What causes Increased intercranial pressure?
_
Traumatic Brain injuries from concussion
ruptured cerebral aneurysm
stroke
obstructions in the circulation of CSF
infectious disorders of the nervous system such as a meningitis and encephalitis
Client present w/
Drowsiness, Difficult to awaken
restlessness
confusion
irritability
Glasgow Coma Scale>13
Personality changes
sluggish or unequal pupil response
weakness in arms or legs
slow or slurred speech
Dull headache, especially upon awakening
vomiting without nausea
Early signs of Increased Intracranial Pressure
What are some Late signs of Increased Intracranial Pressure
Unresponsive
Glasgow Coma Scale<12
Decreased response to painful stimuli
Decorticated or Decerebrated posturing
Increased weakness or Hemiparesis
Dilated Pupil(s)
Seizures
Cushing triad: Bradycardia, elevated systolic blood pressure w/wide pressure, irregular breathing
loss of gag or corneal reflexes
period of apnea
What is the First sign of ICP before any other?
Decreased Level of Consciousness (LOC)
Can be accompany by lethargic, stupors, semi-comatose, to comatose.
Confusion restlessness and periodic disorientation accompany decreased LOC
What is Papilledema?
Swelling of the optic nerve
Client present w/
Pulse rate that increase initially but then decrease
Systolic BP rise w/a widening pulse pressuse
Cushing Triad
What is done to DX's underlying causes of ICP?
Skull radiography
CT, MRI
Lumbar Puncture
Cerebral angiography
Medical TX's for ICP
Decreasing ICP by relieving the cause
Maintain BP, Prevent Hypoxia
Mechanical Ventilator
Client head maintain at midline of 30
True or False
Shivering and seizures can cause increase ICP?
True
What can be given when ICP can't be reduce?
Sedation w/ Barbiturates and propofol (helps with seizure)
Nursing MNGT's for ICP client?
Gather history of leading up to injury for client of witness, or technician,
Medical History
LOC/VS
assist with head -to toe exam
neurologic assessment q 30-60 min
obtain current and daily WT, I's and O's,
monitor electrolytes and ABG's
evaluate bowel sound and elimination
note evidence of seizures
Nursing care plan 37-1 610-612
Nursing care plan 37-1 610-612
What is meningitis?
Inflammation of the meninges caused by various infections microorganism
Bacteria, Viruses, fungi, or Parasites
What are the pathogens that causes Meninges?
Bacteria (meningococci and streptococci)
Viruses (HSV, Mumps, Enteroviruses)
What space so the microorganism travel through?
Subarachnoid
Client present w/
Headache
Fever
nuchal rigidity (stiff neck not able to place chin on chest)
N/V
Photophobia (aversion or sensitivity to light)
Restlessness
irritability
seizure
small to large petechiae( rug burn appearance)
Maculopapular rash (viral)
Meningitis
Severe irritation of Meninges causes hyperextension of head and arching of the back?
Opisthotonos
- Inability to extend the leg when the thigh is flexed on the abdomen
Positive Kernig sign
Positive Brudzinski Sign
flexion of the neck produces flexion of the knee and hips
- What DX's is use for Meningitis?
Lumbar Puncture (on CSF) Cloudy (Bacterial)
Elevated CSF, Decrease Glucose concentration, Elevated Protein level
WBC and RBC are elevated
C&S to determine Bacterial causative
Viral C&S negative
CT, Blood culture, CBC rule out other poss. disorders
What medical management are done to treat Meningitis?
Hand Hygiene
Local Health department is notified of all cases
IV fluids
antimicrobial therapy (bacterial)
Penicillin, Cephalosporin, Rifampin (turn secretion orange) Ciprofloxacin, azithromycin or a IM dose of cefriaxone
What vaccine is recc for all college and universities ?
Meningococcal meningitis
Haemophilus influenzae type b reduce the acquistion of bacterial meningitis
What is encephalitis
Inflammatory process affecting the CNS
What is the most common cause of Encephalitis?
