8-21 mg/dL

•Ferritin: 12-300 ng/mL (men), 12-150 ng/mL (women)

•Glucose: 65-110 mg/dL

•Inorganic phosphorous: 1-1.5 mmol/L

•Ionized calcium: 1.03-1.23 mmol/L

•Magnesium: 1.5-2 mEq/L

•Phosphate: 0.8-1.5 mmol/L

•Potassium: 3.5-5 mmol/L

•Pyruvate: 300-900 µg/dL

•Sodium: 135-145 mmol/L

•Total calcium: 2-2.6 mmol/L

•Total iron-binding capacity: 45-85 µmol/L

•Total serum iron: 65-180 µg/dL (men), 30-170 µg/dL (women)

•Transferrin: 200-350 mg/dL

•Urea: 1.2-3 mmol/L

•Uric acid: 0.18-0.48 mmol/L

•Zinc: 70-100 µmol/L

Lipids

See the list below:

•Triglycerides: 50-150 mg/dL

•Total cholesterol: 3-5.5 mmol/L

•High-density lipoprotein (HDL): 40-80 mg/dL

•Low-density lipoprotein (LDL): 85-125 mg/dL

Acid base

See the list below:

•pH: 7.35-7.45

•Base excess: (-3)-(+3)

•H+: 36-44 nmol/L

•Partial pressure of oxygen (pO2): 75-100 mm Hg

•Oxygen saturation: 96%-100%

•Partial pressure of carbon dioxide (pCO2): 35-45 mm Hg

•Bicarbonate (HCO3): 18-22 mmol/L

Gastrointestinal function

See the list below:

•Albumin: 35-50 g/L

•Alkaline phosphatase: 50-100 U/L

•Alanine aminotransferase (ALT): 5-30 U/L

•Amylase: 30-125 U/L

•Aspartate aminotransferase (AST): 5-30 U/L

•Direct bilirubin: 0-6 µmol/L

•Gamma glutamyl transferase: 6-50 U/L

•Lipase: 10-150 U/L

•Total bilirubin: 2-20 µmol/L

•Total protein: 60-80 g/L

Laparoscopic Cholecystectomy Discharge Instructions

You will most likely tire easily for about 1-2 weeks. This is normal. Plan to take rest periods throughout each day as you feel you need them. Occasionally patients may have trouble with bowel movements for up to a month after surgery; constipation may be relieved by increasing fluid intake or taking a stool softener or mild laxative, diarrhea should subside within a few weeks. Generally patients find they are back to their usual routine within 1-2 weeks after surgery and fully recovered within a month.

Medication

Acetaminophen (Tylenol) regular or extra strength 1-2 tablets every 4-6 hours as needed for mild pain.

Vicodin (Acetaminophen with Codeine)(prescription only) as directed for moderate pain.

Over the counter stool softener or laxative daily as needed for constipation.

Diet

Try to drink 8-10 glasses per day Juice or water).

For the first few days, you may eat whatever was easy to digest before surgery and then progress to a normal diet as tolerated.

Bathing Showering

You may shower/bathe 24 hours after surgery.

You may use a mild soap to gently cleanse your incision and carefully pat dry.

Coronary heart disease is mainly caused by the process of atherosclerosis which is a degenerative disorder. Coronary heart disease is the imbalance between myocardial oxygen supply needs.

Coronary heart disease occurs due to:
•Narrowing of the coronary arteries
•Decreased blood flow / cardiac output
•The increase in myocardial oxygen demand
•Coronary artery spasm

Main causes of atherosclerosis. Although influenced by many factors, due to degenerative disorder, it often causes sudden death and attacked very productive age.

Input to the oxygen demand imbalance, namely:
1.Hypoxemia (ischemia), caused by vascular disorders (coronary arteries). On ischemic vascular abnormalities that are reduced tissue perfusion to metabolic elimination caused by (eg lactic acid) decreased as well, so it will be faster symptoms appear.
2.Hypoxia (anoxia), caused by lack of oxygen in the blood. Actual input of oxygen to the myocardium depends on the oxygen in the blood and the coronary arteries. Oxygen in the blood depends on the oxygen can be taken up by the blood. So influenced by Hb, lungs and oxygen in the breathing air.

Palpitations are manifestations of coronary heart disease although not specific. Manifestations of coronary heart disease varies depending on the degree of coronary artery blood flow. When coronary flow is still sufficient for the tissue will not cause any complaints / clinical manifestations. Factors that affect large and coronary flow properties such as the state of anatomical and mechanical factors, autoregulation system and peripheral resistance.

