division of the anterior (ventral) cavity that houses the abdominal and pelvic viscera
abdominopelvic cavity
assembly of more complex molecules from simpler molecules
anabolism
standard reference position used for describing locations and directions on the human body
anatomical position
science that studies the form and composition of the body’s structures
anatomy
describes the front or direction toward the front of the body; also referred to as ventral
anterior
larger body cavity located anterior to the posterior (dorsal) body cavity; includes the serous membrane-lined pleural cavities for the lungs, pericardial cavity for the heart, and peritoneal cavity for the abdominal and pelvic organs; also referred to as ventral cavity
anterior cavity
breaking down of more complex molecules into simpler molecules
catabolism
describes a position below or lower than another part of the body proper; near or toward the tail (in humans, the coccyx, or lowest part of the spinal column); also referred to as inferior
caudal
smallest independently functioning unit of all organisms; in animals, a cell contains cytoplasm, composed of fluid and organelles
cell
medical imaging technique in which a computer-enhanced cross-sectional X-ray image is obtained
computed tomography (CT)
compares values to their normal range; deviations cause the activation of an effector
control center
describes a position above or higher than another part of the body proper; also referred to as superior
cranial
division of the posterior (dorsal) cavity that houses the braina
cranial cavity
describes a position farther from the surface of the body
deep
changes an organism goes through during its life
development
process by which unspecialized cells become specialized in structure and function
differentiation
describes a position farther from the point of attachment or the trunk of the body
distal
describes the back or direction toward the back of the body; also referred to as posterior
dorsal
posterior body cavity that houses the brain and spinal cord; also referred to the posterior body cavity
dorsal cavity
posterior body cavity that houses the brain and spinal cord; also referred to the posterior body cavity
effector
two-dimensional, vertical plane that divides the body or organ into anterior and posterior portions
frontal lobe
study of the larger structures of the body, typically with the unaided eye; also referred to macroscopic anatomy
gross anatomy
process of increasing in size
growth
steady state of body systems that living organisms maintain
homeostasis
describes a position below or lower than another part of the body proper; near or toward the tail (in humans, the coccyx, or lowest part of the spinal column); also referred to as caudal
inferior
describes the side or direction toward the side of the body
lateral
medical imaging technique in which a device generates a magnetic field to obtain detailed sectional images of the internal structures of the body
magnetic resonance imaging (MRI)
describes the middle or direction toward the middle of the body
medial
sum of all of the body’s chemical reactions
metabolism
study of very small structures of the body using magnification
microscopic anatomy
homeostatic mechanism that tends to stabilize an upset in the body’s physiological condition by preventing an excessive response to a stimulus, typically as the stimulus is removed
negative feedback
range of values around the set point that do not cause a reaction by the control center
normal range
chemical obtained from foods and beverages that is critical to human survival
nutrient
functionally distinct structure composed of two or more types of tissues
organ
group of organs that work together to carry out a particular function
organ system
living being that has a cellular structure and that can independently perform all physiologic functions necessary for life
organism
sac that encloses the heart
pericardium
serous membrane that lines the abdominopelvic cavity and covers the organs found there
peritoneum
science that studies the chemistry, biochemistry, and physics of the body’s functions
physiology
imaginary two-dimensional surface that passes through the body
plane
serous membrane that lines the pleural cavity and covers the lungs
pleura
mechanism that intensifies a change in the body’s physiological condition in response to a stimulus
positive feedback
medical imaging technique in which radiopharmaceuticals are traced to reveal metabolic and physiological functions in tissues
positron emission tomography (PET)
describes the back or direction toward the back of the body; also referred to as dorsal
posterior
posterior body cavity that houses the brain and spinal cord; also referred to as dorsal cavity
posterior cavity
force exerted by a substance in contact with another substance
pressure
face down
prone
describes a position nearer to the point of attachment or the trunk of the body
proximal
study of the structures that contribute to specific body regions
regional anatomy
process by which worn-out cells are replaced
renewal
process by which worn-out cells are replaced
reproduction
ability of an organisms or a system to adjust to changes in conditions
responsiveness