Vector-borne viral infections
(St. Louis, western equine, eastern equine, West Nile)
Transmit by Ticks and Mosquitoes
Client present w/
Sudden fever
severe headache
stiff neck
vomiting
drowsiness
Insect bite on physical exam
Worsen infection
tremors, seizures, Spastic or Flaccid paralysis, Irritability and Muscle Weakness, Lethargy, delirium or coma, incontinence and visual disturbances involuntary eye movement, double or blurred vision
Viral encephalitis
What diagnostic procedure is done to Dx's encephalitis
Lumbar puncture CSF elevated Fluid is Clear
West Nile blood or CSF show rise in IGM antibodies
EEG Slow waveforms
MRI, CT to rule out other etiologies
What medical Management is use to treat encephalitis?
antipyretics
anticonvulsants
anti-inflammatory drugs and analgesics
what are nursing intervention for encephalitis?
Monitor VS and LOC frequently
Consult PCP if Indwelling catheter for urinary incontinence or urinary retention
Measure I's and O's (sign Fluid volume deficit) electrolyte imbalance
assess Bowel elimination to deter if stool softener or enema is needed
- Pay attention to surveillance reports concerning the incidence of birds infected with West Nile virus or St. Louis virus in your community.
- Avoid being outdoors during peak mosquito biting times, such as early evening.
- Wear clothing that covers as much skin as possible when outdoors.
- Apply insect repellant containing permethrin or DEET to clothing and exposed skin.
- Repair or replace windows and door screens.
- Place netting around strollers and infant carriers.
- Empty outdoor items frequently that may hold standing water.
- Transport discarded tires to a location for waste management.
- Clear gutters of debris that may obstruct the drainage of rainwater
Measures to Control Exposure to Mosquitoes
What is Guillain-Barré syndrome?
acute postinfectious polyneuropathy, polyradiculoneuritis) affects the peripheral nerves and the spinal nerve roots.
What is the cause of GBS Guillain–Barré syndrome?
exact cause of the disorder is unknown,
Is believed to be an autoimmune reaction
History of recent surgery
recent vaccination for viral disease(FLU)
What are the different types of Guillaun-Barre syndrome GBS?
- Acute inflammatory demyelinating polyradiculoneuropathy is most common (muscle weakness lower extremities and moves upward)
- (Viral) Miller fisher syndrome begin 1-4wks after infection begin with weakness in eye muscle and progressed down
Client present w/
Weakness, numbness and tingling in the arm and leg(painful the 1st symptoms)
Paralysis, weaken Muscle
If Cranial nerve involve (Chewing talking and swallowing difficult)
Guillaun-Barre syndrome
What procedures are us to Dx's Guillaun-Barre syndrome
Lumbar puncture reveal Elevated CSF, Protein level and Pressure
Electrophysiological test marked slow conduction of nerve impulses
What are some Medical Management for Guillaun-Barre syndrome
- Plasmapheresis (remove plasma from the blood and reinfusion of the cellular components w/saline shorten the course of DX.)
- Administer IV immune globulin May enhance improvement
- Supportive treatment( gabapentin, amitriptyline or opioid to relieve discomfort
- Endotracheal intubation and mechanical ventilation
- IV fluids, gastric tub feeding or Parenteral Nutrition (PTN)
Nursing intervention for client with Guillaun-Barre syndrome
observe the client for respiratory distress
spirometer to evaluate the clients ventilation capacity
assess for pneumonia
check VS and lung sound frequently
provide meticulous skin care position change q2hours
help client perform active and passive exercises to prevent muscle atrophy
What is a Brain abscess?
Collection of purulent material in the brain
What causes a brain abscess?
Infection in the middle ear, sinuses or teeth or infection or organs
After intracranial surgery or head trauma
secondary to such disorders Bacterial endocarditis, bacteremia, Pulmonary or abdominal infection
The client is present with/
Increased ICP, Fever, headaches,
neurologic changes ( paralysis seizures, muscle weakness, lethargy)
Brain Abscess
What is done to DX's Brain Abscess?
Elevated WBC
CSF by lumbar confirms DX( risk for herniation of brain stem)
CT, MRI and Skull radiography are safer techniques for diagnosing and locating the abscess
What medical management for Brain Abscess?
Antimicrobial therapy once dx confirmed.
Craniotomy done to drain abscess
Cerebral edema and seizure treated with drug therapy
Control fever, mechanical ventilation, IV fluids and nutritional support
Nursing management for brain abscess
Assess frequently for altered LOC
change in sensory and motor functions
Sign of ICP monitors VS frequently
measures fluids I's and O's for overhydration that can leaded to Cerebral edema
What is Multiple Sclerosis?