The trigger factor that adds to ischemia such as, physical activity, stress, etc.. Angina pectoris is the main symptom specific and typical for coronary heart disease. Shortness of breath began to feel short of breath while doing activities that are sufficiently severe, increasing shortness of breath. At a more advanced state of heart failure can occur.

Atherosclerosis is the most common cause of CAD and is linked to many risk factors—primarily elevated serum cholesterol levels, elevated blood pressure, and cigarette smoking. Blood levels of cholesterol and low-density lipoproteins (LDLs) have been associated with increased risk of CAD. Hypertension places chronic stress on the blood vessels and may initiate plaque deposition. Because smoking increases myocardial oxygen requirements, blood pressure, and heart rate, cigarette smokers are twice as likely to have an MI and four times as likely to have sudden cardiac death. Other risk factors include heredity, obesity, lack of physical activity, stress, and diabetes mellitus.

Nursing care plan assessment and physical examination

Patients with CAD describe symptoms of myocardial ischemia. A careful description of the pain, including location, severity, and precipitating factors, is essential. The most common symptom is angina, but some individuals remain asymptomatic. Cardiac pain is usually described as a diffuse aching pain or pressure that is relieved by rest or administration of nitroglycerin. The pain is usually substernal but may radiate to either arm, the neck, or between the shoulder blades. Often, the pain is precipitated by extra physical or emotional demands. Atypical pain may originate in the elbow, jaw, or shoulder. The patient may have no pain sensation but may complain of being short of breath or having nausea, vomiting, lightheadedness, or sweating.

Physical examination may reveal nothing abnormal. Labored breathing, pallor, and profuse sweating suggest that chest pain may be caused by MI. There may be evidence of flat or slightly raised yellowish tumors, most frequently found on the upper and lower lids (xanthelasma), or flat, slightly elevated, soft, rounded plaques or nodules, usually on the eyelids (xanthoma). Auscultate the heart sounds carefully to identify accompanying cardiac problems such as valvular dysfunction or heart failure.

Because the stress in one’s life has long been associated with the development of CAD, problem solving to reduce stress is an important nursing function. Occupational stress or the obligations from multiple roles may vary for female and male patients. Individuals whose work involves heavy lifting may require vocational rehabilitation counseling in order to return to work. Conti

HEAD

HEART

MUSCLE

KNEES

sodium imbalance quite often there will be changes in mental status - confusion, delirium, etc. Often seen with traumatic brain injury where diabetes insipidus (pathological voiding of large amounts of dilute urine) and its opposite SIADH (syndrome of inappropriate antidiuretic hormone - minimal urine output but very concentrated) may occur. Sodium imbalances are also seen with dehydration in some patients (elderly, burn victims, many others) and the blood levels will go up. Very rarely, sodium levels in the blood will go down because of consuming large quantities of fluids.

Potassium homeostasis is maintained by the balance of potassium excretion and potassium cellular shifts.
•Potassium excretion is tightly regulated by the kidneys.
•Potassium cellular shifts are principally mediated by hormones.

formation and structure of bones and teeth, cell structure and function, cell membrane permeability and impulse transmission, the contraction of all muscle types and is necessary in the blood clotting process

important in the digestive acids; closely linked to sodium

LIKE CHLORINE IN THE POOL , TEMPS OUTSIDE 98-106

affects nerve and muscle action by affecting calcium usage, activates enzymes involved in carbohydrate and protein metabolism, helps in the transport of sodium and potassium across cell membranes, and influences the levels of sodium, potassium, calcium and some body hormones (parathyroid hormone)

formation and structure of bones and teeth, this electrolyte is needed in the following activities: utilization of B vitamins, acid base homeostasis, bone formation, nerve and muscle activity, cell division, the transmission of hereditary traits, metabolism of carbohydrates, proteins and fats

7.35-7.45

Nonrenal losses (urine K+ < 20 mmol/L) •Diarrhea, laxative abuse
•Vomiting

Renal losses (urine K+ >?20 mmol/L) •Loop diuretics (furosemide, bumetanide, torsemide): block chloride-coupled sodium reabsorption in the loop of Henle
•Thiazide diuretics (hydrochlorothiazide): block distal tubule chloride-coupled sodium reabsorption
•Osmotic diuresis (uncontrolled diabetes)

Hypokalemia with hypertension •Mineralocorticoid excess
•Primary hyperaldosteronism
•Glucocorticoid-remediable aldosteronism: renovascular hypertension, renin-secreting tumor, Liddle syndrome
•Apparent mineralocorticoid excess: 11β-hydroxysteroid dehydrogenase deficiency (genetic, drug induced [chewing tobacco, licorice], congenital adrenal hyperplasia)

Hypokalemia with normal blood pressure •Bartter's syndrome
•Gitelman's syndrome
•Magnesium depletion (cis-platinum, alcoholism)
•Renal tubular acidosis (types 1 and 2)