two-dimensional, vertical plane that divides the body or organ into right and left sides
sagittal plane
in anatomy, a single flat surface of a three-dimensional structure that has been cut through
section
(also, receptor) reports a monitored physiological value to the control center
sensor
membrane that covers organs and reduces friction; also referred to as serous membrane
serosa
membrane that covers organs and reduces friction; also referred to as serosa
serous membrane
ideal value for a physiological parameter; the level or small range within which a physiological parameter such as blood pressure is stable and optimally healthful, that is, within its parameters of homeostasis
set point
division of the dorsal cavity that houses the spinal cord; also referred to as vertebral cavity
spinal cavity
describes a position nearer to the surface of the body
superficial
describes a position above or higher than another part of the body proper; also referred to as cranials
superior
face up
supine
study of the structures that contribute to specific body systems
systemic anatomy
division of the anterior (ventral) cavity that houses the heart, lungs, esophagus, and trachea
thoracic cavity
group of similar or closely related cells that act together to perform a specific function
tissue
two-dimensional, horizontal plane that divides the body or organ into superior and inferior portions
transverse plane
application of ultrasonic waves to visualize subcutaneous body structures such as tendons and organs
ultrasonography
describes the front or direction toward the front of the body; also referred to as anterior
ventral
larger body cavity located anterior to the posterior (dorsal) body cavity; includes the serous membrane-lined pleural cavities for the lungs, pericardial cavity for the heart, and peritoneal cavity for the abdominal and pelvic organs; also referred to as anterior body cavity
ventral cavity
form of high energy electromagnetic radiation with a short wavelength capable of penetrating solids and ionizing gases; used in medicine as a diagnostic aid to visualize body structures such as bones
X-ray
compound that releases hydrogen ions (H+) in solution
acid
amount of energy greater than the energy contained in the reactants, which must be overcome for a reaction to proceed
activation energy
nucleotide containing ribose and an adenine base that is essential in energy transfer
adenosine triphosphate (ATP)
building block of proteins; characterized by an amino and carboxyl functional groups and a variable side-chain
amino acid
atom with a negative charge
anion
smallest unit of an element that retains the unique properties of that element
atom
number of protons in the nucleus of an atom
atomic number
compound that accepts hydrogen ions (H+) in solution
base
electrical force linking atoms
bond
solution containing a weak acid or a weak base that opposes wide fluctuations in the pH of body fluids
buffer
class of organic compounds built from sugars, molecules containing carbon, hydrogen, and oxygen in a 1-2-1 ratio
carbohydrate
substance that increases the rate of a chemical reaction without itself being changed in the process
catalyst
atom with a positive charge
cation
form of energy that is absorbed as chemical bonds form, stored as they are maintained, and released as they are broken
chemical energy
liquid mixture in which the solute particles consist of clumps of molecules large enough to scatter light
colloid
substance composed of two or more different elements joined by chemical bonds
compound
number of particles within a given space
concentration
chemical bond in which two atoms share electrons, thereby completing their valence shells
covalent bond
type of catabolic reaction in which one or more bonds within a larger molecule are broken, resulting in the release of smaller molecules or atoms
decomposition reaction
change in the structure of a molecule through physical or chemical means
denaturation
deoxyribose-containing nucleotide that stores genetic information
deoxyribonucleic acid (DNA)
pair of carbohydrate monomers bonded by dehydration synthesis via a glycosidic bond
disaccharide
covalent bond formed within a polypeptide between sulfide groups of sulfur-containing amino acids, for example, cysteine
disulfide bond
subatomic particle having a negative charge and nearly no mass; found orbiting the atom’s nucleus
electron
area of space a given distance from an atom’s nucleus in which electrons are grouped
electron shell
substance that cannot be created or broken down by ordinary chemical means
element
protein or RNA that catalyzes chemical reactions
enzyme
type of chemical reaction in which bonds are both formed and broken, resulting in the transfer of components
exchange reaction
group of atoms linked by strong covalent bonds that tends to behave as a distinct unit in chemical reactions with other atoms
functional group
dipole-dipole bond in which a hydrogen atom covalently bonded to an electronegative atom is weakly attracted to a second electronegative atom
hydrogen bond
substance that does not contain both carbon and hydrogen
inorganic compound
atom with an overall positive or negative charge
ion
attraction between an anion and a cation