Chronic progressive dx of the Peripheral nerves
What cause a client to have MS?
Trigger by a defective genes
Why is MS characterized by demyelinating dx
Cause permanent degeneration and destruction of myelin
Client present w/
Pressure ulcers, cachexia, deformities, and contractures develop
Pneumonia by limited activity
Shallow breathing and general Debility cause death
1st is fatigue and strain
blurred vision, diplopia( double vision)
Nystagmus weakness, clumsiness and numbness and weakness and tingling of an arm or leg .
intention tremor and slurred, hesitant speech, mood swings are commonParaplegis Bowel or bladder incontinence
Multiple Sclerosis
What Dx's are done to confirm multiple Sclerosis?
Lumbar puncture for CSF reveal increased WBC count
Electrophoresis of CSF reveal abnormal immunoglobulin G bsnd
CT MRI my or may not be discolsed lesion in the brains white matter
True or false
There is a cure for MS?
False there is no cure for MS, nor a single treatment that relieves all symptoms
What are medical management for MS?
Keep client functional as long as possible
Current research for promoting nerve regeneration
Medication use 1st dx's modifying drug Interferon beta-1a(avonex) Interferon beta-1b(betaseron), fingolimod(Gilenya)
Newer Drugs Immunosuppressive Alemtuzumab, Natalizunba, teriflunomide inhibit neurodegeneration
baclofen and dantrolene for muscle spasticity and rigidity
antibiotic for infection
tranquilizer alleviate mood swings
Oxybutynin and Botulinum toxin manage urinary incontienence
bethanechol use to relieve urinary retention
anti-inflammatory action of corticosteroids relieve symptoms and hastens remissions
What are some nursing management for clients with MS?
Assess the client current physical and emotional status new developments or changes to previously assess
identifies the client visual problem emphasize that these may diminish when a remission occurs
listen to clients speech (rec. language board or assistive devices)
assess weight regularly blenderization of food in swallowing is impaired
Manage constipation with high fiber food and fluids
provide instruction concerning drug therapy
What is Myasthenia Gravis?
Neuromuscular disorder characterized by severe weakness of on or more groups of skeletal muscles
Most common in women
What are some causes of Myasthenia Gravis?
Cause is unknow
believed to be autoimmune in nature
The client is present w/ is what?
Muscle weakness
Ptosis(drooping of eyelids) most common
difficulty chewing, swallowing, diplopia, voice weakness,
Masklike facial expression, Weakness of the extremities
Respiratory system is affected
Myasthenia Gravis
The client present w/ is what?
Increase muscle weakness
respiratory distress
decreased tidal volume
difficulty talking, swallowing and chewing
Myasthenic Crisis
How do you Dx's Myasthenia Gravis?
IV administration of edrophonium (tensilon) relieve muscle weakness in a few seconds then dissipate in about 5 min
elevated acetylcholine receptor antibody titer
Chest radiography show enlargement of thymus(thymoma)
Electromyography measures the electrical potential of muscles
What are some medical and surgical management for client with Myasthenia Gravis?
Administer Anticholinesterase (Pyridostigmine bromide) mestinon, (neostigmine) prostigmin or (ambenonium Chloride) mytelase facilitate normal neurotransmission
surgical removal of thymus gland
for client who don't response to therapy Prednisone or other immunosuppressant (azathioprine) Imuran TID a week
Myasthenic Crisis w/severe respiratory distress requires intubation and mechanical ventilation
What are some nursing management for client with Myasthenia Gravis?
Provide periods of rest
support ventilation by elevating the head of the bed and suction secretion w/difficulty in swallowing
make effort to understand the client when speech is compromises
demonstrates patience and empathy
administer medication at exact times to maintain therapeutic blood level
observe for signs of drug overdose (abd cramps, clenched jaws, muscle rigidity)
What is Amyotrophic Lateral Sclerosis (Lou Gehrig disease)?
Progressive and fatal neurologic disorder
Common in men than women
What cause of Amyotrophic lateral sclerosis?
Cause is unknown
Client Present w/ is what ?
Progressive muscle weakness and wasting of arms, legs and truck
Muscle Fasciculations (twitching)
If brain stem is affected (speaking and swallowing becomes difficult)
Inappropriate laughing and crying
Respiratory failure and total Paralysis (Terminal stages)
Amyotrophic Lateral Sclerosis (Lou Gehring Disease)
How is ALS DX's ?