Box 3 Causes of Hyperkalemia

Spurious •Thrombocytosis (>1,000,000/mm3)
•Leukocytosis (>50,000/mm3)
•Hemolysis
•Repeated fist clenching with tourniquet in place

Impaired potassium excretion •Renal insufficiency or failure
•Mineralocorticoid deficiency
•Addison’s disease
•Hyporenin hypoaldosteronism (type 4 renal tubular acidosis)
•Hereditary enzyme deficiencies

Pseudohypoaldosteronism
Drugs •Block sodium channel in distal nephron-trimethoprim, pentamidine, potassium-sparing diuretics (amiloride, triamterene)
•Block aldosterone production: ACE inhibitors, angiotensin receptor blockers, NSAIDs, and COX-2 inhibitors, heparin, tacrolimus
•Block aldosterone receptors: spironolactone, eplerenone
•Block Na+, K+-ATPase activity in the distal nephron: cyclosporine

Impaired transcellular shift-insulin deficiency
Hypertonicity (uncontrolled diabetes): familial hyperkalemic periodic paralysis •Drugs-beta blockers, digoxin (at toxic levels), succinylcholine, arginine, lysine

Excessive potassium load
Massive tissue breakdown (rhabdomyolysis, burns, trauma)

ACE, angiotensin-converting enzyme; COX-2, Cyclooxygenase-2; NSAID, nonsteroidal anti-inflammatory drug.

Reduction in Risk of Myocardial Infarction, Stroke, and Death from Cardiovascular Causes

Altace (ramipril capsules) is indicated in patients 55 years or older at high risk of developing a major cardiovascular event because of a history of coronary artery disease, stroke, peripheral vascular disease, or diabetes that is accompanied by at least one other cardiovascular risk factor (hypertension, elevated total cholesterol levels, low HDL levels, cigarette smoking, or documented microalbuminuria), to reduce the risk of myocardial infarction, stroke, or death from cardiovascular causes. Altace (ramipril capsules) can be used in addition to other needed treatment (such as antihypertensive, antiplatelet or lipid-lowering therapy).

Hypertension

ALTACE (ramipril capsules) is indicated for the treatment of hypertension. It may be used alone or in combination with thiazide diuretics. In using ALTACE (ramipril capsules) , consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen-vascular disease. Available data are insufficient to show that ALTACE does not have a similar risk. (See WARNINGS .)

In considering use of ALTACE (ramipril capsules) , it should be noted that in controlled trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition, ACE inhibitors (for which adequate data are available) cause a higher rate of angioedema in black than in non-black patients. (See WARNINGS , Angioedema.)

Heart Failure Post Myocardial Infarction

Ramipril is indicated in stable patients who have demonstrated clinical signs of congestive heart failure within the first few days after sustaining acute myocardial infarction. Administration of ramipril to such patients has been shown to decrease the risk of death (principally cardiovascular death) and to decrease the risks of failure-related hospitalization and progression to severe/resistant heart failure. (See CLINICAL PHARMACOLOGY , Heart Failure Post Myocardial Infarction for details and limitations of the survival trial.)

Adverse Event Ramipril Placebo
(n=1004) (n=982)
Hypotension 11 5
Cough Increased 8 4
Dizziness 4 3
Angina Pectoris 3 2
Nausea 2 1
Postural Hypotension 2 1
Syncope 2 1
Vomiting 2 0.5
Vertigo 2 0.7
Abnormal Kidney Function 1 0.5
Diarrhea 1 0.4

The Connection Between Grapefruit and Statins

Highlights
1 Grapefruit can affect the rate at which drugs are processed by the liver.
2 These include many drugs used to treat blood vessel and heart conditions, such as statins.
3 The interaction is particularly strong with two types of statins: Zocor and Lipitor.

refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. While there are many causes of peripheral vascular disease, doctors commonly use the term peripheral vascular disease to refer to peripheral artery disease (peripheral arterial disease, PAD), a condition that develops when the arteries that supply blood to the internal organs, arms, and legs become completely or partially blocked as a result of atherosclerosis

is a gradual process whereby hard cholesterol substances (plaques) are deposited in the walls of the arteries. Cholesterol plaques cause hardening of the artery walls and narrowing of the inner channel (lumen) of the artery. The atherosclerosis process begins early in life (as early as teens in some people).

most common symptom of ________________is intermittent claudication, manifested by pain (usually in the calf) that occurs while walking and dissipates at rest.