ionic bond
one of the variations of an element in which the number of neutrons differ from each other
isotope
energy that matter possesses because of its motion
kinetic energy
class of nonpolar organic compounds built from hydrocarbons and distinguished by the fact that they are not soluble in water
lipid
large molecule formed by covalent bonding
macromolecule
sum of the number of protons and neutrons in the nucleus of an atom
mass number
physical substance; that which occupies space and has mass
matter
two or more atoms covalently bonded together
molecule
monomer of carbohydrate; also known as a simple sugar
monosaccharide
heavy subatomic particle having no electrical charge and found in the atom’s nucleus
neutron
class of organic compounds composed of one or more phosphate groups, a pentose sugar, and a base
nucleotide
substance that contains both carbon and hydrogen
organic compound
covalent bond formed by dehydration synthesis between two amino acids
peptide bond
arrangement of the elements in a table according to their atomic number; elements having similar properties because of their electron arrangements compose columns in the table, while elements having the same number of valence shells compose rows in the table
periodic table of the elements
negative logarithm of the hydrogen ion (H<sup>+</sup>) concentration of a solution
pH
a lipid compound in which a phosphate group is combined with a diglyceride
phospholipid
addition of one or more phosphate groups to an organic compound
phosphorylation
molecule with regions that have opposite charges resulting from uneven numbers of electrons in the nuclei of the atoms participating in the covalent bond
polar molecule
compound consisting of more than two carbohydrate monomers bonded by dehydration synthesis via glycosidic bonds
polysaccharide
stored energy matter possesses because of the positioning or structure of its components
potential energy
one or more substances produced by a chemical reaction
product
lipid compound derived from fatty acid chains and important in regulating several body processes
prostaglandin
class of organic compounds that are composed of many amino acids linked together by peptide bonds
protein
heavy subatomic particle having a positive charge and found in the atom’s nucleus
proton
nitrogen-containing base with a double ring structure; adenine and guanine
purine
nitrogen-containing base with a single ring structure; cytosine, thiamine, and uracil
pyrimidine
unstable, heavy isotope that gives off subatomic particles, or electromagnetic energy, as it decays; also called radioisotopes
radioactive isotope
one or more substances that enter into the reaction
reactant
ribose-containing nucleotide that helps manifest the genetic code as protein
ribonucleic acid (RNA)
homogeneous liquid mixture in which a solute is dissolved into molecules within a solvent
solution
(also, sterol) lipid compound composed of four hydrocarbon rings bonded to a variety of other atoms and molecules
steroid
reactant in an enzymatic reaction
substrate
liquid mixture in which particles distributed in the liquid settle out over time
suspension
type of anabolic reaction in which two or more atoms or molecules bond, resulting in the formation of a larger molecule
synthesis reaction
lipid compound composed of a glycerol molecule bonded with three fatty acid chains
triglyceride
outermost electron shell of an atom
valence shell
form of transport across the cell membrane that requires input of cellular energy
active transport
describes a molecule that exhibits a difference in polarity between its two ends, resulting in a difference in water solubility
amphipathic
third stage of mitosis (and meiosis), during which sister chromatids separate into two new nuclear regions of a dividing cell
anaphase
consecutive sequence of three nucleotides on a tRNA molecule that is complementary to a specific codon on an mRNA molecule
anticodon
breakdown of cells by their own enzymatic action
autolysis
lysosomal breakdown of a cell’s own components
autophagy
life cycle of a single cell, from its birth until its division into two new daughter cells
cell cycle
membrane surrounding all animal cells, composed of a lipid bilayer interspersed with various molecules; also known as plasma membrane
cell membrane
small, self-replicating organelle that provides the origin for microtubule growth and moves DNA during cell division
centriole
region of attachment for two sister chromatids
centromere
cellular structure that organizes microtubules during cell division
centrosome
membrane-spanning protein that has an inner pore which allows the passage of one or more substances
channel protein
progress point in the cell cycle during which certain conditions must be met in order for the cell to proceed to a subsequence phase
checkpoint
substance consisting of DNA and associated proteins
chromatin
condensed version of chromatin
chromosome
small appendage on certain cells formed by microtubules and modified for movement of materials across the cellular surface
cilia
contractile ring that forms around a cell during cytokinesis that pinches the cell into two halves
cleavage furrow
