Pathophysiology: Final quiz 2 Flashcards

Dramatic hypotension sometimes accompanies type I hypersensitivity reactions, because

Which disorder is associated with a type III hypersensitivity mechanism of injury?

A child with a history of recent strep throat infection develops glomerulonephritis. This is most likely a type _____ hypersensitivity reaction.

RhoGAM (an Rh antibody) would be appropriate in an Rh-_____ woman with an _____ Rh-_____ antibody titer carrying an Rh-_____ fetus.

Which disorder is considered a primary immunodeficiency disease?

Patients with immunodeficiency disorders are usually first identified because they

Severe combined immunodeficiency (SCID) syndrome is an example of a(n)

Certain autoimmune diseases are associated with the presence of specific proteins on a person’s cells. These proteins are called ________ proteins.

The most common primary immune deficiency that affects only B cells is

Transfusion reactions involve RBC destruction caused by

The hypersensitivity reaction that does not involve antibody production is type

The principle Ig mediator of type I hypersensitivity reactions is

Myasthenia gravis is a type II hypersensitivity disorder that involves

A primary effector cell of the type I hypersensitivity response is

An important mediator of a type I hypersensitivity reaction is

The effects of histamine release include

Autoimmune diseases result from (Select all that apply.)

Secondary immune deficiency problems may be caused by (Select all that apply.)

Anaphylaxis may occur in certain hypersensitivity reactions, including type (Select all that apply.)

Seasonal allergic rhinitis is most involved in type ____ hypersensitivity reactions

The major cause of death from leukemic disease is

A 58-year-old woman is seen in the clinic for reports of severe back pain. Her chest X-ray demonstrates generalized bone demineralization and compression fracture. Blood studies demonstrate elevated calcium levels. The most likely diagnosis is

Renal insufficiency is a common complication of which disease?

The patient is a 12-year-old boy diagnosed with acute lymphoid leukemia (ALL). As part of treatment, the patient must undergo several weeks of chemotherapy. The most serious complication of chemotherapy is

While in the hospital for management of acute lymphoid leukemia (ALL), a patient develops severe thrombocytopenia. The most appropriate action for this condition is

The Philadelphia chromosome is a balanced chromosome translocation that forms a new gene called

Which form of leukemia demonstrates the presence of the Philadelphia chromosome?

In general, the best prognosis for long-term disease-free survival occurs with

Which type of leukemia primarily affects children?

Which group of clinical findings describes the typical presentation of ALL (acute lymphoid leukemia)?

What is the correct definition of complete remission (CR) of leukemia?

Burkitt lymphoma is most closely associated with

Autologous stem cell transplantation is a procedure in which

A diagnostic laboratory finding in myeloma is

A 5-year-old patient’s parents report loss of appetite and fatigue in their child. The parents also state that the child refuses to walk due to pain. The child’s most likely diagnosis is

The patient is a 12-year-old boy with acute lymphoblastic leukemia (ALL). Manifestations of the patient’s leukemia prior to treatment may include (Select all that apply.)

Which viruses have been implicated as cancer-causing agents? (Select all that apply.)

A patient is diagnosed with CML (chronic myeloid leukemia). The patient may experience which of these symptoms? (Select all that apply.)

The only known curative treatment for CML is _____ bone marrow transplantation from a suitable donor.

Two of the most serious oncology emergencies associated with non-Hodgkin lymphoma are obstruction of the superior vena cava and compression of the _________.

A normal bleeding time in association with normal platelet count, and increased prothrombin time (PT) and INR, is indicative of

The final step in clot formation is

Dysfunction of which organ would lead to clotting factor deficiency

The conversion of plasminogen to plasmin results in

Activation of the extrinsic pathway of coagulation is initiated by

The prothrombin time (PT) and INR (International Normalized Ratio) measure the integrity of

The activated partial thromboplastin time (aPTT) is a measure of the integrity of

A commonly ingested substance associated with prolongation of the bleeding time is

The megakaryocyte is a precursor to

A cause of thrombocytopenia includes

Widespread activation of the clotting cascade secondary to massive trauma is called

A 3-year-old boy who exhibits prolonged bleeding after minor trauma and a prolonged aPTT, but a normal platelet count, is likely to be diagnosed with

Treatment for hemophilia A includes

Disseminated intravascular coagulation may be treated with heparin therapy to

A deficiency of von Willebrand factor impairs

A patient presents to the physician’s office with pinpoint hemorrhages on the skin. The patient is most likely between the ages of _____ years

A patient is diagnosed with a tortuous blood vessel of the right hand that bleeds spontaneously. This patient presents with

A newborn has melena, bleeding from the umbilicus, and hematuria. The newborn most likely experiencing

What is involved in the release of plasminogen activators? Select all that applies

The ________ is responsible for the synthesis of coagulation factors, with the exception of part of factor VIII

Hemophilia B is also known as ________ disease

A male patient involved in a motor vehicle accident is brought to the emergency department with acute flank pain. What additional signs of bleeding may the patient exhibit? (Select all that apply.)

Which diseases may be associated with a bleeding problem? (Select all that apply.)