Heart attack: permanent damage to the heart muscle caused by a lack of blood supply to the heart for an extended time

Stroke: interruption of the blood flow to the brain

Transient ischemic attack (TIA): a temporary interruption in the blood supply to the brain)

Renal artery disease or stenosis: a narrowing or blockage of the artery that supplies blood to the kidney

Amputation: the removal of part or all of the foot or leg (rarely the arm), especially in people who also have diabetes

Pulse and blood pressure checks in different areas of your body. Your doctor may also look at the color of your foot when it is elevated and after you exercise.
• Ankle-brachial index (ABI) test checks blood flow by comparing blood pressure in the ankles and the arms.
• Doppler ultrasound. It may be used to measure blood flow in the arteries.
• Magnetic resonance angiogram (MRA) or computerized tomography (CT) angiography. These tests can also help diagnose PAD. These tests might be done before a procedure or surgery

There are many risk factors for high blood pressure. Some factors you can’t change. Others are modifiable based on your lifestyle. Risk factors you cannot change include:
•age: Older adults are at greater risk for high blood pressure.
•gender: Women over 65 are more likely to have higher blood pressure, and men under age 45 are more likely to have high blood pressure than women.
•race: African-Americans are more likely to have high blood pressure.
•family history: If your direct family members (parent or sibling) have high blood pressure, you are more at risk.

Factors that are modifiable include:
• being overweight
•not exercising enough
•eating an unhealthy diet
•consuming excess salt
•drinking alcohol
•smoking
•sleep apnea
•stress

Grade I is a clean wound less than 1 cm long. Grade II is a larger wound without extensive soft tissue damage or avulsions. Grade III is highly contaminated and has extensive soft tissue damage. It may be accompanied by traumatic amputation and is the most severe

Fat emboli occur in almost 90% of all people with severe injuries to bones, although only 10% of these are symptomatic. The risk of fat embolism syndrome is thought to be reduced by early immobilization of fractures and especially by early operative correction. There is also some evidence that steroid prophylaxis of high-risk patients reduces the incidence. The mortality rate of fat-embolism syndrome is approximately 10–20%

Fat emboli can be either traumatic (resulting from fracture of long bones, accidents, or trauma to soft tissue) or non-traumatic (resulting from burns or fatty liver).

Pathogenesis

The pathogenesis occurs due to both mechanical obstruction and biochemical injury. It is aggravated by local platelet and erythrocyte aggregation. The release of fatty acids from the fat globules also causes local toxic injury to endothelium. The vascular damage is aggravated by platelet activation and recruitment of granulocytes.

Several mechanisms have been proposed to explain the pathogenesis of fat embolism. They may be acting together or singly

1.Mechanical. Mobilisation of fluid fat following trauma to bone and soft tissue
2.Emulsion instability. Explains the pathogenesis of fat embolism in non-traumatic cases. Fat embolus formed by aggregation of plasma lipids (chylomicrons and fatty acids) due to disturbances in emulsification of fat. Symptoms include fatty liver (hepatic steatosis).
3.Intravascular coagulation. May result from disseminated intravascular coagulation (DIC).
4.Toxic injury. Blood vessels injured by high plasma levels of free fatty acid, results in increased vascular permeability and consequently pulmonary edema.

Complications

Complications from a fat embolism tend to be serious:
1.Pulmonary fat embolism. Widespread obstruction causes sudden death.
2.Systemic fat embolism. These may get lodged in capillaries of organs like brain, kidney, skin etc., causing minute hemorrhage and microinfarcts.[5]

Embolized fat travels through the venous system to the lungs and can occlude pulmonary capillaries. Fat emboli may cause cor pulmonale if adequate compensatory pulmonary vasodilation does not occur.

Circulating free fatty acids are directly toxic to pneumocytes and capillary endothelium in the lung, causing interstitial hemorrhage, edema and chemical pneumonitis.

Acute compartment syndrome is the most common type of compartment syndrome. About three-quarters of the time, acute compartment syndrome is caused by a broken leg or arm. Acute compartment syndrome develops rapidly over hours or days.

Compartment syndrome can develop from the fracture itself, due to pressure from bleeding and edema. Or compartment syndrome may occur later, as a result of treatment for the fracture (such as surgery or casting).

Acute compartment syndrome can also occur after injuries without bone fractures, including:
•Crush injuries
•Burns
•Overly tight bandaging
•Prolonged compression of a limb during a period of unconsciousness
•Surgery to blood vessels of an arm or leg
•A blood clot in a blood vessel in an arm or leg
• Extremely vigorous exercise, especially eccentric movements (extension under pressure

Repeat the same sequence:
1.Place crutches forward.
2.Step with weaker leg.
3.Step with stronger leg.

Lortab contains a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.

Lortab is used to relieve moderate to severe pain.

Lortab may also be used for purposes not listed in this medication guide.