Difficult to diagnose in the early stage No specific diagnostic test
Electromyography validated weakness in the affected muscles
What are some medical management for ALS?
no specific treatment, death occurs several years after Dx
encourage remain active as long as possible
Mechanical ventilation when ALS affect muscles of respiration
treated with riluzole slow progression and delay need for Trachestomy
What are some nursing management for client with Amyotrophic lateral Sclerosis?
Comprehensive assessment and plan of care on client basis problems
Provide assist with walking, bathing, shaving and dressing
teach family required skills ( suctioning, how to administer feeding tubes and catheter care
Client and family teaching for client with ALS
Medication schedule, adverse effects of medications
Dietary and
feeding suggestions
Agencies that can help with or give home
care
Sources of financial assistance
Exercises to prevent
muscle atrophy
Positioning and good skin care
Techniques for
preventing skin breakdown
Nursing process for client with chronic neuromuscular disorder 621-622
Nursing process for client with chronic neuromuscular disorder 621-622
What is Trigeminal Neuralgia (Tic Douloureux)?
Painful condition that involves the 5th cranial nerve
3 major branches ( Mandibular maxillary and ophthalmic)
for Chewing facial movement and sensation
What is the cause of Trigeminal Neuralgia Nerve pain?
Unknown
Suggested it could be related to compression of the trigeminal nerve root
Client present w/ is what?
sudden pain, severe and burning
Pain ends as quick as it begins
repeat many time a day
face twitches and eye tear during spasm
Trigeminal Neuralgia
What is done to DX's Trigeminal Neuralgia?
Skull radiography, MRI or CT are preformed to rule out other pathologies
DX's is base on symptoms
What medical treatment for Trigeminal Neuralgia?
Supportive and symptomatic
opioids
Anticonvulsants (phenytoin) Dilantin and (Carbamazepine) Tegretol reduce pain
Check toxicity level
Dentist referral correction of dental Malocclusion (relieve some cases)
What are surgical management for trigeminal Neuralgia?
Surgical division of sensory root of trigeminal nerve provides permanent relief
Nursing process for client with Trigeminal Neuralgia 623-624
Nursing process for client with Trigeminal Neuralgia 623-624
Client and Family Teaching for Trigeminal Neuralgia
Inspect the mouth daily for breaks in the mucous membrane.
Take
small sips or bites of food and concentrate on chewing and swallowing
if surgery has been performed.
Chew on the opposite
side.
Avoid eating hot foods.
Use mouth rinses after
eating.
Keep regular dental appointments because the warning pain
of a cavity, abscess, or other dental problem may be mistaken for neuralgia.
What is Bell Palsy?
involves the 7 cranial nerve that originates in the pons
What causes Bell Palsy?
Unknown, But viral link it suspected
Client is present w/is what?
Symptoms develop in few hour to over 1-2 days
Facial pain, pain behind the ear numbness, diminished blink reflex
Ptosis of eyelid ,Tearing on the effected side
Speaking and chewing become difficult
Bell Palsy
What is done to DX's Bell Palsy?
No specific diagnostic tests
Based on symptoms and visual examination to the face.
Electromyography (EMG) Determine if any residual nerve and muscle activity
MRI or CT scan rule out other etiologies
What medical treatment is use for Clients w/ Bell palsy?
Short-term high dose Corticosteroid therapy w/ prednisone Reduce nerve inflammation and edema
Antiviral acyclovir, Famciclovir or valacyclovir inhibit viral replication and shorten symptoms
B complex vitamin
Facial reanimation Improve facial movement and appearance
Nursing process for client with Bell palsy 625
Chew on unaffected side, protect eye with eye patch
Nursing process for client with Bell palsy 625
Chew on unaffected side, protect eye with eye patch
What is the cause of Parkinson Disease?
Deficiency of Dopamine
The imbalance between dopamine and acetylcholine result in movement disorder
Client present w/ is what?
Stiffness, pill-rolling tremor fine tremor, hand tremor
Bardykinesia Slowness preforming spontaneous movement
Masklike expression, stooped posture Hypophonia (low volume of speech) difficulty swallowing saliva and food, Weight loss occurs
Shuffling gait Arms are rigid While Walking
Foward lean
Parkinson Disease
Nutrition notes for client with Parkinson Disease?
