What are the different types of dementia
Alzheimer's disease, vascular dementia and lewy body dementia
Pathophysiology of Alzheimer's dementia
involves neuritic plaques (clusters of beta-amyloid protein) and tangles (accumulation of tau protein) in brain tissue, which interrupt neuron signaling, and/or alteration of neurotransmitter
What is flortaucipr F18 (Tauvid)
a radioactive imaging drug to estimate the tau protein tangles in adult patients being evaluated for alzheimer's disease
Assessment used to identify or screen for dementia
mini-mental state exam (MMSE)
(max score is 30, score <24 indicates a memory disorder)
Supplements with possible benefit for alzheimer's dementia
vitamin E (2000 IU daily) and ginkgo
(both of these increase bleeding risk)
Primary treatment for alzheimer's disease
acetylcholinesterase inhibitors
What drugs are acetylcholinesterase inhibitors
donepezil, rivastigmine, galantamine
MOA of acetylcholinesterase inhibitors
inhibit centrally-active acetylcholinesterase, the enzyme responsible for hydrolysis (breakdown) of acetylcholine, this cause an increase in acetylcholine
Brand name of donepezil
Aricept
Brand name of rivastigmine
Exelon
Brand name of galantamine
Razadyne ER
Brand name of donepezil + memantine
Namzaric
MOA of memantine
blocks NMDA receptors, which inhibits glutamate from binding and decreasing abnormal neuron activation
Brand name of memantine
Namenda
When taking donepezil, what can help decrease nausea
taking at night
Which acetylcholinesterase inhibitors comes in a patch
rivastigmine and donepezil
If stable on donepezil 10 mg, can switch to
Namzaric (memantine 7 mg/ donepezil 10 mg)
How to apply rivastigmine patch
apply new patch at the same time each day to the upper or lower back or on the upper arm or chest (do not use the same site within 14 days)
Brand name for donepezil patch
Adlarity
Where should Adlarity be stored
refrigerator
How to apply Adlarity
apply a new patch at the same time each week to the upper or lower back, upper butt or upper outer thigh (remove after 7 days)