consecutive sequence of three nucleotides on an mRNA molecule that corresponds to a specific amino acid
codon
difference in the concentration of a substance between two regions
concentration gradient
one of a group of proteins that function in the progression of the cell cycle
cyclin
one of a group of enzymes associated with cyclins that help them perform their functions
cyclin-dependent kinase (CDK)
final stage in cell division, where the cytoplasm divides to form two separate daughter cells
cytokinesis
internal material between the cell membrane and nucleus of a cell, mainly consisting of a water-based fluid called cytosol, within which are all the other organelles and cellular solute and suspended materials
cytoplasm
“skeleton” of a cell; formed by rod-like proteins that support the cell’s shape and provide, among other functions, locomotive abilities
cytoskeleton
clear, semi-fluid medium of the cytoplasm, made up mostly of water
cytosol
movement of a substance from an area of higher concentration to one of lower concentration
diffusion
condition marked by the presence of a double complement of genetic material (two sets of chromosomes, one set inherited from each of two parents)
diploid
enzyme that functions in adding new nucleotides to a growing strand of DNA during DNA replication
DNA polymerase
process of duplicating a molecule of DNA
DNA replication
difference in the electrical charge (potential) between two regions
electrical gradient
import of material into the cell by formation of a membrane-bound vesicle
endocytosis
cellular organelle that consists of interconnected membrane-bound tubules, which may or may not be associated with ribosomes (rough type or smooth type, respectively)
endoplasmic reticulum (ER)
export of a substance out of a cell by formation of a membrane-bound vesicle
exocytosis
one of the coding regions of an mRNA molecule that remain after splicing
exon
fluid exterior to cells; includes the interstitial fluid, blood plasma, and fluid found in other reservoirs in the body
extracellular fluid (ECF)
diffusion of a substance with the aid of a membrane protein
facilitated diffusion
appendage on certain cells formed by microtubules and modified for movement
flagellum
phase of the cell cycle, usually entered from the G<sub>1</sub> phase; characterized by long or permanent periods where the cell does not move forward into the DNA synthesis phase
G0 phase
first phase of the cell cycle, after a new cell is born
G1 phase
third phase of the cell cycle, after the DNA synthesis phase
G2 phase
functional length of DNA that provides the genetic information necessary to build a protein
gene
active interpretation of the information coded in a gene to produce a functional gene product
gene expression
entire complement of an organism’s DNA; found within virtually every cell
genome
coating of sugar molecules that surrounds the cell membrane
glycocalyx
protein that has one or more carbohydrates attached
glycoprotein
cellular organelle formed by a series of flattened, membrane-bound sacs that functions in protein modification, tagging, packaging, and transport
Golgi apparatus
enzyme that functions to separate the two DNA strands of a double helix during DNA replication
helicase
family of proteins that associate with DNA in the nucleus to form chromatin
histone
describes two copies of the same chromosome (not identical), one inherited from each parent
homologous
describes a substance or structure attracted to water
hydrophilic
describes a substance or structure repelled by water
hydrophobic
describes a solution concentration that is higher than a reference concentration
hypertonic
describes a solution concentration that is lower than a reference concentration
hypotonic
membrane-associated protein that spans the entire width of the lipid bilayer
integral protein
type of cytoskeletal filament made of keratin, characterized by an intermediate thickness, and playing a role in resisting cellular tension
intermediate filament
entire life cycle of a cell, excluding mitosis
interphase
fluid in the small spaces between cells not contained within blood vessels
interstitial fluid (IF)
fluid in the cytosol of cells
intracellular fluid (ICF)
non-coding regions of a pre-mRNA transcript that may be removed during splicing
intron
describes a solution concentration that is the same as a reference concentration
isotonic
region of a centromere where microtubules attach to a pair of sister chromatids
kinetochore
molecule that binds with specificity to a specific receptor molecule
ligand
membrane-bound cellular organelle originating from the Golgi apparatus and containing digestive enzymes
lysosome
nucleotide molecule that serves as an intermediate in the genetic code between DNA and protein
messenger RNA (mRNA)
second stage of mitosis (and meiosis), characterized by the linear alignment of sister chromatids in the center of the cell
metaphase
linear alignment of sister chromatids in the center of the cell, which takes place during metaphase
metaphase plate
the thinnest of the cytoskeletal filaments; composed of actin subunits that function in muscle contraction and cellular structural support
microfilament