High fiber crushed bran added to hot cereal and fiber-fortified supplement
prevent constipation w/fluids prunes and prune juice stimulate peristalsis
Taking levodopa should avoid high intake of protein decreasses it effectiveness
High protein diet for client with weight loss
Client present w/
affect the jaw tongue and larynx, speech is slurred and chewing and swallowing become difficult
Rigidity can lead to contractures
Salivation increases accompanied by drooling
Cogwheel rigidity muscles ( stop and go motion)
Late stage Parkinson Diseases
What diagnosis is use for Parkinson Disease?
Typical symptoms and neurologic examination
Medical treatment for Parkinson Disease?
Aim to prolong independence
Drug Selegiline( Eldepryl) Levodopa (larodopa) levodopa-carbidopa (sinemet) Amantadine (symmetrel) Bromocriptine (parlodel) Apomorphinr (apokyn) Benztropine (cogentin)
Rehabilitation measures physical therapy occupational therapy client family education and counseling
Surgical management for clients with Parkinson Disease
Deep Brain Stimulation implantation of the neurostimulation Pacemaker for the brain
Gene therapy
Transplant of fetal dopamine neurons
Nursing Management for client with Parkinson Disease are
Managing Client drug Therapy
Levodopa associated with periods of break through or end of dose wearing off
apomorphine help relieving the above
Help with walking OT and PT
small meals, difficult swallowing
37-2 and 37-1 some meds look at safety B6
What is Huntington disease?
Hereditary disorder of the CNS
The client present with
mental apathy and emotional disturbance
Choreiform movements, grimacing difficulty chewing and swallowing, speech difficult, intellectual decline and loss of bowel and bladder control
Severe depression
Huntington disease
How is Huntington disease diagnostic?
Base on the symptoms and family history
PET scan shows CNS changes
Genetic testing can predict which member will develop the disease
What are some medical management for Huntington's
Treatment is supportive , No cure
Tranquilizers and antiparkinson drug relieve choreiform, movements in some clients
No drug available TO HALT THE MENTAL DETERIORATION
Genetic counseling before a pregnancy is advised
nursing management for client with Huntington's disease
Help with ADL's were the client can do.
encourage client to lead a normal life,
Demonstrates how to use both hands to hold drink, use a straw to drink and wear slip on shoes
Increase risk for acquired infections especially if the client is catheterized
What is a seizure?
Safety for client on meds 37-2 and 37-3
brief episode abnormal electrical activity in the brain
Convulsion symptom of a seizure (spasmodic) contractions of muscles
Epilepsy chronic recurrent pattent of seizure
What causes seizure in a client?
Idiopathic
High fever
electrolyte imbalances
uremia
Hypoglycemia
hypoxia
brain tumor
drug abuse and Alcohol withdrawal
Client present with/
Motor symptoms
No LOC
seizure last less than 1 minute
uncontrolled jerking of body part (finger, mouth, hand or foot)
Sensory Symptoms
Hallucinatory Sight, sounds and odors, mumbling, and use of nonsense word
Partial Seizures
True or False Generalized seizure involves the entire brain?
True
Client present after a seizure that last for several second to several minutes and lose of consciousness is ?
Generalized Seizure
What are Absence seizure
Brief loss of Consciousness or Cognition during which physical activity ceases
Client present in the with
Stares blankly
the eyelids flutter
the lips move and slight movement of the head and leg occurs
lasting on for a few seconds
Absence Seizures
Misidentified as a learning disability
Client present with
brief activity of sudden excessive jerking of the arms leg or entire body and fall to the ground
Myoclonic seizures
Tonic-clonic seizure are also called
Grand Mal seizures
What is Preictal Phase?
happen before a seizure that could be vague emotional changes, depression, anxiety and nervousness.
Lasting for minutes of hours before a seizure
What is a Aura?
Sensation that occurs immediately before the seizure.
Sensory( Hallucinatory or odor or sound) or weakness or numbness
always the same
When and what is the epileptics cry?
Epileptics Cry after the aura and it is the spasm of the respiratory muscles of the throat and glottis
after Cry the client will have LOC (tonic-Clonic phase)
Muscles contract rigidly in Clonic phase
Contraction and relaxation of muscle, jerking movement and thrashing of the arms and legs, skin cyanotic and breathing spasmodic
Saliva mixed with air (Frothing at the mouth
Jaws tight clenched, biting of the tongue and inner cheek my occur, urinary and fecal incontinence is common
Clonic phase last for 1 min or more
What is Postical phase?
Period following the seizure client has Headache, Fatigue, Deep, sleep Confusion, Muscle soreness
What is status epilepticus?
After a tonic-Clonic a client does not regain consciousness between seizure.
If not treated Death can occur
Can be brought in by anticonvulsant abrupt stopping. Must be withdrawn gradually
What is Atonic seizure and Akinetic ?
LOC briefly and falls to the ground, recovery rapid (atonic)
Similar client may or may not fall and recovery rapid
What is done to DX's a Atonic Seizure?
Neurologic exam
EEG performed
CT, MRI, Serology and serum Electrolyte levels Confirm DX and determining cause of seizure
If EEG required if 1st on normal if epilepsy is suspected
What are medical management for client with seizure disorders?
Client need to have a current and updated medical list
- Anticonvulsant drugs use Phenytoin, Phenobarbital, Cabamazepine, Ethosuximide, Valproic acid, Felbamate, Gabapention and Fosphenytoin injection
- To terminate Epilepticus IV lorazepam, Diazepam, Midazolam. Alterated drug are IV fosphenytoin valproic acid or levetiracetam
- If seizure continue for 40 mins or more Thiopental or propofol my be required
Drug Therapy 37-2 633-634
Drug Therapy 37-2 633-634
What are some surgical Management for clients with seizures?
Surgery only if client does not response to drug or the seizures are severe
Surgeon must consider if part of brain will cause neurologic dysfunction( paralysis) or loss of speech
What are nursing interventions for clients with seizures?
See nursing process for client p636
Medical history and if they have seizures and treatment regimen
identifies client who may be prone to seizure
Promote safety (suction, oral airway, and oxygen equipment at the bedside, padded siderails and head board bed lowest position
administered and reinforces drug compliance
event of seizure
position client on side loosen restrictive clothing
airway keep patient, suction and oxygen if need
inspected for injuries to tongue, teeth, and buccal cavity
If incontinent clean the client and change linen
Document situation that lead up to seizure duration of seizure and parts of body involved, VS, Oxygen
Anticonvulsants impair vitamin D metabolism
Leads to calcium imbalance, rickets or osteomalacia if supplemental vitamin D is not given
Childrens who seizures are not well control need
High Fat diet
What is a brain tumor?
Growth of abnormal cells within the cranium
What causes a brain tumor?
Congenital
Genetic factors
Viral infection
exposure to radiation
head trauma
immunosuppression
Client present with
Headache (most common in the Morning), vomiting, papilledema
Vomiting without Nausea or warning
seizure develop,
behavior and mood changes speech difficulty, paralysis and double vision
Brain tumor
What is done to diagnosis Brain tumor in a client?
CT scan, MRI, Brain scan, and Cerebral angiography show Tumor's size and location
What are medical management for client that has a brain tumor?
Brain tumor Treat by surgery, radiation therapy, Chemotherapy,
Metastatic tumors some are inoperable, radiation therapy and Chemotherapy the only treatment choices
if cant do surgery are keep comfortable and free from pain as possible
to destroy or slow down tumor growth (intra-arterial or intrathecal)
symptomatic drug includes Corticosteroids and osmotic diuretics reduces cerebral edema, analgesics, anticonvulsants and antibiotics
What are surgical interventions for clients with Brain tumors?
Craniotomy incision through skull
Craniectomy excision of part of the skull
What is a Gamma-Knife radiosurgery?
Noninvasive procedure for treating deep brain tumor or that conventional surgery can only partially remove
Laser procedure
Outpatient basis or 24 hour inpatient stay involves more than one procedure
Headaches, minor nausea after treatment , Temporary hair loss my occur if tumor is close to surface
What are some nursing interventions for client with brain tumor?
Medication regimen
Appointments for chemotherapy or radiation
therapy
Adverse effects of chemotherapy or radiation and
techniques for managing them
Nutritional support
Home care
considerations
Rehabilitation (exercises, physical
therapy)
Referrals to support services for physical, emotional,
and financial assistance