the thickest of the cytoskeletal filaments, composed of tubulin subunits that function in cellular movement and structural support
microtubule
one of the cellular organelles bound by a double lipid bilayer that function primarily in the production of cellular energy (ATP)
mitochondrion
division of genetic material, during which the cell nucleus breaks down and two new, fully functional, nuclei are formed
mitosis
phase of the cell cycle in which a cell undergoes mitosis
mitotic phase
network of microtubules, originating from centrioles, that arranges and pulls apart chromosomes during mitosis
mitotic spindle
describes the condition of being able to differentiate into different types of cells within a given cell lineage or small number of lineages, such as a red blood cell or white blood cell
multipotent
change in the nucleotide sequence in a gene within a cell’s DNA
mutation
membrane that surrounds the nucleus; consisting of a double lipid-bilayer
nuclear envelope
one of the small, protein-lined openings found scattered throughout the nuclear envelope
nuclear pore
`small region of the nucleus that functions in ribosome synthesis
nucleolus
unit of chromatin consisting of a DNA strand wrapped around histone proteins
nucleosome
cell’s central organelle; contains the cell’s DNA
nucleus
`describes the condition of being more specialized than multipotency; the condition of being able to differentiate into one of a few possible cell types
oligopotent
any of several different types of membrane-enclosed specialized structures in the cell that perform specific functions for the cell
organelle
diffusion of water molecules down their concentration gradient across a selectively permeable membrane
osmosis
form of transport across the cell membrane that does not require input of cellular energy
passive transport
membrane-associated protein that does not span the width of the lipid bilayer, but is attached peripherally to integral proteins, membrane lipids, or other components of the membrane
peripheral protein
membrane-bound organelle that contains enzymes primarily responsible for detoxifying harmful substances
peroxisome
endocytosis of large particles
phagocytosis
endocytosis of fluid
pinocytosis
describes the condition of being able to differentiate into a large variety of cell types
pluripotent
chain of amino acids linked by peptide bonds
polypeptide
simultaneous translation of a single mRNA transcript by multiple ribosomes
polyribosome
region of DNA that signals transcription to begin at that site within the gene
promoter
first stage of mitosis (and meiosis), characterized by breakdown of the nuclear envelope and condensing of the chromatin to form chromosomes
prophase
full complement of proteins produced by a cell (determined by the cell’s specific gene expression)
proteome
a group of extremely reactive peroxides and oxygen-containing radicals that may contribute to cellular damage
reactive oxygen species (ROS)
protein molecule that contains a binding site for another specific molecule (called a ligand)
receptor
endocytosis of ligands attached to membrane-bound receptors
receptor-mediated endocytosis
RNA that makes up the subunits of a ribosome
ribosomal RNA (rRNA)
cellular organelle that functions in protein synthesis
ribosome
enzyme that unwinds DNA and then adds new nucleotides to a growing strand of RNA for the transcription phase of protein synthesis
RNA polymerase
stage of the cell cycle during which DNA replication occurs
S phase
feature of any barrier that allows certain substances to cross but excludes others
selective permeability
one of a pair of identical chromosomes, formed during DNA replication
sister chromatid
(also, Na<sup>+</sup>/K<sup>+</sup> ATP-ase) membrane-embedded protein pump that uses ATP to move Na<sup>+</sup> out of a cell and K<sup>+</sup> into the cell
sodium-potassium pump
all cells of the body excluding gamete cells
somatic cell
complex of enzymes that serves to splice out the introns of a pre-mRNA transcript
spliceosome
the process of modifying a pre-mRNA transcript by removing certain, typically non-coding, regions
splicing
cell that is oligo-, multi-, or pleuripotent that has the ability to produce additional stem cells rather than becoming further specialized
stem cell
final stage of mitosis (and meiosis), preceding cytokinesis, characterized by the formation of two new daughter nuclei
telophase
embryonic cells that have the ability to differentiate into any type of cell and organ in the body
totipotent
process of producing an mRNA molecule that is complementary to a particular gene of DNA
transcription
one of the proteins that regulate the transcription of genes
transcription factor
molecules of RNA that serve to bring amino acids to a growing polypeptide strand and properly place them into the sequence
transfer RNA (tRNA)
process of producing a protein from the nucleotide sequence code of an mRNA transcript
translation
consecutive sequence of three nucleotides on a DNA molecule that, when transcribed into an mRNA codon, corresponds to a particular amino acid
triplet
describes the condition of being committed to a single specialized cell type
unipotent
membrane-bound structure that contains materials within or outside of the cell
vesicle